公开(公告)号：WO2007018327A1

公开(公告)日：2007-02-15

申请号：PCT/KR2005/003037

申请日：2005-09-14

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  AHN, Yeong Hee ,  KWON, Kyung-Hoon ,  YOO, Jong Shin

Inventor： AHN, Yeong Hee ,  KWON, Kyung-Hoon ,  YOO, Jong Shin

IPC: G01N33/68

CPC classification number: C07K14/4732

Abstract: The present invention relates to a method for analyzing modified polypeptide sequence and modified information thereof. More precisely, the invention relates to a method for identifying modified peptide in which fragment ion signals are obtained from target peptide precursor by using tandem mass spectrometry, candidate peptides and every possible peptide fragmentation patterns thereof are designed based on the mass data thereby, match scores corresponding to each fragmentation pattern of candidate peptides are given, and then by combining each matching scores derived from possible fragmentation patterns of a candidate peptide, modified target polypeptide is identified by tandem mass data based on the provided match score. The scoring method for modified polypeptide of the present invention can greatly contribute to increasing searching efficiency of modified peptides and reliability of the searching results by integrating all scored values obtained from different fragmentation patterns of a candidate peptide.

Abstract translation: 本发明涉及一种分析修饰多肽序列的方法及其修饰信息。 更准确地说，本发明涉及一种用于鉴定通过使用串联质谱法从靶肽前体获得片段离子信号的修饰肽的方法，并且基于质量数据设计候选肽和其每种可能的肽断裂模式，从而匹配得分 对应于候选肽的每个断裂模式，然后通过组合从候选肽的可能的断裂模式导出的每个匹配分数，基于所提供的匹配分数，通过串联质量数据鉴定修饰的目标多肽。 本发明的修饰多肽的评分方法可以通过整合从候选肽的不同片段化模式获得的所有得分值，大大有助于提高修饰肽的搜索效率和搜索结果的可靠性。

公开(公告)号：WO2010018882A1

公开(公告)日：2010-02-18

申请号：PCT/KR2008/004735

申请日：2008-08-14

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  KWON, Kyung-Hoon ,  PARK, Gun Wook ,  LEE, Jeong Hwa ,  YOO, Jong Shin

Inventor： KWON, Kyung-Hoon ,  PARK, Gun Wook ,  LEE, Jeong Hwa ,  YOO, Jong Shin

IPC: G06F17/30 ,  C12Q1/68

CPC classification number: G06F19/28 ,  G06F19/20 ,  G06F19/26

Abstract: The present invention relates to an apparatus for visualizing or analyzing gene expression patterns of a biological sample using gene ontology tree and a method of the same, more precisely, an apparatus for visualizing or analyzing gene expression patterns which are regarded as biologically important using gene ontology tree by calculating complexity and a method of the same. This apparatus of the present invention is useful for comparing gene expression patterns in different biological samples using data produced by the said apparatus and the method of the present invention. According to the present invention, gene expression patterns in relation to molecular functions, biological processes or cellular components can be analyzed by investigating protein or RNA expression in biological samples. So, the apparatus and the method of the present invention can be effectively used for analysis of biologically important aspects such as functional changes, evolutionary stages or developmental stages of each biological sample.

Abstract translation: 本发明涉及使用基因本体树来观察或分析生物样品的基因表达模式的装置及其方法，更确切地说，涉及用于使用基因本体论被视为生物学重要性的基因表达模式进行可视化或分析的装置 树的计算复杂度和方法相同。 本发明的该装置可用于使用由所述装置产生的数据和本发明的方法来比较不同生物样品中的基因表达模式。 根据本发明，可以通过研究生物样品中的蛋白质或RNA表达来分析与分子功能，生物过程或细胞成分有关的基因表达模式。 因此，本发明的装置和方法可以有效地用于生物学重要方面的分析，例如每个生物样品的功能变化，进化阶段或发育阶段。

公开(公告)号：WO2008102922A1

公开(公告)日：2008-08-28

申请号：PCT/KR2007/000946

申请日：2007-02-23

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  PARK, Gun Wook ,  KWON, Kyung-Hoon ,  KIM, Jin Young ,  YOO, Jong Shin ,  PARK, Young Mok ,  KIM, Seung Il

Inventor： PARK, Gun Wook ,  KWON, Kyung-Hoon ,  KIM, Jin Young ,  YOO, Jong Shin ,  PARK, Young Mok ,  KIM, Seung Il

IPC: G06F19/00

CPC classification number: G01N33/6848 ,  H01J49/004

Abstract: The present invention relates to a method of analyzing protein modification. The method of invention for analyzing protein distribution and characteristics on one-dimensional gel provides the way to analyze proteins of samples on one-dimensional gel quantitatively and provides information on interactions among proteins and further can be effectively used for the development of a novel diagnostic and therapeutic method for a disease by screening a disease marker protein.

