公开(公告)号：CA3141162A1

公开(公告)日：2020-11-26

申请号：CA3141162

申请日：2020-05-21

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PHARES TIMOTHY W ,  PANNUCCI JAMES ,  MANSOUR MARC

IPC: C07K7/08 ,  A61K38/17 ,  A61P35/00 ,  C07K14/00 ,  C07K14/705 ,  C07K19/00 ,  C12N5/10 ,  C12N7/01 ,  C12N15/62

Abstract: This disclosure provides peptides which bind to LAG3 and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and a-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.

公开(公告)号：AU2020279371A1

公开(公告)日：2021-12-23

申请号：AU2020279371

申请日：2020-05-21

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PHARES TIMOTHY W ,  PANNUCCI JAMES ,  MANSOUR MARC

IPC: A61P35/00 ,  A61P25/28 ,  C07K7/00

Abstract: This disclosure provides peptides which bind to LAG3 and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.