公开(公告)号：WO2020010030A1

公开(公告)日：2020-01-09

申请号：PCT/US2019/040210

申请日：2019-07-01

Applicant: LEIDOS, INC.

Inventor： CHAPPELL, Stephen A. ,  MAURO, Vincent P. ,  DRESIOS, John

IPC: C12P21/00 ,  C12P21/06 ,  C12P21/04 ,  C12Q1/68 ,  C12N15/00 ,  C07H21/04

Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.

公开(公告)号：EP2654793B1

公开(公告)日：2017-09-13

申请号：EP11852145.9

申请日：2011-12-21

Applicant: Leidos, Inc.

Inventor： DRESIOS, John ,  GRIFFEY, Richard

IPC: G01N33/50 ,  G01N33/567

CPC classification number: G01N33/6887 ,  A61K9/1271 ,  A61K38/02 ,  A61K38/1777 ,  A61K39/44 ,  A61K47/42 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6847 ,  A61K49/0058 ,  C07K16/18 ,  G01N33/5088 ,  G01N33/567 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4712 ,  G01N2333/78

Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.

公开(公告)号：EP3818168A1

公开(公告)日：2021-05-12

申请号：EP19830364.6

申请日：2019-07-01

Applicant: Leidos, Inc.

Inventor： CHAPPELL, Stephen A. ,  MAURO, Vincent P. ,  DRESIOS, John

IPC: C12P21/00 ,  C12P21/06 ,  C12P21/04 ,  C12Q1/68 ,  C12N15/00 ,  C07H21/04

公开(公告)号：EP3263121A1

公开(公告)日：2018-01-03

申请号：EP17184825.2

申请日：2011-12-21

Applicant: Leidos, Inc.

Inventor： DRESIOS, John ,  GRIFFEY, Richard

IPC: A61K38/02 ,  G01N33/50 ,  G01N33/567

CPC classification number: G01N33/6887 ,  A61K9/1271 ,  A61K38/02 ,  A61K38/1777 ,  A61K39/44 ,  A61K47/42 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6847 ,  A61K49/0058 ,  C07K16/18 ,  G01N33/5088 ,  G01N33/567 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4712 ,  G01N2333/78

Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.

Abstract translation: 本公开涉及用于鉴定在伤口部位特异性暴露的细胞内，细胞外或细胞外基质蛋白质的蛋白质或肽基序的方法，以及用于治疗伤口的组合物，以及它们的使用方法。