公开(公告)号：US20180186968A1

公开(公告)日：2018-07-05

申请号：US15737210

申请日：2016-06-16

Applicant: KAO CORPORATION

Inventor： Keiichi YOSHIKAWA ,  Naoko SAITO

IPC: C08K5/06 ,  C08K5/07 ,  C08K5/101 ,  C08K5/01

CPC classification number: C08K5/06 ,  A61L9/01 ,  C08K5/01 ,  C08K5/07 ,  C08K5/101 ,  C08K2201/007

Abstract: Provided an agent for suppressing an odor of a polysulfide compound. This agent for suppressing an odor of a polysulfide compound comprises, as an active ingredient, at least one selected from the group consisting, butyl 2-methylbutanoate, α-terpinene, dipentene, cis-4-heptenal, 1,4-cineol, trimethlhexyl aldehyde, and (+)-limoene oxide, wherein the polysulfide compound is represented by the following formula (I): R1-[S]n-R2 (I) (in the formula, R1 and R2 are the same or different, and each denote a linear-chain or branched-chain alkyl or alkenyl group having 1 to 6 carbon atoms, and n denotes an integer of 2 to 5).

公开(公告)号：US20180180600A1

公开(公告)日：2018-06-28

申请号：US15737079

申请日：2016-06-16

Applicant: KAO CORPORATION

Inventor： Keiichi YOSHIKAWA ,  Naoko SAITO

IPC: G01N33/53

CPC classification number: G01N33/53 ,  C12Q1/06 ,  F01N2560/027 ,  G01N33/5038 ,  G01N33/566

Abstract: The present invention identifies substances which suppress odors of sulfide compounds. Provided is a method for evaluating and/or selecting an agent for suppressing odors of sulfide compounds, the method comprising: adding a test substance and a sulfide compound to at least one olfactory receptor polypeptide selected from the group consisting of OR4S2 and polypeptides having an amino acid sequence identity of at least 80% to OR4S2; and measuring the response of the olfactory receptor polypeptide to the sulfide compound.

公开(公告)号：US20240279302A1

公开(公告)日：2024-08-22

申请号：US18571388

申请日：2022-06-20

Applicant: Kao Corporation

Inventor： Keiichi YOSHIKAWA

IPC: C07K14/705 ,  C12N15/10 ,  G01N33/68

CPC classification number: C07K14/705 ,  C12N15/1089 ,  G01N33/68

Abstract: Provided is an approach which can express an olfactory receptor and function. The present invention provides a method for expressing an olfactory receptor polypeptide, comprising expressing, in a cell, an olfactory receptor polypeptide consisting of an amino acid sequence obtained by, in an amino acid sequence of an olfactory receptor of interest, altering at least one amino acid residue different from that in a consensus amino acid sequence to the amino acid residue at a position corresponding thereto in the consensus amino acid sequence, wherein the consensus amino acid sequence is an amino acid sequence obtained by alignment of the amino acid sequence of the olfactory receptor of interest and amino acid sequences of particular olfactory receptors.

公开(公告)号：US20230321462A1

公开(公告)日：2023-10-12

申请号：US17780633

申请日：2020-12-14

Applicant: Kao Corporation

Inventor： Dan TAKASE ,  Keiichi YOSHIKAWA ,  Masatoshi OHASHI

IPC: A61Q15/00 ,  A61B5/00

CPC classification number: A61Q15/00 ,  A61B5/4011

Abstract: The improvement of olfactory sensitivity. A method for improving olfactory sensitivity, comprising reducing body odor.

公开(公告)号：US20160198746A1

公开(公告)日：2016-07-14

申请号：US14917178

申请日：2014-08-01

Applicant: KAO CORPORATION

Inventor： Masanori MATSUURA ,  Tomohiro NAKAGAWA ,  Keiichi YOSHIKAWA

IPC: A61K31/225 ,  C07C305/14 ,  A23L1/236

CPC classification number: C07C305/14 ,  A23L27/39 ,  A23L27/88 ,  A23V2002/00

Abstract: Provided are a novel compound useful for adjusting sweetness or saltiness or inhibiting ENaC, and use thereof.An octenyl sulfate ester of the following Formula (1) or a salt thereof, wherein the wavy line represents any one of cis- or trans-configuration.

Abstract translation: 提供了一种用于调节甜度或盐度或抑制ENaC的新型化合物及其用途。 下式（1）的辛烯基硫酸酯或其盐，其中波浪线表示顺式或反式构型中的任何一种。