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公开(公告)号：WO2021247789A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/035580
申请日：2021-06-03
Applicant: LEIDOS, INC.
Inventor： GUTIERREZ, Gabriel M. , PANNUCCI, James , KOTRAIAH, Vinayaka , PHARES, Timothy W. , BROWNE, Cecille D.
IPC: C07K14/47 , C07K14/705 , A61K38/10 , A61K47/60 , A61K47/62 , C07K14/4747 , C07K14/70503 , C07K14/70596 , C07K2319/00
Abstract: This disclosure provides peptide conjugates that are useful for inhibiting the progression of a hyperproliferative disorder, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, enhancing a response to a vaccine, or inhibiting the progression of a synucleinopathy.
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公开(公告)号：WO2020237050A1
公开(公告)日：2020-11-26
申请号：PCT/US2020/033996
申请日：2020-05-21
Applicant: LEIDOS, INC.
Inventor： GUTIERREZ, Gabriel M. , KOTRAIAH, Vinayaka , PHARES, Timothy W. , PANNUCCI, James , MANSOUR, Marc
Abstract: This disclosure provides peptides which bind to LAG3 and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.
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公开(公告)号：WO2022081426A1
公开(公告)日：2022-04-21
申请号：PCT/US2021/054127
申请日：2021-10-08
Applicant: LEIDOS, INC.
Inventor： GUTIERREZ, Gabriel M. , PANNUCCI, James , WEIL, Michael Ryan , PHARES, Timothy W. , KOTRAIAH, Vinayaka , BROWNE, Cecille D. , BUONTEMPO, Peter J.
IPC: A61P35/00 , A61K38/10 , C07K7/08 , A01K2227/105 , A01K2267/0331 , A61K2039/505 , A61K2039/507 , A61K35/17 , A61K35/76 , A61K39/00 , A61K45/06 , A61P31/00 , A61Q7/00 , C07K14/70521 , C07K16/2818 , C07K2317/76 , C07K7/06 , C12N15/00 , C12N15/86
Abstract: This disclosure provides peptides which can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
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Patent Agency Ranking
公开(公告)号：WO2022026496A2
公开(公告)日：2022-02-03
申请号：PCT/US2021/043373
申请日：2021-07-28
Applicant: LEIDOS, INC.
Inventor： GUTIERREZ, Gabriel M. , PANNUCCI, James , KOTRAIAH, Vinayaka , PHARES, Timothy W. , BROWNE, Cecille D.
IPC: C07K14/705 , A61K39/39 , A61P25/28 , A61P35/00 , A61K38/10 , A61K45/06 , C07K14/70503 , C07K7/08
Abstract: This disclosure provides peptides that bind to LAG3 and can be used to block its interaction with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides, with their demonstrated activity and short half-life, can be used to activate cellular immunity while significantly reducing the potential for adverse events that is often associated with the antibodybased checkpoint inhibitors. The peptides can be used as stand-alone therapeutics or can be used as immune modulators in combination with other therapies.
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公开(公告)号：EP3972696A1
公开(公告)日：2022-03-30
申请号：EP20732028.4
申请日：2020-05-21
Applicant: Leidos, Inc.
Inventor： GUTIERREZ, Gabriel M. , KOTRAIAH, Vinayaka , PHARES, Timothy W. , PANNUCCI, James , MANSOUR, Marc
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公开(公告)号：EP4188947A2
公开(公告)日：2023-06-07
申请号：EP21769534.5
申请日：2021-07-28
Applicant: Leidos, Inc.
Inventor： GUTIERREZ, Gabriel M. , PANNUCCI, James , KOTRAIAH, Vinayaka , PHARES, Timothy W. , BROWNE, Cecille D.
IPC: C07K14/705 , A61K39/39 , A61P25/28 , A61P35/00
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公开(公告)号：EP4225444A1
公开(公告)日：2023-08-16
申请号：EP21801368.8
申请日：2021-10-08
Applicant: Leidos, Inc.
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公开(公告)号：EP4161952A1
公开(公告)日：2023-04-12
申请号：EP21736092.4
申请日：2021-06-03
Applicant: Leidos, Inc.
Inventor： GUTIERREZ, Gabriel M. , PANNUCCI, James , KOTRAIAH, Vinayaka , PHARES, Timothy W. , BROWNE, Cecille D.
IPC: C07K14/47 , C07K14/705
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