公开(公告)号：US10406110B2

公开(公告)日：2019-09-10

申请号：US15743895

申请日：2016-07-12

Applicant: SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION ,  KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Jeong Hun Kim ,  Dong Hyun Jo ,  Tae Geol Lee

IPC: A61K9/14 ,  A61K9/51 ,  A61K47/42 ,  A61P27/02 ,  B82Y5/00 ,  G01N33/15 ,  G01N33/68 ,  A61K9/50 ,  A61K9/16 ,  A61K33/00 ,  A61K33/24 ,  G01N33/50 ,  A61K47/69 ,  A61P27/00 ,  A61K9/00 ,  A61K38/38 ,  B82Y30/00

Abstract: Provided is a nanoparticle-vitreous body-based protein complex, and more particularly, to a composition for inhibiting angiogenesis which includes the complex as an active ingredient, and a composition for preventing or treating an angiogenesis-related disease or a retinal disease. When the nanoparticle-vitreous body-based protein complex according to the subject matter is locally injected into the vitreous body, the complex exhibits significantly excellent binding strength with a vascular endothelial growth factor and thus can inhibit angiogenesis, thus being easily used to prepare a therapeutic agent for preventing, alleviating, or treating retinal and choroidal angiogenesis-related diseases.

公开(公告)号：US09238006B2

公开(公告)日：2016-01-19

申请号：US13623497

申请日：2012-09-20

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Tae Geol Lee ,  Jeong Hun Kim ,  Dong Hyun Jo

IPC: A61K9/14 ,  A61K33/24 ,  A61K33/00 ,  A61P27/02 ,  A61P9/10 ,  C01G23/047 ,  B82Y5/00 ,  C01B33/18

CPC classification number: A61K9/14 ,  A61K33/00 ,  A61K33/24 ,  B82Y5/00 ,  C01B33/18 ,  Y10T428/2982 ,  A61K2300/00

Abstract: Provided is a pharmaceutical composition containing inorganic nanoparticles selected from titanium oxide nanoparticles or silica nanoparticles as an active ingredient for preventing or treating angiogenesis-related diseases. The pharmaceutical composition for preventing or treating angiogenesis-related diseases according to the present invention may be used as a therapeutic agent for various diseases based on angiogenesis such as age-related macular degeneration, tumors, and diabetes-related complications.

Abstract translation: 本发明提供含有选自氧化钛纳米粒子或二氧化硅纳米粒子的无机纳米粒子作为预防或治疗血管发生相关疾病的有效成分的药物组合物。 根据本发明的用于预防或治疗血管生成相关疾病的药物组合物可以用作基于血管生成的各种疾病的治疗剂，例如年龄相关性黄斑变性，肿瘤和糖尿病相关并发症。