公开(公告)号：US20210300859A1

公开(公告)日：2021-09-30

申请号：US17254156

申请日：2019-06-19

Applicant: KAO CORPORATION

Inventor： Akihiro TAKAMURA ,  Naoya KITAMURA ,  Naoki YAMAMOTO ,  Kohjiro HASHIZUME

IPC: C07C69/736 ,  A23L33/105

Abstract: The present invention provides a compound that inhibits the activity of TRPV4 and is useful for prevention or amelioration of an overactive bladder, an irritable bowel syndrome, etc. The compound is a rosmarinic acid derivative represented by the following formula (I) or a salt thereof:

公开(公告)号：US20210212959A1

公开(公告)日：2021-07-15

申请号：US17057392

申请日：2019-05-22

Applicant: KAO CORPORATION

Inventor： Akihiro TAKAMURA ,  Yoshitaka KOGA ,  Kohjiro HASHIZUME ,  Takuya MORI

IPC: A61K31/047 ,  A23L29/30

Abstract: Provided is a GIP elevation inhibitor useful as, e.g., a pharmaceutical product and food. The GIP elevation inhibitor comprises mannitol as an active ingredient.

公开(公告)号：US20230225382A1

公开(公告)日：2023-07-20

申请号：US17998953

申请日：2021-05-28

Applicant: KAO CORPORATION

Inventor： Eri OZEKI ,  Akihiro TAKAMURA ,  Kohjiro HASHIZUME ,  Yoriko OOKI ,  Tomoya TAKAHASHI

IPC: A23L27/00 ,  A23L2/56

CPC classification number: A23L27/84 ,  A23L2/56

Abstract: An astringency reducing agent including an arabinogalactan which has a molecular weight of from 10,000 to 1,000,000 and a ratio of 1,3-bound galactose to total galactose of 12 mol % or more, as an active ingredient. A method for reducing astringency, including blending the astringency reducing agent into an oral product including an astringent substance.

公开(公告)号：US20220031790A1

公开(公告)日：2022-02-03

申请号：US17297299

申请日：2019-11-26

Applicant: KAO CORPORATION

Inventor： Akihiro TAKAMURA ,  Masazumi IWASHITA ,  Yuta YAMAMOTO ,  Kenji YAMAWAKI ,  Kohjiro HASHIZUME

IPC: A61K36/535 ,  A61K31/216 ,  A23L33/105

Abstract: Provided is a method for producing a red perilla leaf extract which enables to collect rosmarinic acid with a high yield from red perilla leaves to which an acid is added. The method for producing a red perilla leaf extract includes the following step (1): (1) a step of extracting red perilla leaves to which an acid has been added with water under a condition of a pH of from 4.0 to 8.0.