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    COMPOSITION OF EXTERNAL AGENT
    1.
    发明专利
    COMPOSITION OF EXTERNAL AGENT 失效

    公开(公告)号：JPH07233036A

    公开(公告)日：1995-09-05

    申请号：JP2171594

    申请日：1994-02-21

    Applicant: KAO CORP

    Inventor： HONDA YASUKI ,  SUGIMURA YORIO

    IPC: C12P21/00 ,  A61K8/00 ,  A61K8/64 ,  A61K8/72 ,  A61K8/97 ,  A61K36/48 ,  A61P17/00 ,  A61Q19/00 ,  C12R1/91 ,  A61K7/48 ,  A61K7/00

    Abstract: PURPOSE:To obtain a composition of a cosmetic, an external medicine, etc., composed of a specific glycoprotein and excellent in skin protecting effect, humectant effect, highly smoothening effect, etc. CONSTITUTION:This composition is composed of preferably 0.0001-10wt.% (especially 0.02-2wt.%) of a glycoprotein which contains 5097% (preferably 70-97%) of a sugar containing arabinose, galactose, rhamnose and uronic acid as main constituting sugars, which is produced by preferably culturing cells of a plant (especially Psophocarpus tetragonolobus) which belongs to the family Fabaceae. The glycoprotein is obtained by preparing explant consisting of a part of an aseptic seedling of a plant which belongs to the family Fabaceae, inducing a callus from the explant by adding a plant hormone and a sugar, e.g. saccharose to the medium for plant culture, further subjecting the callus to shaking culture after transferred to a liquid medium, concentrating the cultured medium after the callus is removed, obtaining precipitate by adding ethanol to the concentrated liquid and finally lyophilizing the precipitate.

    PRODUCTION OF AROMOLINE
    2.
    发明专利
    PRODUCTION OF AROMOLINE 失效

    公开(公告)号：JPH045238A

    公开(公告)日：1992-01-09

    申请号：JP10725390

    申请日：1990-04-23

    Applicant: KAO CORP

    Inventor： SUGIMOTO YUKIHIRO ,  SUGIMURA YORIO

    IPC: A61K36/18 ,  A61P9/08

    Abstract: PURPOSE:To obtain in large quantities at low cost aromoline having various physiological activities such as vasodilative activity and antiallergic activity by separating and collecting aromoline from the enlarged or lumpy roots of Sinomenium diversifolium. CONSTITUTION:The enlarged or lumpy roots of Sinomenium diversifolium are e.g. dried and ground and then extracted with an organic solvent (pref. a lower alcohol, esp. methanol). The solvent is then distilled off, and the residue is extracted with an acidic aqueous solution of pH

    VASODILATOR
    3.
    发明专利
    VASODILATOR 失效

    公开(公告)号：JPH02169519A

    公开(公告)日：1990-06-29

    申请号：JP32464988

    申请日：1988-12-22

    Applicant: KAO CORP

    Inventor： SUGIMOTO YUKIHIRO ,  KAMIYA TETSURO ,  SUGIMURA YORIO ,  HARA KENJI

    IPC: C07D491/18 ,  A61K31/47 ,  A61K36/00 ,  A61K36/18 ,  A61K36/29 ,  A61K36/71 ,  A61P9/08

    Abstract: PURPOSE:To obtain a vasodilator containing allomoline as an active ingredient, having strong vasodilation activity, vasodepressor activity, peripheral circulation activity, etc., and useful as a hypotensor, etc. CONSTITUTION:The aimed vasodilator containing allomoline expressed by the formula as an active ingredient. Although a material isolated from the Menispermaceae plant can be used, since allomoline is contained in Menispermaceae plant, etc., a material obtained by separating and purifying cultured product produced from organ culture of root of Stephania is preferably used judging from viewpoints of production efficiency and easiness of isolation and purification process. The vasodilator expressed by the formula can be used also as an external preparation for hair nourishing or hair growing or bathing agent.

