公开(公告)号：WO1997011354A1

公开(公告)日：1997-03-27

申请号：PCT/FI1996000498

申请日：1996-09-20

Applicant: LABSYSTEMS OY ,  TUUNANEN, Jukka ,  KÄRMENIEMI, Timo

Inventor： LABSYSTEMS OY

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/0224

Abstract: The invention relates to a fluorometer having a partly transparent mirror (27) through which excitation light is directed to the sample and via which emitted light from the sample is reflected. Thus a high sensitivity and, furthermore, as homogenous a measurement sensitivity distribution as possible within the vessel are achieved. Measuring can be carried out from either above or below. The invention is applicable for use especially when the fluorometer has simultaneously a plurality of samples.

Abstract translation: 本发明涉及一种具有部分透明的反射镜（27）的荧光计，激发光通过该反射镜被引导到样品，通过该荧光计反射来自样品的发射光。 因此，实现了高灵敏度，此外，实现了容器内尽可能均匀的测量灵敏度分布。 测量可以从上方或下方进行。 本发明特别适用于当荧光计同时具有多个样品时。

公开(公告)号：WO1997011352A1

公开(公告)日：1997-03-27

申请号：PCT/FI1996000499

申请日：1996-09-20

Applicant: LABSYSTEMS OY ,  PRIHA, Matti ,  TUPAKKA, Heikki

Inventor： LABSYSTEMS OY

IPC: G01N21/01

CPC classification number: B01L9/523 ,  B01L2300/0829 ,  G01N35/028 ,  G01N2035/042 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998

Abstract: The invention relates to a holder in which sample-holding plates can be handled. It has a retainer (49) for pressing a plate placed in the holder both against the back wall and against a side wall. Thus a plate of a certain type will always settle in the same position in the holder. It is also possible to use in the holder plates of many sizes, which can be kept in place during handling owing to the retainer. The invention is suitable for use in particular in assay methods in which samples to be assayed are handled on plates comprising a plurality of wells, for example in optical analysers or other apparatuses.

Abstract translation: 本发明涉及可以处理样品保持板的保持器。 其具有用于将放置在保持器中的板压靠在后壁上并抵靠侧壁的保持器（49）。 因此，某种类型的板材将始终处于保持器中相同的位置。 也可以在许多尺寸的保持板中使用，其可以由于保持器而在处理期间保持在适当位置。 本发明特别适用于测定方法，其中待测定的样品在包括多个孔的板上处理，例如在光学分析仪或其他装置中。

公开(公告)号：WO1994018565A1

公开(公告)日：1994-08-18

申请号：PCT/FI1994000048

申请日：1994-02-01

Applicant: LABSYSTEMS OY ,  TUUNANEN, Jukka

Inventor： LABSYSTEMS OY

IPC: G01N33/543

CPC classification number: B03C1/286 ,  B01L3/02 ,  B01L3/50853 ,  B01L2200/0657 ,  B01L2300/044 ,  B01L2300/0829 ,  B01L2300/0848 ,  B01L2300/16 ,  B03C2201/18 ,  G01N33/54326 ,  G01N33/54366 ,  G01N35/0098 ,  G01N35/026 ,  G01N35/1065 ,  G01N35/109 ,  G01N2035/1055 ,  Y10S436/806 ,  Y10S436/808 ,  Y10T436/25375

Abstract: The invention concerns a determination method and equipment and an adapter for use in these. In the method, the sample is allowed to react with a separating reagent bound in a solid phase to the outer surface of particles (8) which are separated from the vessel, whereafter the particles are removed from the vessel using a remover (3.2) and they are taken to a measuring vessel, if required through one or several intermediate step vessels. At least one vessel contains a medium needed in a determination step to be performed therein when the particles are brought into this vessel. The invention is especially suitable for use in automatic immunodetermination systems.

Abstract translation: 本发明涉及用于这些的确定方法和设备以及适配器。 在该方法中，允许样品与固相结合的分离试剂与从容器分离的颗粒（8）的外表面反应，然后使用去除剂（3.2）将颗粒从容器中取出， 如果需要，它们被带到测量容器中，通过一个或多个中间步骤容器。 当颗粒进入该容器时，至少一个容器含有在其中进行的确定步骤中所需的介质。 本发明特别适用于自动免疫测定系统。

公开(公告)号：WO1988006138A1

公开(公告)日：1988-08-25

申请号：PCT/FI1988000024

申请日：1988-02-17

Applicant: LABSYSTEMS OY ,  TERVAMÄKI, Jukka ,  HEINONEN, Mauno ,  PRIHA, Matti ,  KOIVISTO, Juha

Inventor： LABSYSTEMS OY

IPC: B67D05/40

CPC classification number: B67D7/66 ,  F04B43/1215 ,  G01F11/125 ,  Y10S128/12

Abstract: Dosage equipment, which includes a peristaltic pump for the dosage of liquid. The set of hoses (17) of the peristaltic pump includes an upper piece (18) and a lower piece (19). The body of the pump includes an attaching piece (13), to which the upper piece and the lower piece can be attached.

