Abstract:
PROBLEM TO BE SOLVED: To provide a device for photon counting and a method for the same.SOLUTION: A device for photon counting 10 comprises a detector unit 12, a switching unit 30, a sampling unit, a series-parallel conversion unit and an evaluation unit. The switching unit receives a collision by a detection signal 26 generated by the detector unit, and the sampling unit samples a state signal 32 generated by the switching unit and generates series sampling data. The series-parallel conversion unit groups the sampling data into sampling data packets. The evaluation unit operates at predetermined operation cycle time falling below a sampling frequency, and executes the steps of: evaluating at least one n-bit binary value in each of the sampling data packets within each clock cycle determined by the operation cycle time; identifying a partial counter counting result; adding the partial counter counting result identified within the individual clock cycle; and obtaining an overall counter counting result showing the number of detected photons.
Abstract:
PROBLEM TO BE SOLVED: To provide a detection device.SOLUTION: The detection device is embodied so as to receive light and generate an electric signal, and has a housing, a sensor arranged in the housing and a cooling element arranged in the housing. The cooling element electrically insulates the detector from the housing, or the cooling element is configured to be a part of an insulation body that electrically insulates the detector from the housing.
Abstract:
PROBLEM TO BE SOLVED: To provide a method and an apparatus for inspecting a sample.SOLUTION: Disclosed is a method and an apparatus for inspecting a sample. The apparatus includes: a light source for generating excitation rays of light with a pulse to be continuously generated with an excitation pulse frequency for illuminating a sample area with the excitation pulse; and a detector for detecting detection rays of light to be emitted from the sample area. In the apparatus, the detector generates an electric pulse and an electric pulse sequence based on the electric pulse for each of the detection photons of the detection rays of light. The apparatus includes an analog/digital converter for generating a digital data sequence by sampling the electric pulse sequence at a sampling speed.
Abstract:
PROBLEM TO BE SOLVED: To provide a method and an apparatus which image a sample with a scanning microscopy.SOLUTION: Disclosed are a method and an apparatus for imaging a sample (28) with a scanning microscopy. Multiple sample points are scanned with a scanning beam (14) in consecutive scanning time sections. An intensity of light emitted from each of the scanned sample points is sensed repeatedly within each of the related scanning time sections. Based on intensities sensed at each of the scanned sample points, an intensity average value is found as an average value image point signal. Then, by synthesizing such average value image point signals, an average value raster image signal is generated. Further, in addition, based on intensities sensed at each of the scanned sample points, an intensity variance value is found as a variance image point signal. Then, by synthesizing such variance image point signals, a variance raster image signal is generated.
Abstract:
PROBLEM TO BE SOLVED: To provide a method for measurement of a lifetime of excitation state in a sample.SOLUTION: The invention relates to a method for measurement of a lifetime of excitation state, especially a fluorescence lifetime, in a sample, and relates to a device for executing the method. The method includes: a first step of generating an excitation pulse and illuminating a sample area with the excitation pulse; a second step of generating a first digital data sequence that shows a power and time profile of the excitation pulse, and determining a first switching moment on the basis of the first digital data sequence; a third step of using a detector to detect detection light emitted from the sample area, generating a second digital data sequence that shows a power and time profile of the detection light, and determining a second switching moment on the basis of the second digital data sequence; and a last step of calculating a time difference between the first and second switching moments.
Abstract:
PROBLEM TO BE SOLVED: To provide a detection device.SOLUTION: The detection device is embodied so as to receive light and generate an electric signal, and has an optical sensor having a light incident surface and a cooling element. The cooling element comes into direct contact with the optical sensor on the light incidence surface of the optical sensor and/or a substrate that carries the optical sensor.
Abstract:
PROBLEM TO BE SOLVED: To provide a detection device.SOLUTION: The detection device is so designed as to receive light and generate an electric signal, and has a housing and a detector which is constituted in the housing. The purpose of the configuration is that a cooling element may be constituted in the housing, an optical path that extends through the cooling element may be designated for the detection object light, and/or a cooling element designed as an intermediate element having thermal conductivity and electrical insulation may be constituted in the housing, and/or an optical sensor of the detector especially a cooling element coming into direct contact with a photocathode and/or the optical sensor especially the cooling element coming into direct contact with a (especially transparent) substrate that carries the photocathode may be constituted in the housing.
Abstract:
PROBLEM TO BE SOLVED: To provide an apparatus and a method for detection with a scanning microscope. SOLUTION: The apparatus and the method for detection with the scanning microscope (1) are disclosed. The scanning microscope (1) encompasses a scanning device (7) that guides an illuminating light beam (3) through a scanning optical system (12) and a microscope optical system (13) and over or through a specimen (15). A digital circuit (30), which periodically interrogates the detected signals within a pixel (P x, y ) and calculates an average therefrom, is placed after a detection unit (19). COPYRIGHT: (C)2007,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To create a scanning microscope with which image quality is improved, system-related artifacts being avoided, and to create a method of using such a scanning microscope. SOLUTION: A scanning microscope (1) and a scanning method are disclosed. The scanning microscope (1) has, arranged in the illuminating light beam path, an outcoupling element (60) that couples out at least a fraction of the illuminating light beam (3) and directs it to a detector (61), that detects the pulse frequency of the light source that generates the illuminating light beam; and the pulse frequency serves as a basic clock frequency for a scanner. COPYRIGHT: (C)2007,JPO&INPIT