公开(公告)号：KR850000193B1

公开(公告)日：1985-03-05

申请号：KR810002196

申请日：1981-06-16

Applicant: KOWA CO

Inventor： SHIRASUTZI NASAMI ,  SHIGYO HIROMICHI ,  KUNIEDA HISASHI ,  SHIMITZ NOBORU ,  KYOTANI YOSHINORI ,  KAWAMURA KIYOSHI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66

公开(公告)号：DK154557C

公开(公告)日：1989-04-17

申请号：DK264181

申请日：1981-06-16

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI ,  AKASHI TOSHIHIRO ,  NAGAKURA MASAHIKO ,  SAWADA NAOTOSHI ,  UCHIDA YASUMI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66

Abstract: Benzopyrans represented by the formula … … wherein A represents a direct bond or -CH2O-… R1 represents a C3-C5 alkyl group, a hydroxy-(C3-C5 alkyl) group, a lower alkyl-amino-lower alkyl group, a nitrato-(C3-C5 alkyl) group or a phenyl-(C1-C5) alkyl group where the phenyl may be substituted by a lower alkoxy group, R2 represents hydrogen, halogen, OH, NO2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R3 represents hydrogen or NO2, B represents a direct bond, a C1-C7 alkylene group, a -O-lower alkylene group or a -CONH- lower alkylene group, and… n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

公开(公告)号：DK154557B

公开(公告)日：1988-11-28

申请号：DK264181

申请日：1981-06-16

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI ,  AKASHI TOSHIHIRO ,  NAGAKURA MASAHIKO ,  SAWADA NAOTOSHI ,  UCHIDA YASUMI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66

Abstract: Benzopyrans represented by the formula … … wherein A represents a direct bond or -CH2O-… R1 represents a C3-C5 alkyl group, a hydroxy-(C3-C5 alkyl) group, a lower alkyl-amino-lower alkyl group, a nitrato-(C3-C5 alkyl) group or a phenyl-(C1-C5) alkyl group where the phenyl may be substituted by a lower alkoxy group, R2 represents hydrogen, halogen, OH, NO2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R3 represents hydrogen or NO2, B represents a direct bond, a C1-C7 alkylene group, a -O-lower alkylene group or a -CONH- lower alkylene group, and… n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

公开(公告)号：AU543347B2

公开(公告)日：1985-04-18

申请号：AU7165281

申请日：1981-06-11

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  AKASHI TOSHIHIRO ,  NAGUKURA MASAHIKO ,  SAWADA NAOTOSHI ,  UCHIDA YASUMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66 ,  A61K31/35

Abstract: Benzopyrans represented by the formula … … wherein A represents a direct bond or -CH2O-… R1 represents a C3-C5 alkyl group, a hydroxy-(C3-C5 alkyl) group, a lower alkyl-amino-lower alkyl group, a nitrato-(C3-C5 alkyl) group or a phenyl-(C1-C5) alkyl group where the phenyl may be substituted by a lower alkoxy group, R2 represents hydrogen, halogen, OH, NO2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R3 represents hydrogen or NO2, B represents a direct bond, a C1-C7 alkylene group, a -O-lower alkylene group or a -CONH- lower alkylene group, and… n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

公开(公告)号：DE3166300D1

公开(公告)日：1984-10-31

申请号：DE3166300

申请日：1981-06-16

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI ,  AKASHI TOSHIHIRO ,  NAGAKURA MASAHIKO ,  SAWADA NAOTOSHI ,  UCHIDA YASUMI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66 ,  A61K31/35

Abstract: Benzopyrans represented by the formula … … wherein A represents a direct bond or -CH2O-… R1 represents a C3-C5 alkyl group, a hydroxy-(C3-C5 alkyl) group, a lower alkyl-amino-lower alkyl group, a nitrato-(C3-C5 alkyl) group or a phenyl-(C1-C5) alkyl group where the phenyl may be substituted by a lower alkoxy group, R2 represents hydrogen, halogen, OH, NO2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R3 represents hydrogen or NO2, B represents a direct bond, a C1-C7 alkylene group, a -O-lower alkylene group or a -CONH- lower alkylene group, and… n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

