公开(公告)号：EP0638571A4

公开(公告)日：1995-04-12

申请号：EP93911951

申请日：1993-04-28

Applicant: KOWA CO

Inventor： KYOTANI YOSHINORI ,  OGIYA TADAAKI ,  TOMA TSUTOMU ,  KURIHARA YUJI ,  KITAMURA TAKAHIRO ,  YAMAGUCHI TAKASHI ,  ONOGI KAZUHIRO ,  SATO SEICHI ,  SHIGYO HIROMICHI ,  OTA TOMIO ,  KAWADA MITSUO ,  UCHIDA YASUMI

IPC: C07D491/04 ,  C07D491/048 ,  C07D491/056 ,  A61K31/47

CPC classification number: C07D491/04

Abstract: A quinoline derivative represented by general formula (1), a medicinally acceptable salt thereof, and a remedy for cardiac diseases containing the same, wherein ring A represents a furan, dihydrofuran or dioxolane ring, R1 represents hydroxy, carboxy, alkoxycarbonyl, etc., R2s may be the same or different from each other and each represents hydrogen, alkyl, etc., R?3 and R4¿ may be the same or different from each other and each represents hydrogen, halogen, alkyl, amino, alkoxy, etc., R?5, R6, R7 and R8¿ may be the same or different from one another and each represents hydrogen or alkyl, m represents an integer of 0 to 3, and symbol ...... means that there may be a double bond formed by R?6 and R8¿. The compound (1) has a positively inotropic effect on myocardia and an antiarrhythmic effect and can dilate blood vessels without extremely increasing the heart rate. Therefore, a remedy for cardiac diseases containing the same as the active ingredient is remarkably useful for treating cardiac insufficiency, arrhythmia, and so forth.

Abstract translation: 由通式所表示的喹啉衍生物（1），其药物上可接受的盐，以及用于心脏病含有相同，worin环A darstellt呋喃，二氢呋喃或二氧戊环的补救，R <1> darstellt羟基，羧基，烷氧基羰基， 等，R <2> S可以是相同的或彼此和各darstellt氢，烷基等不同，R <3>和R <4>可以是从彼此，并且每个darstellt氢相同或不同， 卤素，烷基，氨基，烷氧基等，R <5> - [R <6> - [R <7>和R <8>可以相同或彼此不同，分别darstellt氢或烷基，米darstellt成整数 0至3，和符号...... bedeutet，DASS可能存在由R形成双键<6>和R <8>。 的化合物（1）对心肌和抗心律失常效果率的带正性肌力作用和可扩张血管，而不极端地增加的心脏。 因此，对于心脏病含有相同的活性成分的补救可用于治疗心功能不全，心律失常，等等非常有用。

公开(公告)号：EP0190364A4

公开(公告)日：1987-02-12

申请号：EP85904021

申请日：1985-08-12

Applicant: KOWA CO

Inventor： SHIMIZU NOBORU ,  ISHIWATA HIROYUKI ,  OHTA TOMIO ,  ISHIHAMA HIROSHI ,  UCHIDA YASUMI

IPC: C07D401/12 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/455 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D211/90 ,  C07D401/14 ,  A61K31/445

CPC classification number: C07D211/90

Abstract: 1,4-Dihydropyridine-3,5-dicarboxylate derivatives represented by general formula (I) (wherein R represents an imidazolyl group or a pyridyl group, R1 represents a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, R2 represents a lower alkyl group, X represents CH or N, A represents a lower alkylene group, a compound of formula (II) (wherein B represents a lower alkylene group or an O-lower alkylene group), a compound of formula (III) (wherein R4 represents a hydrogen atom or a lower alkyl group) or a compound of formula (IV), m represents a number of 1 to 3, and n represents a number of 1 or 2. They have effects of vasodilation, increasing blood stream, inhibition of platelet coagulation, and inhibition of production of thromboxan A2, and are useful as drugs such as vasodilators, hypotensives, anti-thrombotic drugs, arterial sclerosis-preventing agents, etc.

