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公开(公告)号：DK0653426T3
公开(公告)日：1998-10-26
申请号：DK94117102
申请日：1994-10-28
Applicant: KOWA CO
Inventor： KYOTANI YOSHINORI , KAWAMINE KATSUMI , TOMA TSUTOMU , OHGIYA TADAAKI , YAMAGUCHI TAKASHI , ONOGI KAZUHIRO , SATO SEIICHI , SHIMIZU NOBORU , SHIGYO HIROMICHI , OHTA TOMIO , ODA TOSHIAKI , OKUNO YUKIHIRO , SHIBUYA KIMIYUKI , TAKAHASHI YOSHIO , FUJII MIKIO , UCHIDA YASUMI
IPC: A61K31/40 , C07D491/04 , C07D491/048
Abstract: An indole derivative represented by formula (1), wherein A is a group or wherein R is hydrogen or lower alkyl, dotted lines may optionally be resent, and R -R represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
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公开(公告)号：DE69411852D1
公开(公告)日：1998-08-27
申请号：DE69411852
申请日：1994-10-28
Applicant: KOWA CO
Inventor： KYOTANI YOSHINORI , KAWAMINE KATSUMI , TOMA TSUTOMU , OHGIYA TADAAKI , YAMAGUCHI TAKASHI , ONOGI KAZUHIRO , SATO SEIICHI , SHIMIZU NOBORU , SHIGYO HIROMICHI , OHTA TOMIO , ODA TOSHIAKI , OKUNO YUKIHIRO , SHIBUYA KIMIYUKI , TAKAHASHI YOSHIO , FUJII MIKIO , UCHIDA YASUMI
IPC: A61K31/40 , C07D491/04 , C07D491/048
Abstract: An indole derivative represented by formula (1), wherein A is a group or wherein R is hydrogen or lower alkyl, dotted lines may optionally be resent, and R -R represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
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3.发明专利
公开(公告)号：SI0653426T1
公开(公告)日：1998-12-31
申请号：SI9430179
申请日：1994-10-28
Applicant: KOWA CO
Inventor： KYOTANI YOSHINORI , KAWAMINE KATSUMI , TOMA TSUTOMU , OHGIYA TADAAKI , YAMAGUCHI TAKASHI , ONOGI KAZUHIRO , SATO SEIICHI , SHIMIZU NOBORU , SHIGYO HIROMICHI , OHTA TOMIO , ODA TOSHIAKI , OKUNO YUKIHIRO , SHIBUYA KIMIYUKI , TAKAHASHI YOSHIO , FUJII MIKIO , UCHIDA YASUMI
IPC: A61K31/40 , C07D491/04 , C07D491/048
Abstract: An indole derivative represented by formula (1), wherein A is a group or wherein R is hydrogen or lower alkyl, dotted lines may optionally be resent, and R -R represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
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Patent Agency Ranking
公开(公告)号：DE69411852T2
公开(公告)日：1998-12-03
申请号：DE69411852
申请日：1994-10-28
Applicant: KOWA CO
Inventor： KYOTANI YOSHINORI , KAWAMINE KATSUMI , TOMA TSUTOMU , OHGIYA TADAAKI , YAMAGUCHI TAKASHI , ONOGI KAZUHIRO , SATO SEIICHI , SHIMIZU NOBORU , SHIGYO HIROMICHI , OHTA TOMIO , ODA TOSHIAKI , OKUNO YUKIHIRO , SHIBUYA KIMIYUKI , TAKAHASHI YOSHIO , FUJII MIKIO , UCHIDA YASUMI
IPC: A61K31/40 , C07D491/04 , C07D491/048
Abstract: An indole derivative represented by formula (1), wherein A is a group or wherein R is hydrogen or lower alkyl, dotted lines may optionally be resent, and R -R represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
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5.发明专利
公开(公告)号：CA2134608C
公开(公告)日：2004-12-07
申请号：CA2134608
申请日：1994-10-28
Applicant: KOWA CO
Inventor： KYOTANI YOSHINORI , KAWAMINE KATSUMI , TOMA TSUTOMU , OHGIYA TADAAKI , YAMAGUCHI TAKASHI , ONOGI KAZUHIRO , SATO SEIICHI , SHIMIZU NOBORU , SHIGYO HIROMICHI , OHTA TOMIO , ODA TOSHIAKI , OKUNO YUKIHIRO , SHIBUYA KIMIYUKI , TAKAHASHI YOSHIO , FUJII MIKIO , UCHIDA YASUMI
IPC: A61K31/40 , C07D491/04 , C07D491/048 , C07F7/10 , A61K31/395 , A61K31/695
