公开(公告)号：US20190183852A1

公开(公告)日：2019-06-20

申请号：US16322601

申请日：2017-08-01

Applicant: KAO CORPORATION

Inventor： Masazumi IWASHITA ,  Masahiro UMEHARA ,  Shintaro ONISHI ,  Masaki YAMAMOTO ,  Keisuke YAMAGAMI ,  Takaaki ISHIGAMI

IPC: A61K31/353 ,  A23L33/105 ,  A61K9/10 ,  A61K47/26

CPC classification number: A61K31/353 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/10 ,  A61K31/352 ,  A61K47/22 ,  A61K47/26 ,  A61P3/00 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00

Abstract: A nobiletin composition having high water solubility and a method for easily producing the same are provided. A method for producing a solid dispersion comprising nobiletin, comprising the step of mixing nobiletin or a nobiletin-containing product with a water-soluble hesperidin derivative, and then melting the mixture by heating; and the step of solidifying the melted product by cooling. A nobiletin-containing composition produced by the method.

公开(公告)号：US20210017144A1

公开(公告)日：2021-01-21

申请号：US17040245

申请日：2019-03-20

Applicant: KAO CORPORATION

Inventor： Masazumi IWASHITA ,  Takashi SUZUKI

IPC: C07D311/60

Abstract: Provided are a nobiletin composition having excellent solubility in water and a method for simply producing the same. A method for producing a solid dispersion containing nobiletin, the method involving a step of dissolving nobiletin or a nobiletin-containing substance and a water-soluble hesperidin derivative selected from the group consisting of glucosyl hesperidin and methyl hesperidin in an ethanol aqueous solution having an ethanol concentration of from 20 to 90 vol % and a step of drying the solution.

公开(公告)号：US20200261533A1

公开(公告)日：2020-08-20

申请号：US16646787

申请日：2018-09-21

Applicant: Kao Corporation

Inventor： Kotaro TAMURA ,  Masazumi IWASHITA ,  Yoshihiko MINEGISHI

IPC: A61K38/05 ,  A61K9/00 ,  A23L33/18

Abstract: Provided is a tyrosine formulation excellent in bioabsorbability of tyrosine when ingested orally. An oral formulation with improved bioabsorbability of tyrosine, including glycyltyrosine or a salt thereof or a solvate thereof.

公开(公告)号：US20220031790A1

公开(公告)日：2022-02-03

申请号：US17297299

申请日：2019-11-26

Applicant: KAO CORPORATION

Inventor： Akihiro TAKAMURA ,  Masazumi IWASHITA ,  Yuta YAMAMOTO ,  Kenji YAMAWAKI ,  Kohjiro HASHIZUME

IPC: A61K36/535 ,  A61K31/216 ,  A23L33/105

Abstract: Provided is a method for producing a red perilla leaf extract which enables to collect rosmarinic acid with a high yield from red perilla leaves to which an acid is added. The method for producing a red perilla leaf extract includes the following step (1): (1) a step of extracting red perilla leaves to which an acid has been added with water under a condition of a pH of from 4.0 to 8.0.

公开(公告)号：US20210346331A1

公开(公告)日：2021-11-11

申请号：US17284369

申请日：2019-10-09

Applicant: KAO CORPORATION

Inventor： Masazumi IWASHITA ,  Naoya KITAMURA

IPC: A61K31/222 ,  A23L33/10 ,  A61K9/00

Abstract: Provided is a compound that inhibits the activity of TRPV4 and is useful for preventing or ameliorating overactive bladder, irritable bowel syndrome, and the like. A TRPV4 activity inhibitor is provided containing a rosmarinic acid derivative selected from the group consisting of the following formulas (Ia) to (Id), or a salt thereof, as an active ingredient.