公开(公告)号：EP3088896A4

公开(公告)日：2017-06-07

申请号：EP13900340

申请日：2013-12-27

Applicant: KONICA MINOLTA INC

Inventor： YAMASHITA KATSUKO ,  KAYA TAKATOSHI ,  IDE YOUICHI ,  KANEKO TOMONORI

IPC: G01N33/68 ,  G01N33/53 ,  G01N33/574

CPC classification number: G01N33/57434 ,  G01N33/6893 ,  G01N2333/42 ,  G01N2333/4725 ,  G01N2800/342

Abstract: An object of the present invention is to provide: a novel method of analyzing diagnostic information, by which prostate cancer and a benign prostate disease can be distinguished from one another with high accuracy; and a diagnostic kit for obtaining the diagnostic information. One embodiment of the method of analyzing diagnostic information according to the present invention is a method of analyzing diagnostic information, which includes: measuring the concentration of a mucin-1 (Tn-MUC1), which is reactive with a lectin that recognizes and binds to an N -acetyl-D-galactosamine †’ serine (threonine) residue, in a blood sample originated from a subject to be diagnosed; comparing the thus measured value with a threshold value; and estimating that a disease affecting the subject to be diagnosed is not prostate cancer but a benign prostate disease when the measured value of the concentration of the mucin-1 is greater than the threshold value, and one embodiment of the diagnostic kit according to the present invention is a diagnostic kit including: an anti-mucin-1 antibody for quantifying Tn-MUC1; and a lectin for detection, which recognizes and binds to an N -acetyl-D-galactosamine †’ serine (threonine) residue.

Abstract translation: 本发明的一个目的是提供：一种分析诊断信息的新方法，通过该方法可以高精度地区分前列腺癌和良性前列腺疾病; 以及用于获得诊断信息的诊断工具。 根据本发明分析诊断信息的方法的一个实施例是一种分析诊断信息的方法，其包括：测量与识别和结合的凝集素反应的粘蛋白-1（Tn-MUC1）的浓度 来源于待诊断受试者的血液样品中的N-乙酰基-D-半乳糖胺†丝氨酸（苏氨酸）残基; 将如此测量的值与阈值进行比较; 并且当粘蛋白-1的浓度的测量值大于阈值时，估计影响要诊断的对象的疾病不是前列腺癌而是良性前列腺疾病，并且根据本发明的诊断试剂盒的一个实施方案 本发明是一种诊断试剂盒，包括：用于定量Tn-MUC1的抗粘蛋白-1抗体; 和用于检测的凝集素，其识别并结合N-乙酰-D-半乳糖胺†丝氨酸（苏氨酸）残基。

公开(公告)号：EP2738556A4

公开(公告)日：2015-04-08

申请号：EP12818464

申请日：2012-07-24

Applicant: KONICA MINOLTA INC

Inventor： IDE YOUICHI ,  KANEKO TOMONORI ,  NINOMIYA HIDETAKA

IPC: G01N33/543 ,  G01N21/64 ,  G01N21/78 ,  G01N33/545 ,  G01N33/566 ,  G01N33/574

CPC classification number: G01N33/544 ,  G01N21/648 ,  G01N33/54373 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2333/42

Abstract: [Problem] An object of the present invention is to provide a method by which the amount of a very small amount of analyte (in particular, one having a sugar chain) can be measured with a high accuracy and a device which is used for said measurement method. [Means for Solution] The method for measuring the amount of an analyte according to the present invention is characterized in that a lectin labeled with a fluorescent dye, preferably said lectin whose dissociation rate constant [k d ] is from 1.0 x 10 -6 to 1.0 x 10 -3 (S -1 ), is used as a secondary antibody in a sandwich assay using a surface plasmon excitation enhanced fluorescence spectroscopy [SPFS; Surface Plasmon-field enhanced Fluorescence Spectroscopy].

公开(公告)号：EP3088895A4

公开(公告)日：2017-08-09

申请号：EP13900337

申请日：2013-12-27

Applicant: KONICA MINOLTA INC

Inventor： YAMASHITA KATSUKO ,  KAYA TAKATOSHI ,  IDE YOUICHI ,  KANEKO TOMONORI

IPC: G01N33/68 ,  G01N33/574

CPC classification number: G01N33/6893 ,  G01N33/573 ,  G01N33/57434 ,  G01N2333/4725 ,  G01N2333/705 ,  G01N2333/96455 ,  G01N2800/342

公开(公告)号：EP2843412A4

公开(公告)日：2015-09-30

申请号：EP13780782

申请日：2013-04-15

Applicant: KONICA MINOLTA INC

Inventor： KANEKO TOMONORI ,  IDE YOUICHI

IPC: G01N33/53 ,  C12Q1/34 ,  G01N33/574

CPC classification number: G01N33/566 ,  C12Q1/34 ,  G01N33/5308 ,  G01N2333/42 ,  G01N2333/4724

Abstract: Provided are: an antigen detection method which can improve the detection sensitivity and quantitative performance for a sugar chain on an antigen to be detected with a lectin by a simple technique (simple constitution) in a sugar chain detection system using a lectin; and a detection kit. The antigen detection method of the present invention is a method of detecting an antigen having a specific sugar chain in a sample with a lectin that binds to plural kinds of sugar chains including the specific sugar chain, and the detection method comprises: a first step of bringing the lectin into contact with the sample; a second step of bringing a glycohydrolase capable of cleaving at least one kind of sugar chain to which the lectin can bind into contact with the sample, the at least one kind of sugar chain excluding the specific sugar chain among the plural kinds of sugar chains; and a fourth step of detecting the antigen bound with the lectin after the first and second steps.