公开(公告)号：WO2017197217A1

公开(公告)日：2017-11-16

申请号：PCT/US2017/032324

申请日：2017-05-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： IPPOLITO, Kim ,  PAULLIN, Jonathan ,  SALISBURY, Richard ,  STONE, Laurel ,  MELIOUS, Ethan ,  ZIEGENFUSS, Audra ,  PERSMARK, Erik

IPC: G02B21/36

Abstract: Provided are systems and methods that allow a user to capture images at low- and high-level magnification and then overlay the high-level magnification images on the low-level magnification image to ease review of the images. The high-level magnification images may be overlaid on the low-level magnification image based at least in part on the portion of the low-level magnification image from which the high-level image was originated.

Abstract translation: 提供允许用户以低和高等级放大率拍摄图像然后覆盖低等级放大率图像上的高等级放大率图像以便于查看图像的系统和方法 。 至少部分地基于低级别放大图像的源自高级别图像的部分，高级别放大图像可以被覆盖在低级别放大图像上。

公开(公告)号：WO2022081863A2

公开(公告)日：2022-04-21

申请号：PCT/US2021/055008

申请日：2021-10-14

Applicant: LIFE TECHNOLOGIES CORPORATION ,  CELLOMICS, INC.

Inventor： ROGNIN, Nicolas ,  RYSTROM, Larry ,  GOCLUB, Ognjen ,  PAULLIN, Jonathan ,  DILIANI, Nicholas ,  IPPOLITO, Kim

IPC: G02B7/38 ,  G02B21/24 ,  G06T7/10 ,  G06T7/155 ,  G06T7/187 ,  G01N21/00 ,  G02B21/36 ,  G01N15/1434 ,  G01N2015/1452 ,  G01N2015/1486 ,  G02B21/244 ,  G02B21/367 ,  G06N3/0481 ,  G06N3/08 ,  G06T3/40 ,  G06V20/69 ,  G06V20/695

Abstract: Systems and methods for autofocus using artificial intelligence include (i) capturing a plurality of monochrome images over a nominal focus range, (ii) identifying one or more connected components within each monochrome image, (iii) sorting the identified connected components based on a number of pixels associated with each connected component, (iv) generating a focus quality estimate of at least a portion of the sorted connected components using a machine learning module, and (iv) calculating a target focus position based on the focus quality estimate of the evaluated connected components. The calculated target focus position can be used to perform cell counting using artificial intelligence, such as by (i) generating a seed likelihood image and a whole cell likelihood image based on output- a convolutional neural network and (ii) generating a mask indicative quantity and/or pixel locations of objects based on the seed likelihood image.

公开(公告)号：WO2019200116A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/027013

申请日：2019-04-11

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： BERRETTA, Marc ,  MECHAM, Jason ,  METTING, Frank ,  PAULLIN, Jonathan ,  BOESCHOTEN, Paul ,  PERSMARK, Erik ,  ALTENDORF, Eric

IPC: G02B21/08 ,  G02B21/36

Abstract: Apparatuses, systems and methods for generating color video with a monochrome sensor include the acts of (i) selectively energizing each of a plurality of light sources in a sequence, (ii) capturing a monochrome image of the illuminated sample at a monochrome sensor at each stage of the sequence, and (iii) generating a color video from the monochrome images. The sequence can have a series of stages with each stage of the sequence corresponding to activation of a different wavelength of light from the light sources to illuminate a sample. Generating the monochrome video can include the acts of compiling a plurality of monochrome images captured at the monochrome sensor with a single light source into a series of monochrome video frames comprising the monochrome video.

公开(公告)号：EP3776055A1

公开(公告)日：2021-02-17

申请号：EP19719151.3

申请日：2019-04-11

Applicant: Life Technologies Corporation

Inventor： BERRETTA, Marc ,  MECHAM, Jason ,  METTING, Frank ,  PAULLIN, Jonathan ,  BOESCHOTEN, Paul ,  PERSMARK, Erik ,  ALTENDORF, Eric

IPC: G02B21/08 ,  G02B21/36

公开(公告)号：EP4229460A2

公开(公告)日：2023-08-23

申请号：EP21805753.7

申请日：2021-10-14

Applicant: Life Technologies Corporation ,  Cellomics, Inc

Inventor： ROGNIN, Nicolas ,  RYSTROM, Larry ,  GOLUB, Ognjen ,  PAULLIN, Jonathan ,  DILIANI, Nicholas ,  IPPOLITO, Kim

IPC: G02B7/38 ,  G02B21/24 ,  G06T7/10 ,  G06T7/155 ,  G06T7/187 ,  G01N21/00 ,  G02B21/36

公开(公告)号：EP3455664A1

公开(公告)日：2019-03-20

申请号：EP17729236.4

申请日：2017-05-12

Applicant: Life Technologies Corporation

Inventor： IPPOLITO, Kim ,  PAULLIN, Jonathan ,  SALISBURY, Richard ,  STONE, Laurel ,  MELIOUS, Ethan ,  ZIEGENFUSS, Audra ,  PERSMARK, Erik

IPC: G02B21/36