公开(公告)号：EP4467133A1

公开(公告)日：2024-11-27

申请号：EP23743538.3

申请日：2023-01-20

Applicant: Korea Institute of Science and Technology

Inventor： YANG, Yoosoo ,  KIM, Sun Hwa ,  HAN, Geonhee ,  JANG, Yeongji ,  KIM, Hyosuk ,  CHO, Haeun

IPC: A61K9/50 ,  A61K31/713 ,  A61K31/711 ,  A61K31/7105 ,  A61K9/19 ,  A61P1/00 ,  A61K35/20 ,  A61P29/00

Abstract: The present invention relates to a composition for improving intestinal health and function comprising: a milk-derived exosomes; and a therapeutic agent, wherein the therapeutic agent is DNA, RNA, or a small molecule, and the therapeutic agent is positioned and encapsulated in spaces inside the exosomes. In addition, provided is a method for manufacturing a composition for improving intestinal health and function, the method comprising the steps of: (a) isolating exosomes from milk; (b) forming micropores on the surfaces of the exosomes by subjecting the separated exosomes to electroporation; (c) mixing the exosomes that have undergone electroporation in step (b) with a therapeutic agent; and (d) removing therapeutic agent which has not been encapsulated inside the exosomes.