公开(公告)号：WO2019069224A1

公开(公告)日：2019-04-11

申请号：PCT/IB2018/057638

申请日：2018-10-02

Applicant: KHALIFA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： TEO, Jeremy CM ,  STEFANINI, Cesare ,  ABDULLAH, Amal ,  SAMARA, Bisan ,  SHANTI, Aya

IPC: B01L3/00

Abstract: There is provided a microfluidic device for an in vitro lymph node. The microfluidic device disclosed in the present invention, has a body with a semi-circular inner wall and a first channel located adjacent along the semi-circular inner wall. The first channel of the microfluidic device disclosed corresponds to a subcapsular sinus region of a lymph node. The device also has a second channel located adjacent the first channel, which corresponds to a reticular network. A bottom cavity and top cavity, centrally located, corresponding to a paracortex and follicle of a lymph node, respectively. The various compartments of the device are separated by circumferentially and horizontally located rows of micro-pillars. The microfluidic device of the present invention is fabricated with a polysiloxane, preferably polydimethylsiloxane (PDMS). There is also provided in the present invention a lab-on-a-chip device incorporating multiple immune cell types within a collagen rich silicone microfluidic device.

公开(公告)号：EP3691790A1

公开(公告)日：2020-08-12

申请号：EP18864125.2

申请日：2018-10-02

Applicant: Khalifa University of Science and Technology

Inventor： TEO, Jeremy CM ,  STEFANINI, Cesare ,  ABDULLAH, Amal ,  SAMARA, Bisan ,  SHANTI, Aya

IPC: B01L3/00