公开(公告)号：EP2807252A4

公开(公告)日：2015-10-14

申请号：EP13740994

申请日：2013-01-25

Applicant: LIFE TECHNOLOGIES CORP ,  UNIV JOHNS HOPKINS

Inventor： AGNEW BRIAN ,  GRAHAM DAVID

IPC: C12N7/00

CPC classification number: C12N7/00 ,  A61K39/00 ,  A61K48/00 ,  C12N2740/16034 ,  C12N2740/16045 ,  C12N2740/16051 ,  C12N2810/10

Abstract: Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The viruses labeled with alkyne-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

Abstract translation: 使用用炔烃修饰的生物分子（例如脂肪酸，碳水化合物和脂质）标记的病毒的方法来治疗植物，昆虫或感染病毒的动物或增加病毒如人类免疫缺陷病毒的感染性， 被提供。 还提供了用炔修饰的生物分子如脂肪酸，碳水化合物或类异戊二烯脂质来标记病毒（例如人类免疫缺陷病毒）的方法。 用炔烃修饰的生物分子标记的病毒可以与药学上可接受的赋形剂组合以产生药物组合物，任选地含有另一种抗病毒剂和/或递送剂，例如脂质体。

公开(公告)号：ZA201402552B

公开(公告)日：2019-06-26

申请号：ZA201402552

申请日：2014-04-08

Applicant: LIFE TECHNOLOGIES CORP

Inventor： AGNEW BRIAN ,  SINGH UPINDER ,  GRAHAM DAVID ,  GRECIAN SCOTT

Abstract: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

公开(公告)号：HK1185543A1

公开(公告)日：2014-02-21

申请号：HK13112929

申请日：2013-11-19

Applicant: LIFE TECHNOLOGIES CORP

Inventor： AGNEW BRIAN ,  GRAHAM DAVID ,  SINGH UPINDER ,  GRECIAN SCOTT

IPC: A61K20060101 ,  A61P20060101

公开(公告)号：BR112013003658B1

公开(公告)日：2022-02-22

申请号：BR112013003658

申请日：2011-07-28

Applicant: LIFE TECHNOLOGIES CORP

Inventor： AGNEW BRIAN ,  GRAHAM DAVID ,  GRECIAN SCOTT ,  SINGH UPINDER

IPC: A61K31/00 ,  A61K31/19 ,  A61K31/20 ,  A61P31/00 ,  A61P31/18

Abstract: composição farmacêutica compreendendo ácido graxo, carboidrato e lipídio de isoprenoide modificados com azida, uso de tais componentes e método para inibir infectividade de um vírus. a presente invenção refere-se a métodos de uso de biomoléculas modificadas com azida, tais como ácidos graxos, carboidratos e lipídios, para o tratamento de uma planta, um inseto ou um animal infectado com um vírus ou para inibir a infectividade de um vírus, tal como o vírus ou para inibir a infectividade de um vírus, tal como o vírus da imunodeficiência humana, são fornecidos. também são fornecidos métodos para identificar um vírus, tal como o vírus da imunodeficiência humana, com uma biomolécula modificada com azida, tal como um ácido graxo, um carboidrato ou um lipídio de isoprenoide. além disso, são proporcionados métodos para o rastreio de um vírus in vivo com uma biomolécula modificada com azida, tal como um ácido graxo, um carboidrato ou um lipídio de isoprenoide. as biomoléculas modificadas com azida podem ser combinadas com um excipiente farmaceuticamente aceitável para a produção de uma composição farmacêutica contendo, opcionalmente, um outro agente antiviral e/ou um agente de distribuição, tal como um lipossoma.

公开(公告)号：AU2013212068A1

公开(公告)日：2014-09-18

申请号：AU2013212068

申请日：2013-01-25

Applicant: LIFE TECHNOLOGIES CORP ,  UNIV JOHNS HOPKINS

Inventor： AGNEW BRIAN ,  GRAHAM DAVID

IPC: C12N7/00

Abstract: Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The viruses labeled with alkyne-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

公开(公告)号：SG11201404361UA

公开(公告)日：2014-09-26

申请号：SG11201404361U

申请日：2013-01-25

Applicant: LIFE TECHNOLOGIES CORP

Inventor： AGNEW BRIAN ,  GRAHAM DAVID

IPC: C12N7/00

Abstract: Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The viruses labeled with alkyne-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

公开(公告)号：ZA201300799B

公开(公告)日：2014-01-29

申请号：ZA201300799

申请日：2013-01-30

Applicant: LIFE TECHNOLOGIES CORP

Inventor： AGNEW BRIAN ,  SINGH UPINDER ,  GRAHAM DAVID ,  GRECIAN SCOTT

IPC: A61P20060101 ,  A61K20060101

Abstract: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

公开(公告)号：AU2013212068B2

公开(公告)日：2018-02-15

申请号：AU2013212068

申请日：2013-01-25

Applicant: LIFE TECHNOLOGIES CORP ,  UNIV JOHNS HOPKINS

Inventor： AGNEW BRIAN ,  GRAHAM DAVID

IPC: C12N7/00

Abstract: Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The viruses labeled with alkyne-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

公开(公告)号：BR112013003658A2

公开(公告)日：2016-09-06

申请号：BR112013003658

申请日：2011-07-28

Applicant: LIFE TECHNOLOGIES CORP

Inventor： AGNEW BRIAN ,  GRAHAM DAVID ,  GRECIAN SCOTT ,  SINGH UPINDER

IPC: A61K31/00 ,  A61K31/19 ,  A61K31/20 ,  A61P31/00 ,  A61P31/18

Abstract: compostos antivirais contendo azida. métodos de uso de biomoléculas modificadas com azida, tais como ácidos graxos, carboidratos e lipídios, para o tratamento de uma planta, um inseto ou um animal infectado com um vírus ou para inibir a infectividade de um vírus, tal como o vírus ou para inibir a infectividade de um vírus, tal como o vírus da imunodeficiência humana, são fornecidos. também são fornecidos métodos para identificar um vírus, tal como o vírus da imunodefiência humana com uma biomolécula modificada com azida, tal como um ácido graxo, um carboidrato ou um lipídio de isoprenóide. além disso, são proporcionados métodos para o rastreio de um vírus in vivo com uma biomolécula modificada com azida, tal como um ácido graxo, um carboidrato ou um lipídio de isoprenóide. as biomoléculas modificadas com azida podem ser combinadas com um excipiente farmaceuticamente aceitável para a produção de uma composição farmacêutica contendo, opcionalmente, um outro agente antiviral e/ou um agente de distribuição, tal como um lipossoma.