Abstract: An indole derivative represented by formula (1), wherein A is a group wherein R10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R1-R9 represents various substitutional groups. The compound. (1) exhibits a positive inotropic action on cardiac muscle, an anti- arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
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公开(公告)号：AT168690T
公开(公告)日：1998-08-15
申请号：AT94117102
申请日：1994-10-28
Applicant: KOWA CO
Inventor： KYOTANI YOSHINORI , KAWAMINE KATSUMI , TOMA TSUTOMU , OHGIYA TADAAKI , YAMAGUCHI TAKASHI , ONOGI KAZUHIRO , SATO SEIICHI , SHIMIZU NOBORU , SHIGYO HIROMICHI , OHTA TOMIO , ODA TOSHIAKI , OKUNO YUKIHIRO , SHIBUYA KIMIYUKI , TAKAHASHI YOSHIO , FUJII MIKIO , UCHIDA YASUMI
IPC: A61K31/40 , C07D491/04 , C07D491/048 , C07D209/00 , C07D307/00
Abstract: An indole derivative represented by formula (1), wherein A is a group or wherein R is hydrogen or lower alkyl, dotted lines may optionally be resent, and R -R represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
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7.发明专利
公开(公告)号：CA2134608A1
公开(公告)日：1995-04-30
申请号：CA2134608
申请日：1994-10-28
Applicant: KOWA CO
Inventor： KYOTANI YOSHINORI , KAWAMINE KATSUMI , TOMA TSUTOMU , OHGIYA TADAAKI , YAMAGUCHI TAKASHI , ONOGI KAZUHIRO , SATO SEIICHI , SHIMIZU NOBORU , SHIGYO HIROMICHI , OHTA TOMIO , ODA TOSHIAKI , OKUNO YUKIHIRO , SHIBUYA KIMIYUKI , TAKAHASHI YOSHIO , FUJII MIKIO , UCHIDA YASUMI
IPC: A61K31/40 , C07D491/04 , C07D491/048 , C07F7/10 , A61K31/395 , A61K31/695
Abstract: An indole derivative represented by formula (1), (1) wherein A is a group O=?-, S=?-, R10N=?-, R10S-?=, or R10OCO-?-, wherein R10 is hydrogen or lower alkyl, dotted lines may optionally be resent, and R1-R9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an antiarrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
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8.发明专利
公开(公告)号：JPH07173162A
公开(公告)日：1995-07-11
申请号：JP25203594
申请日：1994-10-18
Applicant: KOWA CO
Inventor： KYOTANI YOSHINORI , KAWAMINE KATSUMI , TAIMA TSUTOMU , OGIYA TADAAKI , YAMAGUCHI TAKASHI , ONOKI KAZUHIRO , SATO SEIICHI , SHIMIZU NOBORU , SHIGYO HIROMICHI , OTA TOMIO , ODA TOSHIAKI , OKUNO YUKIHIRO , SHIBUYA MASAYUKI , TAKAHASHI YOSHIO , FUJII MIKIO , UCHIDA YASUYOSHI
Abstract: PURPOSE:To obtain a new indole derivative having positively inotropic action on cardiac muscle, antiarrhythmic action and vasodilating action and useful as an agent for the treatment of heart diseases such as cardiac insufficiency and arrhythmia. CONSTITUTION:This indole derivative is expressed by formula I (one of R to R is a lower alkyl or a lower alkenyl and the others each is H or a lower alkyl; R and R each is H, a halogen, etc.; R is H, benzyl, etc.; R and R each is H, OH, etc.; A is group of formula II, III, etc.) or its salt, e.g. 2-(1- imidazolylmethyl)-2,3, 7,8-tetrahydro-5,8,8-trimethyl-6H-furo[2,3-e]indol-7-one. The compound can be produced e.g. by reacting an indole compound of formula IV with an allyl halide of formula V (X is a halogen), heating the obtained compound of formula VI to effect the Claisen rearrangement reaction and reacting the product with a halogenating agent such as N-bromosuccinimide.
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