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公开(公告)号：US20220084804A1
公开(公告)日：2022-03-17
申请号：US17426573
申请日：2019-12-30
Inventor： Tae Geol LEE , Hee-Kyung NA , Sunho JOH
Abstract: A method for detecting organic matter in the blood by using LDI-MS, and a device therefor, according to the present invention, are not complicated when performing measurement and do not require the passage of many steps, and facilitate, in real time, measurement and result collection through rapid analysis. In addition, the present invention enables precise analysis even at a lower sample concentration so as to have excellent sensitivity and accuracy, enables the detection of various types of organic matter at the same time and has high throughput, and enables the structure analysis of organic matter, having undergone metabolic processes in the blood, and quantitative analysis thereof to be accurately performed without interference from a matrix.
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公开(公告)号：US20210318304A1
公开(公告)日：2021-10-14
申请号：US17271699
申请日：2018-09-03
Inventor： Tae Geol LEE , Hee-Kyung NA
IPC: G01N33/553 , G01N27/62 , G01N33/53
Abstract: The present invention relates to a method for high-sensitivity and high-specificity detection of biomolecules by using mass spectrometry and, more specifically, to a method for high-sensitivity and high-specificity detection of proteins such as miRNA or antigens by using time-of-flight secondary ion mass spectrometry (ToF-SIMS), matrix-assisted laser desorption/ionization (MALDI), or laser desorption/ionization (LDI) mass spectrometry. The method for high-sensitivity and high-specificity detection of biomolecules by using mass spectrometry, according to the present invention, enables high-sensitivity and high-specificity detection of biomolecules by using surface mass spectrometry, and the method is expected to be used for the diagnosis and prediction of diseases by quantifying, from a biosample, a target probe such as miRNA which is known as a disease marker.
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