公开(公告)号：WO2010018882A1

公开(公告)日：2010-02-18

申请号：PCT/KR2008/004735

申请日：2008-08-14

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  KWON, Kyung-Hoon ,  PARK, Gun Wook ,  LEE, Jeong Hwa ,  YOO, Jong Shin

Inventor： KWON, Kyung-Hoon ,  PARK, Gun Wook ,  LEE, Jeong Hwa ,  YOO, Jong Shin

IPC: G06F17/30 ,  C12Q1/68

CPC classification number: G06F19/28 ,  G06F19/20 ,  G06F19/26

Abstract: The present invention relates to an apparatus for visualizing or analyzing gene expression patterns of a biological sample using gene ontology tree and a method of the same, more precisely, an apparatus for visualizing or analyzing gene expression patterns which are regarded as biologically important using gene ontology tree by calculating complexity and a method of the same. This apparatus of the present invention is useful for comparing gene expression patterns in different biological samples using data produced by the said apparatus and the method of the present invention. According to the present invention, gene expression patterns in relation to molecular functions, biological processes or cellular components can be analyzed by investigating protein or RNA expression in biological samples. So, the apparatus and the method of the present invention can be effectively used for analysis of biologically important aspects such as functional changes, evolutionary stages or developmental stages of each biological sample.

Abstract translation: 本发明涉及使用基因本体树来观察或分析生物样品的基因表达模式的装置及其方法，更确切地说，涉及用于使用基因本体论被视为生物学重要性的基因表达模式进行可视化或分析的装置 树的计算复杂度和方法相同。 本发明的该装置可用于使用由所述装置产生的数据和本发明的方法来比较不同生物样品中的基因表达模式。 根据本发明，可以通过研究生物样品中的蛋白质或RNA表达来分析与分子功能，生物过程或细胞成分有关的基因表达模式。 因此，本发明的装置和方法可以有效地用于生物学重要方面的分析，例如每个生物样品的功能变化，进化阶段或发育阶段。

公开(公告)号：WO2008102922A1

公开(公告)日：2008-08-28

申请号：PCT/KR2007/000946

申请日：2007-02-23

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  PARK, Gun Wook ,  KWON, Kyung-Hoon ,  KIM, Jin Young ,  YOO, Jong Shin ,  PARK, Young Mok ,  KIM, Seung Il

Inventor： PARK, Gun Wook ,  KWON, Kyung-Hoon ,  KIM, Jin Young ,  YOO, Jong Shin ,  PARK, Young Mok ,  KIM, Seung Il

IPC: G06F19/00

CPC classification number: G01N33/6848 ,  H01J49/004

Abstract: The present invention relates to a method of analyzing protein modification. The method of invention for analyzing protein distribution and characteristics on one-dimensional gel provides the way to analyze proteins of samples on one-dimensional gel quantitatively and provides information on interactions among proteins and further can be effectively used for the development of a novel diagnostic and therapeutic method for a disease by screening a disease marker protein.

Abstract translation: 本发明涉及分析蛋白质修饰的方法。 本发明用于分析一维凝胶上的蛋白质分布和特征的方法提供了定量分析一维凝胶上样品蛋白质的方法，提供蛋白质间相互作用信息，进一步有效地用于开发新型诊断和 通过筛选疾病标记蛋白来治疗疾病的治疗方法。

公开(公告)号：EP2738554B1

公开(公告)日：2015-09-30

申请号：EP13814404.3

申请日：2013-01-22

Applicant: Korea Basic Science Institute

Inventor： PARK, Gun Wook ,  YOO, Jong Shin ,  KIM, Jin Young ,  LEE, Ju Yeon ,  LEE, Hyun Kyoung ,  AN, Hyun Joo ,  KIM, Jae-Han

IPC: G01N30/72 ,  G01N33/68 ,  C12Q1/34 ,  G06F17/10 ,  G06F19/00

CPC classification number: G06F19/16 ,  C12Q1/37 ,  G01N30/86 ,  G01N33/6848 ,  G01N2030/8813 ,  G01N2030/8831 ,  G01N2400/00 ,  G01N2440/38 ,  G01N2560/00 ,  G01N2570/00 ,  H01J49/0027 ,  H01J49/0036 ,  H01J49/004

公开(公告)号：EP2738554A1

公开(公告)日：2014-06-04

申请号：EP13814404.3

申请日：2013-01-22

Applicant: Korea Basic Science Institute

Inventor： PARK, Gun Wook ,  YOO, Jong Shin ,  KIM, Jin Young ,  LEE, Ju Yeon ,  LEE, Hyun Kyoung ,  AN, Hyun Joo ,  KIM, Jae-Han

IPC: G01N30/72 ,  G01N33/68 ,  C12Q1/34 ,  G06F17/10

CPC classification number: G06F19/16 ,  C12Q1/37 ,  G01N30/86 ,  G01N33/6848 ,  G01N2030/8813 ,  G01N2030/8831 ,  G01N2400/00 ,  G01N2440/38 ,  G01N2560/00 ,  G01N2570/00 ,  H01J49/0027 ,  H01J49/0036 ,  H01J49/004

Abstract: The present invention relates to a more efficient and accurate method for the identification and quantification of comparatively low abundant glycopeptides, compared with general peptides, using mass spectrum obtained by using high resolution mass spectrometer. Therefore, the method of the present invention can be effectively used for the techniques for identification of biotherapeutics and diagnosis of cancer or disease by screening glycopeptide, the disease marker (Biomarker), from various samples.

Abstract translation: 本发明涉及使用通过使用高分辨率质谱仪获得的质谱，与一般肽相比，用于鉴定和定量相对低丰度糖肽的更有效和准确的方法。 因此，通过从各种样品中筛选糖肽（疾病标记物（Biomarker）），本发明的方法可以有效地用于识别生物治疗剂和癌症或疾病的诊断技术。