公开(公告)号：EP2431378A2

公开(公告)日：2012-03-21

申请号：EP10775037.4

申请日：2010-03-02

Applicant: Korea Institute of Science and Technology

Inventor： KIM, Kwang Meyung ,  KWON, Ick Chan ,  CHOI, Kui Won ,  LEE, Seung Young ,  YOUN, In Chan ,  HUH, Myung Sook ,  LEE, So Jin

IPC: C07H21/00 ,  C12N15/87

CPC classification number: C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/51 ,  C12N2320/32 ,  C12N2320/51

Abstract: The present invention relates to a high-molecular weight oligonucleotides polymerization method which increases in vivo stability, and to the use of a high-molecular weight oligonucleotides prepared by the polymerization method.
The oligonucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular weight oligonucleotides. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.

Abstract translation: 本发明涉及一种增加在体内的稳定性，并涉及使用通过聚合方法制备的高分子量的寡核苷酸的高分子量的寡核苷酸的聚合方法。 在寡核苷酸具有小分子量可容易地聚合成高分子量的寡核苷酸做了本发明的寡核苷酸的聚合方法是有利的。 此外，通过本发明的方法制备的高分子的寡核苷酸能结合到亲水性高分子材料或无机材料，然后可以稳定地输送到活体。 因此，通过本发明的方法制备的高分子的寡核苷酸，可广泛用于治疗各种疾病。