公开(公告)号：US12270762B2

公开(公告)日：2025-04-08

申请号：US16982850

申请日：2019-09-18

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah You ,  Wansun Kim ,  Tae Geol Lee

IPC: G01N21/65 ,  B82B1/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N33/483 ,  G01N33/553

Abstract: Provided is a Raman-active particle which is a Raman-active particle for surface-enhanced Raman analysis, the particle including: a spherical plasmonic metal core; a plasmonic metal shell having surface unevenness; and a self-assembled monolayer which is bonded to each of the core and the shell and positioned between the core and the shell, and includes a Raman reporter.

公开(公告)号：US11592441B2

公开(公告)日：2023-02-28

申请号：US16216306

申请日：2018-12-11

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE ,  FOUNDATION FOR RESEARCH AND BUSINESS, SEOUL NATIONAL UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Tae Geol Lee ,  Hee Kyung Na ,  Jung Sub Wi ,  Jong G. OK

IPC: G01N33/543 ,  G01N21/552 ,  G01N21/77

Abstract: Provided is a nanoplasmonic sensor and a kit for biomolecule analysis, and a method of analyzing a biomolecule using the same. The method includes: providing the nanoplasmonic sensor including a dielectric grating extending in one direction, and a metal structure disposed to cover an upper surface and a side surface of the dielectric grating and have at least one bent portion; immobilizing a first probe molecule on a surface of the metal structure; hybridizing an analyte with the first probe molecule by introducing the analyte having a base sequence complementary to the first probe molecule; binding a second probe molecule that is hybridized with the first probe molecule to the analyte; binding an enzyme to the second probe molecule; introducing a substrate that reacts with the enzyme to produce a precipitate by an enzymatic reaction; and measuring localized surface plasmon resonance in the metal structure.

公开(公告)号：US12196767B2

公开(公告)日：2025-01-14

申请号：US17637302

申请日：2019-11-11

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Tae Geol Lee ,  Jin Gyeong Son ,  Sunho Joh

IPC: H01J49/04 ,  G01N21/31 ,  G01N30/72 ,  G01N33/82

Abstract: A method of detecting vitamin D in blood using laser desorption/ionization mass spectrometry (LDI-MS) and an apparatus therefor according to the present invention are not complicated in a measurement, do not require a number of measurement steps, and allow for easy measurement and collection of results in real time with a quick analysis. In addition, precise analysis may be performed even at a lower concentration of a sample, such that sensitivity and precision are excellent, various subtypes of vitamin D may be simultaneously detected, a throughput is high, and structural analysis and quantitative analysis of vitamin D that has undergone a metabolic process in blood may be accurately performed without a matrix interference.

公开(公告)号：US12033841B2

公开(公告)日：2024-07-09

申请号：US17426573

申请日：2019-12-30

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Tae Geol Lee ,  Hee-Kyung Na ,  Sunho Joh

IPC: H01J49/04 ,  G01N33/94 ,  H01J49/00

CPC classification number: H01J49/0418 ,  G01N33/9493 ,  H01J49/0031

Abstract: A method for detecting organic matter in the blood by using LDI-MS, and a device therefor, according to the present invention, are not complicated when performing measurement and do not require the passage of many steps, and facilitate, in real time, measurement and result collection through rapid analysis. In addition, the present invention enables precise analysis even at a lower sample concentration so as to have excellent sensitivity and accuracy, enables the detection of various types of organic matter at the same time and has high throughput, and enables the structure analysis of organic matter, having undergone metabolic processes in the blood, and quantitative analysis thereof to be accurately performed without interference from a matrix.

公开(公告)号：US11992297B2

公开(公告)日：2024-05-28

申请号：US17164686

申请日：2021-02-01

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Ik Hwan Kwon ,  Tae Geol Lee ,  Sang Won Lee

IPC: A61B5/00 ,  A01K1/03 ,  A01K61/00 ,  A61B5/024 ,  A61D3/00 ,  G03H1/04

CPC classification number: A61B5/024 ,  A01K1/031 ,  A01K61/00 ,  A61D3/00 ,  G03H1/0443 ,  A61B2503/40

Abstract: Provided is a method of monitoring a heart rate of an open circulatory system aquatic organism including water fleas, zebrafish, brine shrimp, and the method of evaluating individual response by real time measurement of a heart rate of an aquatic organism and the individual response evaluation apparatus by real time measurement of a heart rate of an aquatic organism according to the present invention may effectively fix the aquatic organism for real time measurement of the heart rate of an aquatic organism, and may measure the heart rate using digital holography to display the heart rate while configuring a data format to allow the corresponding data to be stored for a long time, thereby treating a compound for inducing an individual response, securing a heart rate change in real time by image processing, and then effectively determining the presence or absence of harmfulness due to induction of the individual response.

