公开(公告)号：US20180180600A1

公开(公告)日：2018-06-28

申请号：US15737079

申请日：2016-06-16

Applicant: KAO CORPORATION

Inventor： Keiichi YOSHIKAWA ,  Naoko SAITO

IPC: G01N33/53

CPC classification number: G01N33/53 ,  C12Q1/06 ,  F01N2560/027 ,  G01N33/5038 ,  G01N33/566

Abstract: The present invention identifies substances which suppress odors of sulfide compounds. Provided is a method for evaluating and/or selecting an agent for suppressing odors of sulfide compounds, the method comprising: adding a test substance and a sulfide compound to at least one olfactory receptor polypeptide selected from the group consisting of OR4S2 and polypeptides having an amino acid sequence identity of at least 80% to OR4S2; and measuring the response of the olfactory receptor polypeptide to the sulfide compound.

公开(公告)号：US20180127482A1

公开(公告)日：2018-05-10

申请号：US15576514

申请日：2016-05-27

Applicant: Kao Corporation

Inventor： Keiichi Yoshikawa ,  Naoko SAITO

IPC: C07K14/705 ,  G01N33/53 ,  A61B5/00

CPC classification number: C07K14/70571 ,  A61B5/4011 ,  C07K14/705 ,  G01N33/53 ,  G01N33/566 ,  G01N2500/10

Abstract: A method for searching for a substance suppressing a target odor through cross-adaptation is provided. A method for selecting a substance inducing cross-adaptation of a target odor includes: searching olfactory receptor polypeptides to identify an olfactory receptor polypeptide responding to a causative substance of the target odor; adding a test substance, which is different from the causative substance of the target odor, to the identified olfactory receptor polypeptide to measure response thereof; and selecting the test substance which activates the response of the olfactory receptor polypeptide as the substance inducing the cross-adaptation of the target odor.

公开(公告)号：US20180186968A1

公开(公告)日：2018-07-05

申请号：US15737210

申请日：2016-06-16

Applicant: KAO CORPORATION

Inventor： Keiichi YOSHIKAWA ,  Naoko SAITO

IPC: C08K5/06 ,  C08K5/07 ,  C08K5/101 ,  C08K5/01

CPC classification number: C08K5/06 ,  A61L9/01 ,  C08K5/01 ,  C08K5/07 ,  C08K5/101 ,  C08K2201/007

Abstract: Provided an agent for suppressing an odor of a polysulfide compound. This agent for suppressing an odor of a polysulfide compound comprises, as an active ingredient, at least one selected from the group consisting, butyl 2-methylbutanoate, α-terpinene, dipentene, cis-4-heptenal, 1,4-cineol, trimethlhexyl aldehyde, and (+)-limoene oxide, wherein the polysulfide compound is represented by the following formula (I): R1-[S]n-R2 (I) (in the formula, R1 and R2 are the same or different, and each denote a linear-chain or branched-chain alkyl or alkenyl group having 1 to 6 carbon atoms, and n denotes an integer of 2 to 5).