Abstract translation: 本发明涉及分析蛋白质修饰的方法。 本发明用于分析一维凝胶上的蛋白质分布和特征的方法提供了定量分析一维凝胶上样品蛋白质的方法，提供蛋白质间相互作用信息，进一步有效地用于开发新型诊断和 通过筛选疾病标记蛋白来治疗疾病的治疗方法。

公开(公告)号：WO2008007821A1

公开(公告)日：2008-01-17

申请号：PCT/KR2006/003261

申请日：2006-08-18

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  KWON, Kyung-Hoon ,  YOO, Jong Shin

Inventor： KWON, Kyung-Hoon ,  YOO, Jong Shin

IPC: G06F17/30

CPC classification number: G06F19/28 ,  G06F19/18 ,  G06F19/22

Abstract: The present invention relates to a method for reconstructing protein database for identifying a protein and a method for screening a protein using the same, more precisely a method for reconstructing protein database comprising the steps of i) Grouping proteins having a required homology by using the clustering software from the primary database which minimizes the overlapping of proteins and then recording sequence information of each protein group on a recording system of a computer; and ii) Designating a representative protein in each protein group and then constructing the representative protein database composed of the representative proteins, followed by recording the results containing sequence information on a recording system of a computer, and a method for identifying a protein using the same. The method for reconstructing protein database and the method for identifying the protein of the invention are very useful for the investigation of endogenous proteins and their functions and interactions, and are further effectively used for the development of diagnostic and therapeutic agents for various diseases.

Abstract translation: 本发明涉及一种用于重建用于鉴定蛋白质的蛋白质数据库的方法和使用该蛋白质筛选蛋白质的方法，更准确地说，一种重建蛋白质数据库的方法，包括以下步骤：i）通过使用聚类分组具有所需同源性的蛋白质 来自主数据库的软件，其最小化蛋白质的重叠，然后在计算机的记录系统上记录每个蛋白质组的序列信息; 和ii）指定每个蛋白质组中的代表性蛋白质，然后构建由代表性蛋白质组成的代表性蛋白质数据库，然后将含有序列信息的结果记录在计算机的记录系统上，以及用于鉴定使用其的蛋白质的方法 。 重组蛋白质数据库的方法和鉴定本发明蛋白质的方法对于内源蛋白质及其功能和相互作用的研究非常有用，并且进一步有效地用于各种疾病的诊断和治疗剂的开发。

公开(公告)号：EP1946119B1

公开(公告)日：2010-10-27

申请号：EP05808964.0

申请日：2005-09-14

Applicant: Korea Basic Science Institute

Inventor： AHN, Yeong Hee ,  KWON, Kyung-Hoon ,  YOO, Jong Shin

IPC: G01N33/68

CPC classification number: C07K14/4732

Abstract: The present invention relates to a method for analyzing modified polypeptide sequence and modified information thereof. More precisely, the invention relates to a method for identifying modified peptide in which fragment ion signals are obtained from target peptide precursor by using tandem mass spectrometry, candidate peptides and every possible peptide fragmentation patterns thereof are designed based on the mass data thereby, match scores corresponding to each fragmentation pattern of candidate peptides are given, and then by combining each matching scores derived from possible fragmentation patterns of a candidate peptide, modified target polypeptide is identified by tandem mass data based on the provided match score. The scoring method for modified polypeptide of the present invention can greatly contribute to increasing searching efficiency of modified peptides and reliability of the searching results by integrating all scored values obtained from different fragmentation patterns of a candidate peptide.

公开(公告)号：EP1946119A1

公开(公告)日：2008-07-23

申请号：EP05808964.0

申请日：2005-09-14

Applicant: Korea Basic Science Institute

Inventor： AHN, Yeong Hee ,  KWON, Kyung-Hoon ,  YOO, Jong Shin

IPC: G01N33/68

CPC classification number: C07K14/4732

Abstract: The present invention relates to a method for analyzing modified polypeptide sequence and modified information thereof. More precisely, the invention relates to a method for identifying modified peptide in which fragment ion signals are obtained from target peptide precursor by using tandem mass spectrometry, candidate peptides and every possible peptide fragmentation patterns thereof are designed based on the mass data thereby, match scores corresponding to each fragmentation pattern of candidate peptides are given, and then by combining each matching scores derived from possible fragmentation patterns of a candidate peptide, modified target polypeptide is identified by tandem mass data based on the provided match score. The scoring method for modified polypeptide of the present invention can greatly contribute to increasing searching efficiency of modified peptides and reliability of the searching results by integrating all scored values obtained from different fragmentation patterns of a candidate peptide.