Abstract translation: 由通式（I）表示的1,4-二氢吡啶-3,5-二羧酸酯衍生物（其中R代表咪唑基或吡啶基，R 1代表氢原子，卤素原子，硝基或三氟甲基，R 2 代表低级烷基，X代表CH或N，A代表低级亚烷基，式（II）化合物（其中B代表低级亚烷基或O-低级亚烷基），式（III）化合物 （其中R 4表示氢原子或低级烷基）或式（IV）化合物，m表示1至3的数，n表示1或2的数。它们具有血管舒张作用，增加血流 ，抑制血小板凝固，抑制血栓素A2的产生，作为血管扩张药，降血压药，抗血栓药，动脉硬化防止药等药物有用。

公开(公告)号：SI0653426T1

公开(公告)日：1998-12-31

申请号：SI9430179

申请日：1994-10-28

Applicant: KOWA CO

Inventor： KYOTANI YOSHINORI ,  KAWAMINE KATSUMI ,  TOMA TSUTOMU ,  OHGIYA TADAAKI ,  YAMAGUCHI TAKASHI ,  ONOGI KAZUHIRO ,  SATO SEIICHI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  OHTA TOMIO ,  ODA TOSHIAKI ,  OKUNO YUKIHIRO ,  SHIBUYA KIMIYUKI ,  TAKAHASHI YOSHIO ,  FUJII MIKIO ,  UCHIDA YASUMI

IPC: A61K31/40 ,  C07D491/04 ,  C07D491/048

Abstract: An indole derivative represented by formula (1), wherein A is a group or wherein R is hydrogen or lower alkyl, dotted lines may optionally be resent, and R -R represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.

公开(公告)号：DE69411852T2

公开(公告)日：1998-12-03

申请号：DE69411852

申请日：1994-10-28

Applicant: KOWA CO

Inventor： KYOTANI YOSHINORI ,  KAWAMINE KATSUMI ,  TOMA TSUTOMU ,  OHGIYA TADAAKI ,  YAMAGUCHI TAKASHI ,  ONOGI KAZUHIRO ,  SATO SEIICHI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  OHTA TOMIO ,  ODA TOSHIAKI ,  OKUNO YUKIHIRO ,  SHIBUYA KIMIYUKI ,  TAKAHASHI YOSHIO ,  FUJII MIKIO ,  UCHIDA YASUMI

IPC: A61K31/40 ,  C07D491/04 ,  C07D491/048

Abstract: An indole derivative represented by formula (1), wherein A is a group or wherein R is hydrogen or lower alkyl, dotted lines may optionally be resent, and R -R represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.

公开(公告)号：DK154557C

公开(公告)日：1989-04-17

申请号：DK264181

申请日：1981-06-16

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI ,  AKASHI TOSHIHIRO ,  NAGAKURA MASAHIKO ,  SAWADA NAOTOSHI ,  UCHIDA YASUMI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66

Abstract: Benzopyrans represented by the formula … … wherein A represents a direct bond or -CH2O-… R1 represents a C3-C5 alkyl group, a hydroxy-(C3-C5 alkyl) group, a lower alkyl-amino-lower alkyl group, a nitrato-(C3-C5 alkyl) group or a phenyl-(C1-C5) alkyl group where the phenyl may be substituted by a lower alkoxy group, R2 represents hydrogen, halogen, OH, NO2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R3 represents hydrogen or NO2, B represents a direct bond, a C1-C7 alkylene group, a -O-lower alkylene group or a -CONH- lower alkylene group, and… n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

公开(公告)号：DK154557B

公开(公告)日：1988-11-28

申请号：DK264181

申请日：1981-06-16

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI ,  AKASHI TOSHIHIRO ,  NAGAKURA MASAHIKO ,  SAWADA NAOTOSHI ,  UCHIDA YASUMI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66

