公开(公告)号：EP3560927A1

公开(公告)日：2019-10-30

申请号：EP17811428.6

申请日：2017-11-06

Applicant: Korea Institute of Science and Technology

Inventor： CHOO, Hyunah ,  KIM, Youngjae ,  SEONG, Jihye ,  NAM, Ghil Soo ,  CHO, Yong Seo

IPC: C07D487/04 ,  A61K31/55

Abstract: Azepine derivatives acting on 5-HT 7 receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HT 7 receptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HT 7 receptors antagonistic activity is required.