Abstract translation: 剂量设备，包括用于液体剂量的蠕动泵。 蠕动泵的一组软管（17）包括上部件（18）和下部件（19）。 泵的主体包括安装件（13），上部件和下部件可以安装在该附接件上。

公开(公告)号：WO1987002138A1

公开(公告)日：1987-04-09

申请号：PCT/FI1986000111

申请日：1986-10-07

Applicant: LABSYSTEMS OY ,  PARTANEN, Paul ,  SEPPÄNEN, Helena ,  HARJUNMAA, Hannu

Inventor： LABSYSTEMS OY

IPC: G01N35/00

CPC classification number: G01N35/1083 ,  G01N35/109 ,  Y10S435/809

Abstract: An immunological assay system, wherein the inner face of the cuvettes is used as the solid phase. The equipment includes a displaceable carriage (8) for the cuvette set as well as, above the carriage, a dosage head (9), to which the liquid dosimeter (11) and the measurement device (19) are attached. All the operations take place automatically.

Abstract translation: 免疫测定系统，其中将比色杯的内表面用作固相。 该设备包括用于比色皿组的可移动托架（8）以及托架上方的剂量头（9），液体剂量计（11）和测量装置（19）附接到该剂量头。 所有操作都会自动进行。

公开(公告)号：WO1982000360A1

公开(公告)日：1982-02-04

申请号：PCT/FI1981000058

申请日：1981-07-24

Applicant: LABSYSTEMS OY

Inventor： LABSYSTEMS OY ,  PARTANEN P ,  SUOVANIEMI O ,  KAUKANEN E ,  EKHOLM P ,  JAERNEFELT J

IPC: G01N21/07

CPC classification number: G01N21/07 ,  G01N21/253

Abstract: Method for the measurement of properties of a liquid present in a vessel (2), for example for the measurement of the absorbance of a liquid, of the properties of an agglutination, precipitate (4) or any other reaction result placed on the bottom of a vessel, by means of radiation and of a detector (3) receiving radiation while the vessel moves along with a rotor revolving around the vertical axis (15) of a centrifuge. Thereby the beam of measurement (5) coming from the source of radiation (1) passes substantially horizontally and the intensity of the radiation passing through, or reflected from, the contents of the vessel is measured. According to the invention, for the purpose of the measurement of the properties of the liquid, after the vessel (2) has pivoted for the measurement by the effect of centrifugal force so that its longitudinal axis is positioned substantially horizontally, a field of limited area is measured out of the bottom of the vessel (2) while the vessel (2) moves along with the rotor of the centrifuge through the space between the source of radiation (1) and the detector (3). The measurement result of the component field at each particular time under measurement is read constantly or at specified intervals for the purpose of processing and output of the information.

Abstract translation: 用于测量容器（2）中存在的液体的性质的方法，例如用于测量液体的吸光度，凝集性质，沉淀物（4）或任何其他反应结果放置在底部 容器通过辐射和检测器（3）接收辐射，同时血管与围绕离心机的垂直轴线（15）旋转的转子一起移动。 因此，来自辐射源（1）的测量光束（5）基本上水平地通过，并且测量通过或反射的容器的内容物的强度。 根据本发明，为了测量液体的性质，在容器（2）通过离心力的作用使枢轴转动以使其纵向轴线基本上水平地定位之后，限制区域 在容器（2）与离心机的转子一起移动通过辐射源（1）和检测器（3）之间的空间的同时，从容器（2）的底部测出。 为了处理和输出信息，测量时每个特定时间的分量场的测量结果是不断读取的或以指定的间隔读取的。

公开(公告)号：WO1996012961A1

公开(公告)日：1996-05-02

申请号：PCT/FI1995000580

申请日：1995-10-20

Applicant: LABSYSTEMS OY ,  KORPELA, Matti ,  TUUNANEN, Jukka

Inventor： LABSYSTEMS OY

IPC: G01N33/543

CPC classification number: B03C1/284 ,  G01N33/54326

Abstract: The invention relates to a two-stage method for separating magnetic particles from a composition containing them. In the method, a separating member is introduced into the composition, the member comprising a separating surface, the particles are pulled from the composition, by using a magnetic field, to be adhered to a separating surface, the effect of the magnetic field is eliminated, and the particles (16) are collected thereafter from the separating surface. In this way, it is possible to collect particles effectively even from a large volume. It is also easy to transfer particles into a small volume. The invention can be employed in various applications, especially in the fields of biotechnology, biochemistry, and biomedicine.

