公开(公告)号：WO2019143478A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/012126

申请日：2019-01-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： JONES, Nephi ,  KJAR, Steven ,  PRICE, Daniel ,  SMITH, Mark ,  THACKER, Paul

IPC: C12M1/00 ,  C12M1/06 ,  C12M1/34 ,  C12M3/00

CPC classification number: B01F7/00391 ,  B01F3/04531 ,  B01F7/0005 ,  B01F7/00725 ,  B01F7/18 ,  B01F7/24 ,  B01F15/00538 ,  B01F15/00707 ,  B01F15/00772 ,  B01F15/0085 ,  B01F2003/04673 ,  B01F2015/0011 ,  B01F2015/00603 ,  B01F2215/0073 ,  C12M23/50 ,  C12M23/58 ,  C12M27/02 ,  C12M27/06 ,  C12M35/04 ,  C12M41/48 ,  C12N5/0602 ,  C12N2527/00

Abstract: The present set of embodiments relate a system, method, and various devices for installation of a bioproduction system. The bioproduction system includes a rigid housing having a moveable platform to assist in the installation of a bioprocessing container within. The system also includes mounting systems for a variety of peripherals originating from the flexible container while safeguarding operators. More specifically, the system includes systems and methods for mounting bearings, organizing tube sets, and placement of the flexible container in its proper orientation.

公开(公告)号：WO2019143476A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/012120

申请日：2019-01-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： BRAU, Christopher ,  JONES, Nephi ,  SMITH, Mark

IPC: C12M1/00 ,  C12M1/06 ,  C12M1/34

CPC classification number: B01F7/00391 ,  B01F3/04531 ,  B01F7/0005 ,  B01F7/00725 ,  B01F7/18 ,  B01F7/24 ,  B01F15/00538 ,  B01F15/00707 ,  B01F15/00772 ,  B01F15/0085 ,  B01F2003/04673 ,  B01F2015/0011 ,  B01F2015/00603 ,  B01F2215/0073 ,  C12M23/50 ,  C12M23/58 ,  C12M27/02 ,  C12M27/06 ,  C12M35/04 ,  C12M41/48 ,  C12N5/0602 ,  C12N2527/00

Abstract: The present set of embodiments relate to a bioproduction system, method, and apparatus for creating a scalable bioreactor system. Specifically, the present set of embodiments enable the determination of bioreaction performance characteristics of a commercial scale by matching operational parameters between a small test scale bioreaction to that of a commercial scale bioreaction. The system and methods do not rely on simply making bioreactor apparatuses across scales the same dimensionally which would not account for differences in fluid dynamic properties between very small to very large volumes, but requires tuning of a variety of systems (mixing assembly, sparger system, and headspace airflow system) in conjunction with one another to achieve predictive outcomes.

公开(公告)号：WO2021203057A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/025659

申请日：2021-04-02

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： JONES, Nephi ,  HSIAO, Tony ,  SMITH, Mason

IPC: B01F1/00 ,  B01F3/12 ,  B01F5/04 ,  B01F5/10 ,  B01F7/00 ,  B01F15/02 ,  B01F13/10 ,  B01F13/1055 ,  B01F15/0251 ,  B01F2003/125 ,  B01F3/1221 ,  B01F5/0415 ,  B01F5/043 ,  B01F5/106 ,  B01F7/0025

Abstract: A powder mixing system (12) includes a conduit (40) having a first end and an opposing second end, the conduit bounding a passage; a fluid pump (80) fluid coupled with the conduit, the fluid pump being configured to pump a liquid through the passage of the conduit; and a tubular transfer member (190) in fluid communication with the conduit, the transfer member being configured to couple with a powder bag housing a powder. The mixing system further including: (1) an eductor coupled to the transfer member and disposed in-line with the conduit so that the liquid pumped through the conduit also passes through the eductor; and/or (2) an auger assembly comprising an auger blade, at least a portion of the auger assembly being rotatably disposed within the transfer member.

