公开(公告)号：JP2013064745A

公开(公告)日：2013-04-11

申请号：JP2012246416

申请日：2012-11-08

Applicant: Life Technologies Corp ,  ライフ テクノロジーズ コーポレーション

Inventor： JONATHAN M ROTHBERG ,  WOLFGANG HINZ ,  KIM L JOHNSON ,  JAMES BUSTILLO

IPC: G01N27/414 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/28 ,  G01N27/416

CPC classification number: G01N27/4148 ,  C12Q1/6818 ,  C12Q1/6874 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  H01L27/088 ,  H01L29/42324 ,  H01L29/78 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01073 ,  H01L2924/14 ,  H01L2924/1433 ,  Y10T436/22 ,  C12Q2565/607 ,  C12Q2565/301 ,  C12Q2533/101

Abstract: PROBLEM TO BE SOLVED: To provide a method and an apparatus relating to a large scale FET for measuring an analyte.SOLUTION: ChemFET (e.g., ISFET) arrays may be manufactured by using conventional CMOS processing technique based on an improved FET pixel and array design that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel size and high-density arrays. Such arrays may be employed to detect presence and/or concentration change of an analyte of various types in a variety of chemical and/or biological processes. In one example, the chemFET arrays facilitate DNA sequencing technique based on monitoring change in hydrogen ion concentration (pH), change in other analyte concentration, and/or binding events associated with the chemical processes relating to DNA synthesis.

Abstract translation: 要解决的问题：提供与用于测量分析物的大规模FET相关的方法和装置。 解决方案：可以通过使用基于改进的FET像素和阵列设计的常规CMOS处理技术来制造ChemFET（例如，ISFET）阵列，其提高测量灵敏度和精度，并且同时促进显着小的像素尺寸和高精度 密度阵列。 可以使用这样的阵列来检测各种化学和/或生物过程中各种类型的分析物的存在和/或浓度变化。 在一个实例中，chemFET阵列基于监测氢离子浓度（pH）的变化，其他分析物浓度的变化和/或与与DNA合成相关的化学过程相关联的结合事件，促进DNA测序技术。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2015092163A

公开(公告)日：2015-05-14

申请号：JP2014245830

申请日：2014-12-04

Applicant: LIFE TECHNOLOGIES CORP

Inventor： JONATHAN M ROTHBERG ,  WOLFGANG HINZ ,  KIM L JOHNSON ,  JAMES BUSTILLO

IPC: G01N27/414 ,  C12M1/00 ,  C12Q1/68 ,  G01N37/00

Abstract: 【課題】分析物測定のための大規模FETアレイの動作方法を提供する。【解決手段】化学感応性電界効果トランジスタ(chemFET)の大規模アレイは、アレイの個々のchemFETセンサ素子に近接して起こる分析物濃度の変化を検出するよう構成される。第1のタイミング信号に応答して、アレイの複数のセンサの信号サンプルを生成し、選択信号に応答して、複数のセンサに結合された出力回路を有効化し、出力回路に信号サンプルを出力する。一方、参照電圧を参照セルに印加し、参照セルから出力回路に参照信号を出力する。【選択図】なし

公开(公告)号：JP2013064746A

公开(公告)日：2013-04-11

申请号：JP2012246417

申请日：2012-11-08

Applicant: Life Technologies Corp ,  ライフ テクノロジーズ コーポレーション

Inventor： JONATHAN M ROTHBERG ,  WOLFGANG HINZ ,  KIM L JOHNSON ,  JAMES BUSTILLO

IPC: G01N27/414 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/28 ,  G01N27/416

CPC classification number: G01N27/4148 ,  C12Q1/6818 ,  C12Q1/6874 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  H01L27/088 ,  H01L29/42324 ,  H01L29/78 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01073 ,  H01L2924/14 ,  H01L2924/1433 ,  Y10T436/22 ,  C12Q2565/607 ,  C12Q2565/301 ,  C12Q2533/101

Abstract: PROBLEM TO BE SOLVED: To provide a method and an apparatus relating to a large scale FET for measuring an analyte.SOLUTION: ChemFET (e.g., ISFET) arrays may be manufactured by using conventional CMOS processing technique based on an improved FET pixel and array design that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel size and high-density arrays. Such arrays may be employed to detect presence and/or concentration change of an analyte of various types in a variety of chemical and/or biological processes. In one example, the chemFET arrays facilitate DNA sequencing technique based on monitoring change in hydrogen ion concentration (pH), change in other analyte concentration, and/or binding events associated with the chemical processes relating to DNA synthesis.

公开(公告)号：JP2013064744A

公开(公告)日：2013-04-11

申请号：JP2012246415

申请日：2012-11-08

Applicant: Life Technologies Corp ,  ライフ テクノロジーズ コーポレーション

Inventor： JONATHAN M ROTHBERG ,  WOLFGANG HINZ ,  KIM L JOHNSON ,  JAMES BUSTILLO

IPC: G01N27/414 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N27/28

CPC classification number: G01N27/4148 ,  C12Q1/6818 ,  C12Q1/6874 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  H01L27/088 ,  H01L29/42324 ,  H01L29/78 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01073 ,  H01L2924/14 ,  H01L2924/1433 ,  Y10T436/22 ,  C12Q2565/607 ,  C12Q2565/301 ,  C12Q2533/101

Abstract: PROBLEM TO BE SOLVED: To provide a method and an apparatus relating to a large scale FET for measuring an analyte.SOLUTION: ChemFET (e.g., ISFET) arrays may be manufactured by using conventional CMOS processing technique based on an improved FET pixel and array design that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel size and high-density arrays. Such arrays may be employed to detect presence and/or concentration change of an analyte of various types in a variety of chemical and/or biological processes. In one example, the chemFET arrays facilitate DNA sequencing technique based on monitoring change in hydrogen ion concentration (pH), change in other analyte concentration, and/or binding events associated with the chemical processes relating to DNA synthesis.