公开(公告)号：US12013393B2

公开(公告)日：2024-06-18

申请号：US16498326

申请日：2018-10-10

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah You ,  Wansun Kim ,  Tae Geol Lee

IPC: G01N33/553 ,  B82Y30/00 ,  G01N33/543 ,  B82B1/00 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  G01N21/65

CPC classification number: G01N33/54346 ,  G01N33/553 ,  B82B1/008 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  G01N21/658

Abstract: Provided is a method of preparing Raman-active nanoparticles, which includes a) preparing a metal nanocore having a nano-star shape from a first reaction solution in which a first metal precursor is mixed with a buffer solution; b) fixing a Raman reporter in the metal nanocore; and c) forming a metal shell, which surrounds the nanocore in which the Raman reporter is fixed, from a second reaction solution in which a second metal precursor is mixed with the nanocore in which the Raman reporter is fixed. The Raman reporter has a binding affinity for each of a first metal of the metal nanocore and a second metal of the metal shell.

公开(公告)号：US11479474B2

公开(公告)日：2022-10-25

申请号：US16498307

申请日：2018-10-23

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Eun-Ah You ,  Wansun Kim ,  Tae Geol Lee

IPC: C01G7/00 ,  G01N21/65 ,  B82B1/00 ,  G01N33/543 ,  G01N33/553 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

Abstract: Provided is a method of preparing composite nanoparticles, which includes: a) preparing a metal nanocore having a nano-star shape from a first reaction solution in which a first metal precursor is mixed with a first buffer solution; b) fixing a Raman reporter in the metal nanocore; and c) forming a metal shell, which surrounds the nanocore in which the Raman reporter is fixed, from a second reaction solution in which the nanocore in which the Raman reporter is fixed, and a second metal precursor are mixed with a second buffer solution.

公开(公告)号：US08742336B2

公开(公告)日：2014-06-03

申请号：US13727018

申请日：2012-12-26

Applicant: Korea Research Institute of Standards and Science

Inventor： Young-Pil Kim ,  Tae Geol Lee

IPC: H01J49/04

CPC classification number: H01J49/0409 ,  B82Y15/00 ,  G01N1/00 ,  H01J49/00 ,  H01J49/26 ,  Y10S977/902

Abstract: There are provided a bio-chip for secondary ion mass spectrometry and a method of fabricating the same, the bio-chip, which is a bio-chip for analyzing a biochemical material using the secondary ion mass spectrometry, including: a substrate; and core-shell particles positioned above substrate, wherein the core-shell particles each include a metal nanoparticle as a core and a metal shell surrounding the metal nanoparticle.

Abstract translation: 提供了二次离子质谱法的生物芯片及其制造方法，该生物芯片是使用二次离子质谱法分析生化材料的生物芯片，其包括：底物; 以及位于基材上方的核 - 壳颗粒，其中核 - 壳颗粒各自包括作为芯的金属纳米颗粒和围绕金属纳米颗粒的金属壳。

公开(公告)号：US10406110B2

公开(公告)日：2019-09-10

申请号：US15743895

申请日：2016-07-12

Applicant: SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION ,  KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Jeong Hun Kim ,  Dong Hyun Jo ,  Tae Geol Lee

IPC: A61K9/14 ,  A61K9/51 ,  A61K47/42 ,  A61P27/02 ,  B82Y5/00 ,  G01N33/15 ,  G01N33/68 ,  A61K9/50 ,  A61K9/16 ,  A61K33/00 ,  A61K33/24 ,  G01N33/50 ,  A61K47/69 ,  A61P27/00 ,  A61K9/00 ,  A61K38/38 ,  B82Y30/00

Abstract: Provided is a nanoparticle-vitreous body-based protein complex, and more particularly, to a composition for inhibiting angiogenesis which includes the complex as an active ingredient, and a composition for preventing or treating an angiogenesis-related disease or a retinal disease. When the nanoparticle-vitreous body-based protein complex according to the subject matter is locally injected into the vitreous body, the complex exhibits significantly excellent binding strength with a vascular endothelial growth factor and thus can inhibit angiogenesis, thus being easily used to prepare a therapeutic agent for preventing, alleviating, or treating retinal and choroidal angiogenesis-related diseases.

公开(公告)号：US09238006B2

公开(公告)日：2016-01-19

申请号：US13623497

申请日：2012-09-20

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE

Inventor： Tae Geol Lee ,  Jeong Hun Kim ,  Dong Hyun Jo

IPC: A61K9/14 ,  A61K33/24 ,  A61K33/00 ,  A61P27/02 ,  A61P9/10 ,  C01G23/047 ,  B82Y5/00 ,  C01B33/18

CPC classification number: A61K9/14 ,  A61K33/00 ,  A61K33/24 ,  B82Y5/00 ,  C01B33/18 ,  Y10T428/2982 ,  A61K2300/00

Abstract: Provided is a pharmaceutical composition containing inorganic nanoparticles selected from titanium oxide nanoparticles or silica nanoparticles as an active ingredient for preventing or treating angiogenesis-related diseases. The pharmaceutical composition for preventing or treating angiogenesis-related diseases according to the present invention may be used as a therapeutic agent for various diseases based on angiogenesis such as age-related macular degeneration, tumors, and diabetes-related complications.

Abstract translation: 本发明提供含有选自氧化钛纳米粒子或二氧化硅纳米粒子的无机纳米粒子作为预防或治疗血管发生相关疾病的有效成分的药物组合物。 根据本发明的用于预防或治疗血管生成相关疾病的药物组合物可以用作基于血管生成的各种疾病的治疗剂，例如年龄相关性黄斑变性，肿瘤和糖尿病相关并发症。