公开(公告)号：EP3088895A4

公开(公告)日：2017-08-09

申请号：EP13900337

申请日：2013-12-27

Applicant: KONICA MINOLTA INC

Inventor： YAMASHITA KATSUKO ,  KAYA TAKATOSHI ,  IDE YOUICHI ,  KANEKO TOMONORI

IPC: G01N33/68 ,  G01N33/574

CPC classification number: G01N33/6893 ,  G01N33/573 ,  G01N33/57434 ,  G01N2333/4725 ,  G01N2333/705 ,  G01N2333/96455 ,  G01N2800/342

公开(公告)号：EP3088896A4

公开(公告)日：2017-06-07

申请号：EP13900340

申请日：2013-12-27

Applicant: KONICA MINOLTA INC

Inventor： YAMASHITA KATSUKO ,  KAYA TAKATOSHI ,  IDE YOUICHI ,  KANEKO TOMONORI

IPC: G01N33/68 ,  G01N33/53 ,  G01N33/574

CPC classification number: G01N33/57434 ,  G01N33/6893 ,  G01N2333/42 ,  G01N2333/4725 ,  G01N2800/342

Abstract: An object of the present invention is to provide: a novel method of analyzing diagnostic information, by which prostate cancer and a benign prostate disease can be distinguished from one another with high accuracy; and a diagnostic kit for obtaining the diagnostic information. One embodiment of the method of analyzing diagnostic information according to the present invention is a method of analyzing diagnostic information, which includes: measuring the concentration of a mucin-1 (Tn-MUC1), which is reactive with a lectin that recognizes and binds to an N -acetyl-D-galactosamine †’ serine (threonine) residue, in a blood sample originated from a subject to be diagnosed; comparing the thus measured value with a threshold value; and estimating that a disease affecting the subject to be diagnosed is not prostate cancer but a benign prostate disease when the measured value of the concentration of the mucin-1 is greater than the threshold value, and one embodiment of the diagnostic kit according to the present invention is a diagnostic kit including: an anti-mucin-1 antibody for quantifying Tn-MUC1; and a lectin for detection, which recognizes and binds to an N -acetyl-D-galactosamine †’ serine (threonine) residue.

Abstract translation: 本发明的一个目的是提供：一种分析诊断信息的新方法，通过该方法可以高精度地区分前列腺癌和良性前列腺疾病; 以及用于获得诊断信息的诊断工具。 根据本发明分析诊断信息的方法的一个实施例是一种分析诊断信息的方法，其包括：测量与识别和结合的凝集素反应的粘蛋白-1（Tn-MUC1）的浓度 来源于待诊断受试者的血液样品中的N-乙酰基-D-半乳糖胺†丝氨酸（苏氨酸）残基; 将如此测量的值与阈值进行比较; 并且当粘蛋白-1的浓度的测量值大于阈值时，估计影响要诊断的对象的疾病不是前列腺癌而是良性前列腺疾病，并且根据本发明的诊断试剂盒的一个实施方案 本发明是一种诊断试剂盒，包括：用于定量Tn-MUC1的抗粘蛋白-1抗体; 和用于检测的凝集素，其识别并结合N-乙酰-D-半乳糖胺†丝氨酸（苏氨酸）残基。