公开(公告)号：FI79307B

公开(公告)日：1989-08-31

申请号：FI811856

申请日：1981-06-15

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI ,  AKASHI TOSHIHIRO ,  NAGAKURA MASAHIKO ,  SAWADA NAOTOSNI ,  UCHIDA YASUMI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66

Abstract: Benzopyrans represented by the formula … … wherein A represents a direct bond or -CH2O-… R1 represents a C3-C5 alkyl group, a hydroxy-(C3-C5 alkyl) group, a lower alkyl-amino-lower alkyl group, a nitrato-(C3-C5 alkyl) group or a phenyl-(C1-C5) alkyl group where the phenyl may be substituted by a lower alkoxy group, R2 represents hydrogen, halogen, OH, NO2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R3 represents hydrogen or NO2, B represents a direct bond, a C1-C7 alkylene group, a -O-lower alkylene group or a -CONH- lower alkylene group, and… n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

公开(公告)号：CA1157474A

公开(公告)日：1983-11-22

申请号：CA370754

申请日：1981-02-12

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI ,  AKASHI TOSHIHIRO ,  NAGAKURA MASAHIKO ,  SAWADA NAOTOSHI ,  UCHIDA YASUMI

IPC: A61K31/21 ,  A61K31/135 ,  A61K31/165 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61P9/00 ,  A61P9/12 ,  A61P25/02 ,  A61P25/28 ,  C07C67/00 ,  C07C203/04 ,  C07C213/00 ,  C07C217/32 ,  C07C217/70 ,  C07C219/16 ,  C07C219/34 ,  C07C225/16 ,  C07C231/00 ,  C07C231/12 ,  C07C235/42 ,  C07C235/46 ,  C07C237/30 ,  C07C301/00 ,  C07C303/40 ,  C07C311/17 ,  C07C311/29 ,  C07C313/00 ,  C07C315/04 ,  C07C317/22 ,  C07C317/24 ,  C07C317/32 ,  C07C319/20 ,  C07C323/25 ,  C07D213/30 ,  C07D213/60 ,  C07D213/64 ,  C07D213/69 ,  C07D303/24 ,  C07D303/26 ,  C07D309/12 ,  C07C93/14

Abstract: Compounds represented by the following formula (I) wherein A represents a direct bond or the bond -O-CH2-, B represents a C1-C11 alkylene group bonded to a carbon atom of the aromatic ring D either directly or through -O-, -S, -SO- or -NH-, W represents a carbon or nitrogen atom, R1 represents a C3-C7 alkyl group, a hydroxy-C1-C6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms, R2 represents a member selected from the group consisting of hydrogen, halogen, OH, C1-C4 alkyl, NO2, C1-C4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R2 groups exist, they may be identical or different, and n represents 1, 2 or 3 and m represents 1 or 2, provided that n + m ? 4; and acid addition salts thereof are disclosed as well as processes for producing them and pharmaceutical compositions containing the aforesaid compounds. The compounds (I) exhibit muscle relaxing and adrenergic blocking action, as well as myocardial oxygen consumption lowering action and blood pressure lowering action.

公开(公告)号：DD160453A5

公开(公告)日：1983-08-03

申请号：DD23089481

申请日：1981-06-17

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  SHIMIZU NOBORU ,  SHIGYO HIROMICHI ,  KYOTANI YOSHINORI ,  KUNIEDA HISASHI ,  KAWAMURA KIYOSHI ,  SATO SEIICHI ,  AKASHI TOSHIHIRO ,  NAGAKURA MASHIKO ,  SAWADA NAOTOSHI ,  UCHIDA YASUMI

IPC: C07D311/04 ,  A61K31/353 ,  A61P9/02 ,  A61P9/04 ,  A61P21/02 ,  C07D311/22 ,  C07D311/58 ,  C07D311/64 ,  C07D311/66

