公开(公告)号：WO2019069224A1

公开(公告)日：2019-04-11

申请号：PCT/IB2018/057638

申请日：2018-10-02

Applicant: KHALIFA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： TEO, Jeremy CM ,  STEFANINI, Cesare ,  ABDULLAH, Amal ,  SAMARA, Bisan ,  SHANTI, Aya

IPC: B01L3/00

Abstract: There is provided a microfluidic device for an in vitro lymph node. The microfluidic device disclosed in the present invention, has a body with a semi-circular inner wall and a first channel located adjacent along the semi-circular inner wall. The first channel of the microfluidic device disclosed corresponds to a subcapsular sinus region of a lymph node. The device also has a second channel located adjacent the first channel, which corresponds to a reticular network. A bottom cavity and top cavity, centrally located, corresponding to a paracortex and follicle of a lymph node, respectively. The various compartments of the device are separated by circumferentially and horizontally located rows of micro-pillars. The microfluidic device of the present invention is fabricated with a polysiloxane, preferably polydimethylsiloxane (PDMS). There is also provided in the present invention a lab-on-a-chip device incorporating multiple immune cell types within a collagen rich silicone microfluidic device.

公开(公告)号：WO2021234604A1

公开(公告)日：2021-11-25

申请号：PCT/IB2021/054335

申请日：2021-05-19

Applicant: KHALIFA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： STEFANINI, Cesare ,  AL FALAHI, Hessa ,  RENDA, Federico

IPC: A61M25/01 ,  A61B17/00

Abstract: A robotic catheter can include bi-stable concentric tubes and a torsional spring mechanism that can provide torque at the proximal extremity of one or more tubes. The robotic catheter can compensate for the energy that may be released by the tubes snapping from on stable- equilibrium position to another by using the energy stored in the torsional spring mechanism. The energy released by the tubes upon snapping from one stable-equilibrium position to the other can be compensated by the energy stored in the torsional spring at the base, thereby resulting in the first, energy-free, zero stiffness catheter system that (1) synchronizes with the motion of the heart and (2) naturally results in optimal, pseudo-constant contact force with the tissue.

公开(公告)号：EP3691790A1

公开(公告)日：2020-08-12

申请号：EP18864125.2

申请日：2018-10-02

Applicant: Khalifa University of Science and Technology

Inventor： TEO, Jeremy CM ,  STEFANINI, Cesare ,  ABDULLAH, Amal ,  SAMARA, Bisan ,  SHANTI, Aya

IPC: B01L3/00