公开(公告)号：EP3740559A1

公开(公告)日：2020-11-25

申请号：EP19701410.3

申请日：2019-01-03

Applicant: Life Technologies Corporation

Inventor： BRAU, Christopher ,  JONES, Nephi ,  SMITH, Mark

IPC: C12M1/00 ,  C12M1/06 ,  C12M1/34

公开(公告)号：EP3292897A1

公开(公告)日：2018-03-14

申请号：EP17193579.4

申请日：2011-01-19

Applicant: Life Technologies Corporation

Inventor： GOODWIN, Michael ,  STAHELI, Clinton ,  JONES, Nephi

IPC: B01D5/00 ,  B01F3/04 ,  B01F7/00 ,  B01F7/16 ,  B01F7/18 ,  B01F15/00 ,  C12M1/00 ,  C12M1/06 ,  C12M1/12 ,  B01F15/06

CPC classification number: C12M23/14 ,  B01D5/0072 ,  B01D47/05 ,  B01F3/04241 ,  B01F3/04531 ,  B01F7/00691 ,  B01F7/1695 ,  B01F7/18 ,  B01F7/22 ,  B01F15/00071 ,  B01F15/00831 ,  B01F15/0085 ,  B01F15/065 ,  B01F2003/04191 ,  B01F2003/04297 ,  B01F2003/04673 ,  B01F2003/04865 ,  B01F2003/04872 ,  B01F2003/04879 ,  B01F2003/04893 ,  B01F2003/04921 ,  B01F2015/061 ,  B01F2215/0073 ,  C12M23/26 ,  C12M23/34 ,  C12M27/02 ,  C12M29/00 ,  C12M29/06 ,  C12M29/24 ,  C12M37/00 ,  C12M41/14 ,  C12M41/18 ,  C12N1/10 ,  C12N1/12 ,  C12N1/14 ,  C12N1/20 ,  C12N5/00 ,  C12N5/04 ,  C12N5/10 ,  F28B1/02 ,  F28D2021/0063 ,  F28F3/12 ,  F28F21/06 ,  F28F21/065 ,  F28F2255/02

Abstract: Condenser assembly, comprising a condenser (110), means for cooling the condenser, and a condenser bag (210, 226, 228) removably coupled with the condenser, the condenser bag bounding a first compartment (242), the condenser bag having a first gas inlet port (248), a first gas exhaust port (250) and a first fluid collection port (244) each communication with the first compartment.

Abstract translation: 冷凝器组件，包括冷凝器（110），用于冷却冷凝器的装置以及与冷凝器可移除地联接的冷凝器袋（210,226,228），冷凝器袋界定第一隔室（242），冷凝器袋具有第一 气体入口端口（248），第一气体排出端口（250）和第一流体收集端口（244），每个都与第一隔室连通。

公开(公告)号：EP3808437A1

公开(公告)日：2021-04-21

申请号：EP20213225.4

申请日：2011-01-19

Applicant: Life Technologies Corporation

Inventor： GOODWIN, Michael ,  STAHELI, Clinton ,  JONES, Nephi

IPC: B01F3/04 ,  B01F7/00 ,  B01F7/16 ,  B01F7/18 ,  B01F15/00 ,  C12M1/00 ,  C12M1/06 ,  C12M1/12 ,  F28F3/12 ,  F28F21/06 ,  B01F15/06 ,  F28D21/00

Abstract: A condenser assembly comprises a condenser (110) comprising a first condenser body (114) having a first side face (116) and an opposing second side face (118), the first condenser body bounding a channel (136) extending therein; means for cooling the condenser, the means for cooling being in communication with the channel of the first condenser body; and a condenser bag (210, 226, 228) removably coupled with the condenser, the condenser bag bounding: a first compartment (242), the condenser bag having a first gas inlet port (248), a first gas exhaust port (250) and a first fluid collection port (244) each communication with the first compartment; and a second compartment (242') having a second gas inlet port (248'), a second gas exhaust port (250') and a second fluid collection port (244') each communication with the second compartment.

公开(公告)号：EP4126317A1

公开(公告)日：2023-02-08

申请号：EP21721719.9

申请日：2021-04-02

Applicant: Life Technologies Corporation

Inventor： JONES, Nephi ,  HSIAO, Tony ,  SMITH, Mason

IPC: B01F1/00 ,  B01F3/12 ,  B01F5/04 ,  B01F5/10 ,  B01F7/00 ,  B01F15/02 ,  B01F13/10

公开(公告)号：EP3740561A1

公开(公告)日：2020-11-25

申请号：EP19702136.3

申请日：2019-01-03

Applicant: Life Technologies Corporation

Inventor： JONES, Nephi ,  KJAR, Steven ,  MILLS, Brycen ,  SMITH, Mark ,  WEST, Derik

IPC: C12M1/00 ,  C12M1/06 ,  C12M1/34 ,  C12M3/00

公开(公告)号：EP3740560A1

公开(公告)日：2020-11-25

申请号：EP19701745.2

申请日：2019-01-03

Applicant: Life Technologies Corporation

Inventor： JONES, Nephi ,  KJAR, Steven ,  PRICE, Daniel ,  SMITH, Mark ,  THACKER, Paul

IPC: C12M1/00 ,  C12M1/06 ,  C12M1/34 ,  C12M3/00