Abstract: Benzopyrans represented by the formula … … wherein A represents a direct bond or -CH2O-… R1 represents a C3-C5 alkyl group, a hydroxy-(C3-C5 alkyl) group, a lower alkyl-amino-lower alkyl group, a nitrato-(C3-C5 alkyl) group or a phenyl-(C1-C5) alkyl group where the phenyl may be substituted by a lower alkoxy group, R2 represents hydrogen, halogen, OH, NO2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R3 represents hydrogen or NO2, B represents a direct bond, a C1-C7 alkylene group, a -O-lower alkylene group or a -CONH- lower alkylene group, and… n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

公开(公告)号：DE3269529D1

公开(公告)日：1986-04-03

申请号：DE3269529

申请日：1982-12-22

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  ISHIHAMA HIROSHI ,  UCHIDA YASUMI

IPC: A61K31/165 ,  A61P9/00 ,  C07C67/00 ,  C07C231/00 ,  C07C235/48 ,  C07C235/60 ,  C07D303/22 ,  C07C103/78

Abstract: Compounds represented by the following formula … … wherein R represents an alkyl group having 2 to 6 carbon atoms and n is an integer of from 1 to 5 have anti-hypertensive, vasodilating, beta -blocking and blood flow increasing activities and are useful as pharmaceuticals.

公开(公告)号：AU543347B2

公开(公告)日：1985-04-18

申请号：AU7165281

申请日：1981-06-11

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  AKASHI TOSHIHIRO ,  NAGUKURA MASAHIKO ,  SAWADA NAOTOSHI ,  UCHIDA YASUMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66 ,  A61K31/35

Abstract: Benzopyrans represented by the formula … … wherein A represents a direct bond or -CH2O-… R1 represents a C3-C5 alkyl group, a hydroxy-(C3-C5 alkyl) group, a lower alkyl-amino-lower alkyl group, a nitrato-(C3-C5 alkyl) group or a phenyl-(C1-C5) alkyl group where the phenyl may be substituted by a lower alkoxy group, R2 represents hydrogen, halogen, OH, NO2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R3 represents hydrogen or NO2, B represents a direct bond, a C1-C7 alkylene group, a -O-lower alkylene group or a -CONH- lower alkylene group, and… n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

公开(公告)号：DE3166300D1

公开(公告)日：1984-10-31

申请号：DE3166300

申请日：1981-06-16

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI ,  AKASHI TOSHIHIRO ,  NAGAKURA MASAHIKO ,  SAWADA NAOTOSHI ,  UCHIDA YASUMI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66 ,  A61K31/35

Abstract: Benzopyrans represented by the formula … … wherein A represents a direct bond or -CH2O-… R1 represents a C3-C5 alkyl group, a hydroxy-(C3-C5 alkyl) group, a lower alkyl-amino-lower alkyl group, a nitrato-(C3-C5 alkyl) group or a phenyl-(C1-C5) alkyl group where the phenyl may be substituted by a lower alkoxy group, R2 represents hydrogen, halogen, OH, NO2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R3 represents hydrogen or NO2, B represents a direct bond, a C1-C7 alkylene group, a -O-lower alkylene group or a -CONH- lower alkylene group, and… n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

公开(公告)号：DE68906427T2

公开(公告)日：1993-10-14

申请号：DE68906427

申请日：1989-02-15

Applicant: KOWA CO

Inventor： TANABE SOHEI ,  SATO SEIICHI ,  KYOTANI YOSHINORI ,  OHTA TOMIO ,  UCHIDA YASUMI

IPC: C07D295/18 ,  A61K31/47 ,  A61K31/472 ,  A61K31/495 ,  A61K31/55 ,  A61P9/00 ,  C07D217/02 ,  C07D243/08 ,  C07D295/192 ,  C07D295/22 ,  C07D295/26

Abstract: A propane derivative represented by the following formula wherein R represents a lower alkyl group; one of A and B represents a group of the formula and the other represents a group of the formula in which R and R are identical or different and each represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, R represents a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group, and X represents a sulfonyl group or a carbonyl group, and an acid addition salt thereof. The compounds provided by this invention have useful biological activities such as the spasmolytic activity on the vascular smooth muscles and anti-platelet aggregatory activity and are useful as drugs for treating cardiovascular diseases such as angina pectoris, cerebral circulation disorder and thrombosis.