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    Methods and systems for visualizing and evaluating data
    2.
    发明授权
    Methods and systems for visualizing and evaluating data 有权

    公开(公告)号：US12176072B2

    公开(公告)日：2024-12-24

    申请号：US16590303

    申请日：2019-10-01

    Applicant: Life Technologies Corporation

    Inventor： Gordon A. Janaway ,  Manjula Aliminati ,  Ruoyun Wu ,  David Fortescue ,  Ming Shen

    IPC: G16B40/10 ,  C12Q1/6851 ,  G16B40/00

    Abstract: A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time amplification during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.

    Visualization tool for qPCR genotyping data
    3.
    发明授权
    Visualization tool for qPCR genotyping data 有权

    公开(公告)号：US10127348B2

    公开(公告)日：2018-11-13

    申请号：US15206109

    申请日：2016-07-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Gordon A. Janaway ,  Evelyn Wing-Sim Chan

    IPC: G06F3/048 ,  G06F19/18 ,  G06F19/26 ,  G06F3/0482 ,  G06F3/0485

    Abstract: Systems and methods are used to display data obtained from a qPCR instrument. Each of two or more samples is probed with a first labeling probe and a second labeling probe. A first data set is received from a qPCR instrument at a first cycle number that includes for each sample a first labeling probe intensity, and a second labeling probe intensity. A second data set is received at a second cycle number that includes for each sample a first labeling probe intensity and a second labeling probe intensity. A first plot of first labeling probe intensity as a function of second labeling probe intensity is created using the first data set. A second plot of first labeling probe intensity as a function of second labeling probe intensity is created using the second data set. The first plot and the second plot are displayed in response to user defined input to provide dynamic and real-time analysis of genotyping data.

    Methods and systems for visualizing and evaluating data
    4.
    发明授权
    Methods and systems for visualizing and evaluating data 有权

    公开(公告)号：US10453557B2

    公开(公告)日：2019-10-22

    申请号：US14347864

    申请日：2012-09-28

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Gordon A. Janaway ,  Manjula Aliminati ,  Ruoyun Wu ,  David Fortescue ,  Ming Shen

    IPC: G16B40/00 ,  C12Q1/6851

    Abstract: A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data. A dPCR result is generated based on the positive or negative amplification determinations for the plurality of samples.

    Visualization Tool for qPCR Genotyping Data
    5.
    发明申请
    Visualization Tool for qPCR Genotyping Data 审中-公开
    qPCR基因分型数据可视化工具

    公开(公告)号：US20170011165A1

    公开(公告)日：2017-01-12

    申请号：US15206109

    申请日：2016-07-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Gordon A. Janaway ,  Evelyn Wing-Sim Chan

    IPC: G06F19/18 ,  G06F3/0482 ,  G06F19/26

    CPC classification number: G06F19/18 ,  G06F3/0482 ,  G06F3/0485 ,  G06F19/26

    Abstract: Systems and methods are used to display data obtained from a qPCR instrument. Each of two or more samples is probed with a first labeling probe and a second labeling probe. A first data set is received from a qPCR instrument at a first cycle number that includes for each sample a first labeling probe intensity, and a second labeling probe intensity. A second data set is received at a second cycle number that includes for each sample a first labeling probe intensity and a second labeling probe intensity. A first plot of first labeling probe intensity as a function of second labeling probe intensity is created using the first data set. A second plot of first labeling probe intensity as a function of second labeling probe intensity is created using the second data set. The first plot and the second plot are displayed in response to user defined input to provide dynamic and real-time analysis of genotyping data.

    Abstract translation: 系统和方法用于显示从qPCR仪器获得的数据。 用第一标记探针和第二标记探针探测两个或更多个样品中的每一个。 从qPCR仪器以第一周期数接收第一数据集，其中包括针对每个样本的第一标记探针强度和第二标记探针强度。 以第二周期数接收第二数据集，其中为每个样本包括第一标记探针强度和第二标记探针强度。 使用第一数据集创建第一标记探针强度作为第二标记探针强度的函数的第一图。 使用第二数据集创建第二标记探针强度作为第二标记探针强度的函数的第二图。 显示第一个绘图和第二个绘图以响应用户定义的输入，以提供对基因分型数据的动态和实时分析。

    SYSTEM AND METHOD FOR DETERMINING COPIES-PER-UNIT-VOLUME USING PCR AND FLOW CONTROL OF DROPLETS
    6.
    发明申请
    SYSTEM AND METHOD FOR DETERMINING COPIES-PER-UNIT-VOLUME USING PCR AND FLOW CONTROL OF DROPLETS 审中-公开
    使用PCR和流量控制法确定复制单位体积的系统和方法

    公开(公告)号：US20160208342A1

    公开(公告)日：2016-07-21

    申请号：US15080801

    申请日：2016-03-25

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Gordon A. Janaway ,  Mark Andersen ,  Kornelija Zgonc ,  Michael C. Pallas ,  Marcin Sikora ,  Casey R. McFarland ,  Ferrier N. Le ,  Haopeng Wang ,  Jian Gong ,  Gothami Padmabandu

    IPC: C12Q1/68 ,  G01N21/64

    CPC classification number: C12Q1/6886 ,  C12Q1/686 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N21/6486 ,  C12Q2537/16 ,  C12Q2563/143 ,  C12Q2563/159 ,  C12Q2565/626

    Abstract: Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality of discrete sample portions to form a plurality of discrete processed sample portions. At least one discrete processed sample portion containing nucleic acid amplification reaction products. Fluorescence signals are detected from the at least one of the plurality of discrete processed sample portions to determine a presence of the at least one target nucleic acid. The method also includes determining the respective volumes of the plurality of the plurality of discrete processed sample portions, and estimating the number of copies-per-unit-volume of the at least one target nucleic acid in the sample. Estimating the number of copies-per-unit-volume is based on the number of discrete processed sample portions determined to contain the at least one target nucleic acid therein.

    Abstract translation: 提供了用于定量样品中靶核酸的方法和系统。 该方法包括形成多个离散的样本部分。 多个离散样品部分中的每一个包含样品的一部分和反应混合物。 该方法还包括放大多个离散样本部分以形成多个离散处理的样本部分。 至少一个离散加工的样品部分含有核酸扩增反应产物。 从所述多个离散处理样品部分中的至少一个检测荧光信号以确定所述至少一种靶核酸的存在。 该方法还包括确定多个多个离散处理的样本部分的相应体积，以及估计样品中至少一个靶核酸的每单位体积的拷贝数。 估计每单位体积的拷贝数是基于确定为在其中含有至少一种靶核酸的离散加工样品部分的数量。

    METHODS AND SYSTEMS FOR VISUALIZING AND EVALUATING DATA
    10.
    发明申请
    METHODS AND SYSTEMS FOR VISUALIZING AND EVALUATING DATA 审中-公开

    公开(公告)号：US20200035329A1

    公开(公告)日：2020-01-30

    申请号：US16590303

    申请日：2019-10-01

    Applicant: Life Technologies Corporation

    Inventor： Gordon A. Janaway ,  Manjula Aliminati ,  Ruoyun Wu ,  David Fortescue ,  Ming Shen

    IPC: G16B40/00 ,  C12Q1/6851

    Abstract: A computer-implemented method of generating a digital polymerase chain reaction (dPCR) result is provided. The method includes detecting of emission data from a planiality of samples, each included in a sample region of a plurality of sample regions, at a first time amplification period. The method further includes determining a positive or negative amplification determination for each sample of the plurality of samples based in part on the first set of emission data, A dPCR result is generated based on the positive amplification determinations for the plurality of samples.

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