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    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING
    1.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING 审中-公开

    公开(公告)号：WO2020018837A1

    公开(公告)日：2020-01-23

    申请号：PCT/US2019/042474

    申请日：2019-07-18

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： LOONEY, Timothy ,  LOWMAN, Geoffrey ,  LIN, Lifeng ,  YANG, Chenchen

    IPC: C12Q1/6881

    Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.

    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING
    2.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING 审中-公开

    公开(公告)号：WO2018136562A2

    公开(公告)日：2018-07-26

    申请号：PCT/US2018/014111

    申请日：2018-01-17

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： LOONEY, Timothy ,  LOWMAN, Geoffrey ,  LIN, Lifeng

    IPC: C12Q1/6881 ,  C07K14/725 ,  C12Q1/6883

    Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and or differences associated with the immune cell repertoire of a biological sample.

    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING 审中-公开

    公开(公告)号：WO2020018836A1

    公开(公告)日：2020-01-23

    申请号：PCT/US2019/042473

    申请日：2019-07-18

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： LOONEY, Timothy ,  YANG, Chenchen ,  LOWMAN, Geoffrey

    IPC: C12Q1/6881

    Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of nucleic acid sequences of murine T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.

    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING
    4.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE SEQUENCING 审中-公开

    公开(公告)号：WO2018136562A3

    公开(公告)日：2018-07-26

    申请号：PCT/US2018/014111

    申请日：2018-01-17

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： LOONEY, Timothy ,  LOWMAN, Geoffrey ,  LIN, Lifeng

    IPC: C12Q1/6881 ,  C07K14/725 ,  C12Q1/6883

    Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and or differences associated with the immune cell repertoire of a biological sample.

    IMMUNE REPERTOIRE BIOMARKERS FOR PREDICTION OF TREATMENT RESPONSE IN AUTOIMMUNE DISEASE
    5.
    发明申请
    IMMUNE REPERTOIRE BIOMARKERS FOR PREDICTION OF TREATMENT RESPONSE IN AUTOIMMUNE DISEASE 审中-公开

    公开(公告)号：WO2023023122A1

    公开(公告)日：2023-02-23

    申请号：PCT/US2022/040554

    申请日：2022-08-17

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： SARDA, Shrutii ,  LOWMAN, Geoffrey

    IPC: G01N33/50 ,  G01N33/68 ,  C12Q1/6881 ,  C12Q1/6883

    Abstract: Prediction of a clinical response to a therapy of a subject with an autoimmune disease based on B cell immune repertoire may include determining a plurality of clone frequencies in a biological sample from the subject, wherein the clone frequencies include: IgM, IgD, IgG3, IgG4, IgA, IgM with first somatic hypermutation (SHM) level, IgG1 with second SHM level. A plurality of decision criteria may be applied to features including the plurality of clone frequencies. Each decision criterion applies at least one threshold to a feature, wherein the plurality of decision criteria provides a plurality of output values. The plurality of output values may be summed and a sigmoid transformation may be applied to the summed value to form a prediction value. The prediction value may be compared to a final threshold to identify the subject as a likely responder or non-responder to an autoimmune disease therapy.

    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE MONITORING
    6.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE MONITORING 审中-公开

    公开(公告)号：WO2022109540A1

    公开(公告)日：2022-05-27

    申请号：PCT/US2021/072421

    申请日：2021-11-16

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： LOWMAN, Geoffrey ,  YANG, Chenchen ,  LOONEY, Timothy

    IPC: C12Q1/6881 ,  C12Q1/6883

    Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, methods provide for determining convergence of T cell receptor beta and T cell receptor gamma repertoires in samples prior to a treatment and predicting a subject's response to the treatment. In another aspect, methods provide predicting a subject's potential or predisposition to be protected from or vulnerable to an adverse event following a treatment.

    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE MONITORING
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR IMMUNE REPERTOIRE MONITORING 审中-公开

    公开(公告)号：WO2022104391A1

    公开(公告)日：2022-05-19

    申请号：PCT/US2021/072434

    申请日：2021-11-16

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： LOWMAN, Geoffrey ,  YANG, Chenchen ,  LOONEY, Timothy

    IPC: C12Q1/6806 ,  C12Q1/6858

    Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of B cell receptor heavy and light chains in a single assay, with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.

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