公开(公告)号：WO2020237050A1

公开(公告)日：2020-11-26

申请号：PCT/US2020/033996

申请日：2020-05-21

Applicant: LEIDOS, INC.

Inventor： GUTIERREZ, Gabriel M. ,  KOTRAIAH, Vinayaka ,  PHARES, Timothy W. ,  PANNUCCI, James ,  MANSOUR, Marc

IPC: A61P35/00 ,  C07K7/00 ,  A61P25/28

Abstract: This disclosure provides peptides which bind to LAG3 and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.

公开(公告)号：EP3972696A1

公开(公告)日：2022-03-30

申请号：EP20732028.4

申请日：2020-05-21

Applicant: Leidos, Inc.

Inventor： GUTIERREZ, Gabriel M. ,  KOTRAIAH, Vinayaka ,  PHARES, Timothy W. ,  PANNUCCI, James ,  MANSOUR, Marc

IPC: A61P35/00 ,  C07K7/00 ,  A61P25/28