公开(公告)号：US20220283189A1

公开(公告)日：2022-09-08

申请号：US17637302

申请日：2019-11-11

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Tae Geol LEE ,  Jin Gyeong SON ,  Sunho JOH

IPC: G01N33/82 ,  G01N21/31 ,  G01N30/72

Abstract: A method of detecting vitamin D in blood using laser desorption/ionization mass spectrometry (LDI-MS) and an apparatus therefor according to the present invention are not complicated in a measurement, do not require a number of measurement steps, and allow for easy measurement and collection of results in real time with a quick analysis. In addition, precise analysis may be performed even at a lower concentration of a sample, such that sensitivity and precision are excellent, various subtypes of vitamin D may be simultaneously detected, a throughput is high, and structural analysis and quantitative analysis of vitamin D that has undergone a metabolic process in blood may be accurately performed without a matrix interference.

公开(公告)号：US20220084804A1

公开(公告)日：2022-03-17

申请号：US17426573

申请日：2019-12-30

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Tae Geol LEE ,  Hee-Kyung NA ,  Sunho JOH

IPC: H01J49/04 ,  H01J49/00 ,  G01N33/94

Abstract: A method for detecting organic matter in the blood by using LDI-MS, and a device therefor, according to the present invention, are not complicated when performing measurement and do not require the passage of many steps, and facilitate, in real time, measurement and result collection through rapid analysis. In addition, the present invention enables precise analysis even at a lower sample concentration so as to have excellent sensitivity and accuracy, enables the detection of various types of organic matter at the same time and has high throughput, and enables the structure analysis of organic matter, having undergone metabolic processes in the blood, and quantitative analysis thereof to be accurately performed without interference from a matrix.