    PESTICIDE PREPARATION
    4.
    发明专利
    PESTICIDE PREPARATION 失效

    公开(公告)号：JPS5810503A

    公开(公告)日：1983-01-21

    申请号：JP10732781

    申请日：1981-07-09

    Applicant: KAO CORP

    Inventor： SUGIMURA YORIO ,  YAMAZAKI HARUMASA

    IPC: A01N25/10

    Abstract: PURPOSE:To obtain a granulated or tabletted agricultural, horticultural or forestry pesticide preparation which can transfer the pesticidal component easily to the soil and is dispersible widely and effectively in the ground, by using a pesticidal component, a water-absorbing polymer and a carrier as the components. CONSTITUTION:The objective pesticide preparation is composed of a pesticidal component (e.g. insecticide, bactericide, herbicide, etc.), a water-absorbing polymer (e.g. graft copolymer of starch and polyacrylonitrile, saponified copolymer of a vinyl ester and an ethylenically unsaturated carboxylic acid, etc.) and a carrier (e.g. pulp, bark, etc.). The composition is incorporated with a water- soluble polymer such as polyvinyl alcohol, methyl cellulose, etc. before granulation or tabletting.

    PROTOPLAST CULTURE OF BASIL
    8.
    发明专利
    PROTOPLAST CULTURE OF BASIL 失效

    公开(公告)号：JPH07327672A

    公开(公告)日：1995-12-19

    申请号：JP12757294

    申请日：1994-06-09

    Applicant: KAO CORP

    Inventor： KAGEYAMA YASUSHI ,  SUGIMURA YORIO

    IPC: A01H4/00 ,  C12N5/04

    Abstract: PURPOSE:To produce a refined oil useful as a raw material for cosmetics by culturing basil protoplasts in the presence of a suspension of basil-derived cells while efficiently forming colonies. CONSTITUTION:This method for culture of protoplast of a basil such as sweet basil is carried out, e.g. by cutting the leaves of a sweet basil aseptically grown in a test tube into pieces having 5 to 15mm width, culturing them on a solid medium to induce the callus, further carrying out subculture on the same medium, culturing the grown callus in a liquid medium, repeating subcultures every one week and carrying out culture in the presence of the obtained suspension of cells.

    BLOODSTREAM IMPROVER
    9.
    发明专利
    BLOODSTREAM IMPROVER 失效

    公开(公告)号：JPH04210630A

    公开(公告)日：1992-07-31

    申请号：JP40968990

    申请日：1990-12-11

    Applicant: KAO CORP

    Inventor： KAMIYA TETSURO ,  NISHIZAWA YOSHINORI ,  SUGIMURA YORIO

    IPC: A61K31/215 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10

    Abstract: PURPOSE:To obtain a bloodstream improver, containing an agathic acid or its salt as an active ingredient and useful for preventing and treating blood circulation insufficiency. CONSTITUTION:A bloodstream improver containing a compound expressed by the formula (R is lower alkyl), e.g. 15-methyl agathate or its salt as an active ingredient. The aforementioned compound has excellent peripheral vasodilator action and promoting action on vertebral arterial bloodstream and is useful as a treating and preventive agent for various diseases caused by blood circulation insufficiency, especially cerebral ischemic disorder.

    PRODUCTION OF ISOFLAVONOID
    10.
    发明专利
    PRODUCTION OF ISOFLAVONOID 失效

    公开(公告)号：JPH04190720A

    公开(公告)日：1992-07-09

    申请号：JP32440290

    申请日：1990-11-26

    Applicant: KAO CORP

    Inventor： SHIBUYA YUSUKE ,  SUGIMURA YORIO

    IPC: A01G7/06 ,  A61K36/00 ,  A61K36/48 ,  A61P25/18

    Abstract: PURPOSE:To obtain the subject compound containing little foreign substances with a simple extraction and purification operation in high yield by culturing a young seedling of a plant of family Leguminosae while treating with a stressing agent containing a water-soluble inorganic salt. CONSTITUTION:A young seedling of a plant of family Leguminosae is cultured while treating with a stressing agent containing preferably 0.01-50mM of a water-soluble inorganic salt [preferably AgNO3, FeSO4, FeCl3, Zn(NO3)2, Pb(NO3)2, SO(NO3)2, SnCl2, CoCl2, HgCl2, CuCl2 or CuSO4] and an isoflavonoid compound is separated from the cultured young seedling.

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