Abstract: Benzopyrans represented by the formula … … wherein A represents a direct bond or -CH2O-… R1 represents a C3-C5 alkyl group, a hydroxy-(C3-C5 alkyl) group, a lower alkyl-amino-lower alkyl group, a nitrato-(C3-C5 alkyl) group or a phenyl-(C1-C5) alkyl group where the phenyl may be substituted by a lower alkoxy group, R2 represents hydrogen, halogen, OH, NO2, a carbamoyl group, a lower alkyl group, a lower alkoxy group, a lower alkyleneoxy group or an acetyl group, R3 represents hydrogen or NO2, B represents a direct bond, a C1-C7 alkylene group, a -O-lower alkylene group or a -CONH- lower alkylene group, and… n represents 1 or 2; and their acid addition salts are useful, for example, in reducing heart beat rate, myocardial oxygen consumption and blood pressure.

公开(公告)号：DE2821704A1

公开(公告)日：1978-11-23

申请号：DE2821704

申请日：1978-05-18

Applicant: KOWA CO

Inventor： SHIRATSUCHI MASAMI ,  KAWAMURA KIYOSHI ,  KUNIEDA HISASHI ,  MACHIDA NAOKI ,  AKASHI TOSHIHIRO ,  NAGAKURA MASAHIKO

IPC: A61K31/195 ,  A61K31/16 ,  A61K31/22 ,  A61P1/04 ,  C07C67/00 ,  C07C325/00 ,  C07C381/12 ,  C07D213/82 ,  C07C149/46 ,  A61K31/095

Abstract: Methylmethioninesulfonium compounds of the formula wherein X(-) represents an anion; R1 represents a hydrogen atom or an acyl group of the formula -COR3 in which R3 represents an alkyl group with 1 to 20 carbon atoms, the group -CH2)2 COOH or the group in which Z represents a direct bond or a methylene or vinylene linkage, Y represents C or N, R4 represents a member selected from the class consisting of a hydrogen atom, lower alkyl groups, lower alkoxy groups, di-lower-alkylamino groups and a sulfamoyl group, n is a number of 1 to 3, and two or more R4 groups may be identical or different; and R2 represents the group -COOR5 in which R5 represents a hydrogen atom, an alkyl group with 1 to 5 carbon atoms or a metal- or metal complex-forming moiety, or the group in which R6 groups may be identical or different, and each represent a hydrogen atom or an alkyl group with 1 to 5 carbon atoms, with the proviso that when R1 represents a hydrogen atom, R2 is not -COOH; when R1 represents a hydrogen atom and R2 represents -CONH2, X(-) is not Cl(-); and when R1 is -COCH3 and R2 is -COOCH3, X(-) is not I(-). The compounds can be easily prepared from methionine as a starting material by a combination of known unit reactions such as methylsulfonium-forming reaction, acylation, amidation, esterification and metal salt-forming reaction. These compounds are especially useful for treating ulcers.

公开(公告)号：CA1233467A

公开(公告)日：1988-03-01

申请号：CA455247

申请日：1984-05-28

Applicant: KOWA CO

Inventor： FUJII SETSURO ,  HATTORI EIZOU ,  HIRATA MITSUTERU ,  KUNIEDA HISASHI ,  WATANABE KOICHIRO ,  ISHIHAMA HIROSHI

IPC: C07D295/10 ,  A61K31/495 ,  A61P1/00 ,  A61P43/00 ,  C07D295/108 ,  C07D295/12 ,  C07D295/13 ,  C07D295/18 ,  C07D295/185 ,  C07D295/14

Abstract: Phenyl tetrahydronaphthylcarboxylate derivatives of the formula: wherein A is a direct bond, or a lower alkylene, vinylene or imino group; B is a direct bond, a lower alkylene or -NH-lower alkylene group, or an -OCH2CO- residual group; and R is a lower alkyl group, with the proviso that A and B are not direct bonds simultaneously, and A, B and R are not a lower alkylene group, a direct bond and a methyl group, respectively, at the same time, are effectively useful as chymotrypsin inhibitors.