Abstract translation: 本发明涉及从含有它们的组合物中分离磁性颗粒的两阶段方法。 在该方法中，将分离构件引入组合物中，该构件包括分离表面，通过使用磁场从组合物中拉出颗粒以粘附到分离表面，消除磁场的影响 ，然后从分离表面收集颗粒（16）。 以这种方式，即使从大体积上也能有效地收集颗粒。 将颗粒转移到小体积中也是容易的。 本发明可用于各种应用，特别是在生物技术，生物化学和生物医学领域。

公开(公告)号：WO1996012958A1

公开(公告)日：1996-05-02

申请号：PCT/FI1995000577

申请日：1995-10-20

Applicant: LABSYSTEMS OY ,  TUUNANEN, Jukka

Inventor： LABSYSTEMS OY

IPC: G01N33/543

CPC classification number: G01N33/54326 ,  B03C1/284 ,  Y10S436/805 ,  Y10S436/806 ,  Y10T436/25375

Abstract: The invention relates to a means for separating magnetic particles from a composition. The means comprises an elongated protective cover (1) that comprises a recess (2) extending from the upper end towards the lower end thereof, the recess comprising a movable magnetic rod (4), the proportion of the length of the rod to its thickness being at least about 2:1. The invention can be used in different applications especially in the fields of biotechnology, biochemistry, and biomedicine. Collecting particles by using the means is easy and fast.

Abstract translation: 本发明涉及一种从组合物中分离磁性颗粒的方法。 该装置包括细长的保护罩（1），其包括从其上端向下端延伸的凹部（2），所述凹部包括可动磁棒（4），所述杆的长度与其厚度的比例 至少约2：1。 本发明可用于不同的应用，特别是在生物技术，生物化学和生物医学领域。 通过使用手段收集颗粒是容易和快速的。

公开(公告)号：WO1994018564A1

公开(公告)日：1994-08-18

申请号：PCT/FI1994000047

申请日：1994-02-01

Applicant: LABSYSTEMS OY ,  TUUNANEN, Jukka

Inventor： LABSYSTEMS OY

IPC: G01N33/543

CPC classification number: B01L3/02 ,  B01L3/50853 ,  B01L2300/044 ,  B01L2300/0829 ,  B01L2300/0848 ,  B01L2300/16 ,  G01N33/54366 ,  G01N35/0098 ,  G01N35/026 ,  G01N2035/1055 ,  Y10S435/962 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/824

Abstract: The invention concerns a solid-phase determination method and equipment and an adapter for use in these. In the method a sample is allowed to react with a separating reagent bound to the outer surface of a separate solid-phase body (4), whereafter the body is removed from the vessel and is taken to a measuring vessel, if required through one or several intermediate step vessels. At least one vessel contains a medium needed in a determination step to be performed therein when the phase body is brought into this vessel. The invention is especially suitable for use in automatic immunodetermination systems.

Abstract translation: 本发明涉及用于这些的固相测定方法和设备以及适配器。 在该方法中，允许样品与结合到单独固相体（4）的外表面的分离试剂反应，然后将主体从容器中取出，并将其带入测量容器，如果需要，通过一个或多个 几个中间步骤船。 至少一个容器包含当相体进入该容器时在其中执行的确定步骤中所需的介质。 本发明特别适用于自动免疫测定系统。

公开(公告)号：WO1986006493A1

公开(公告)日：1986-11-06

申请号：PCT/FI1986000041

申请日：1986-04-29

Applicant: LABSYSTEMS OY ,  LUOTOLA, Juhani ,  TIUSANEN, Tapani ,  SAVONLAHTI, Jukka ,  HARJUNMAA, Hannu

Inventor： LABSYSTEMS OY

IPC: G01N33/553

CPC classification number: B03C1/28 ,  B03C1/01 ,  G01N33/54333 ,  G01N35/0098

Abstract: Method and equipment for carrying out immunoassays, wherein to a solution containing the antibody to be determined, magnetic particles (2) coated with the corresponding antigen as well as tracer particles (3) coated with the corresponding antigen are added, after the immunological reaction the magnetic particles and the tracer particles adhering to them by the intermediate of the antibody are separated from the reaction solution, and the radiation emitted by the separated particles is measured. The magnetic particles are separated from the reaction solution by pushing a magnetic piece (5) into the solution and by pulling it out of the solution after the magnetic particles have adhered to it, whereupon the radiation emitted by the separated particles is measured.

Abstract translation: 进行免疫测定的方法和设备，其中向包含待测定抗体的溶液中加入涂有相应抗原的磁性颗粒（2）以及涂有相应抗原的示踪剂颗粒（3），免疫反应后 从反应溶液中分离由抗体的中间体附着于它们的磁性粒子和示踪剂粒子，测定分离出的粒子发射的辐射。 通过将磁性片（5）推入溶液中并且在磁性颗粒粘附到溶液之后将其从溶液中拉出，从而将磁性颗粒与反应溶液分离，由此测量被分离的颗粒发射的辐射。