公开(公告)号：WO2020010030A1

公开(公告)日：2020-01-09

申请号：PCT/US2019/040210

申请日：2019-07-01

Applicant: LEIDOS, INC.

Inventor： CHAPPELL, Stephen A. ,  MAURO, Vincent P. ,  DRESIOS, John

IPC: C12P21/00 ,  C12P21/06 ,  C12P21/04 ,  C12Q1/68 ,  C12N15/00 ,  C07H21/04

Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.

公开(公告)号：EP3818168A1

公开(公告)日：2021-05-12

申请号：EP19830364.6

申请日：2019-07-01

Applicant: Leidos, Inc.

Inventor： CHAPPELL, Stephen A. ,  MAURO, Vincent P. ,  DRESIOS, John

IPC: C12P21/00 ,  C12P21/06 ,  C12P21/04 ,  C12Q1/68 ,  C12N15/00 ,  C07H21/04