公开(公告)号：WO2020159368A1

公开(公告)日：2020-08-06

申请号：PCT/NL2020/050051

申请日：2020-01-30

Applicant: LAVA THERAPEUTICS B.V. ,  STICHTING VUmc

Inventor： VAN DER VLIET, Johannes Jelle ,  DE WEERDT, Iris ,  DE GRUIJL, Tanja Denise ,  PARREN, Paul ,  KATER, Aron Philip ,  SCHEFFER, George Lodewijk

IPC: C07K16/28 ,  A61P35/00

Abstract: The present invention relates to novel antibodies capable of binding human CD40 and to novel multispecific antibodies capable of binding human CD40 and capable of binding a human Vγ9Vδ2 T cell receptor. The invention further relates to pharmaceutical compositions comprising the antibodies of the invention and to uses of the antibodies of the invention for medical treatment.

公开(公告)号：WO2020060406A1

公开(公告)日：2020-03-26

申请号：PCT/NL2019/050625

申请日：2019-09-19

Applicant: LAVA THERAPEUTICS B.V.

Inventor： DE WEERDT, Iris ,  KATER, Arnon Philip ,  PARREN, Paul Willem Henri Ida ,  DE GRUIJL, Tanja Denise ,  VAN DER VLIET, Johannes Jelle ,  LAMERIS, Roeland

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/04

Abstract: The present invention relatestonovel methodsfor the treatment of hematological malignancies. In particular, the invention relatesto the treatment of hematological malignancies using antibodiescomprising a first binding moiety that is able to bind human CD1d and a second binding moiety that is able to bind the human Vγ9Vδ2-TCR.

公开(公告)号：EP3853255A1

公开(公告)日：2021-07-28

申请号：EP19828845.8

申请日：2019-09-19

Applicant: Lava Therapeutics B.V.

Inventor： DE WEERDT, Iris ,  KATER, Arnon Philip ,  PARREN, Paul Willem Henri Ida ,  DE GRUIJL, Tanja Denise ,  VAN DER VLIET, Johannes Jelle ,  LAMERIS, Roeland

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/04