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公开(公告)号：WO2014165710A2
公开(公告)日：2014-10-09
申请号：PCT/US2014/032888
申请日：2014-04-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： RHODES, Daniel , SADIS, Seth , WYNGAARD, Peter , BANKHEAD, Armand , CYANAM, Dinesh , KHAZANOV, Nikolay
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/156
Abstract: The disclosure provides gene fusion variants and novel associations with disease states, as well as kits, probes, and methods of using the same.
Abstract translation: 本公开提供了基因融合变体和与疾病状态的新型关联，以及试剂盒，探针及其使用方法。
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公开(公告)号：WO2015149034A3
公开(公告)日：2015-10-01
申请号：PCT/US2015/023197
申请日：2015-03-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： RHODES, Daniel , SADIS, Seth , WYNGAARD, Peter , KHAZANOV, Nikolay , BANDLA, Santhoshi , TOMILO, Mark , EDDY, Sean , BOWDEN, Emma , LI, Jia
IPC: C12Q1/68
Abstract: The disclosure provides gene fusions, gene variants, and novel associations with disease states, as well as kits, probes, and methods of using the same.
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公开(公告)号：WO2014172046A9
公开(公告)日：2014-10-23
申请号：PCT/US2014/029592
申请日：2014-03-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： RHODES, Daniel , SADIS, Seth , WYNGAARD, Peter , KHAZANOV, Nikolay , BANDLA, Santhoshi , TOMILO, Mark , EDDY, Sean , BOWDEN, Emma
Abstract: The disclosure provides gene fusions, gene variants, and novel associations with disease states, as well as kits, probes, and methods of using the same.
Abstract translation: 本披露提供了基因融合体，基因变体和与疾病状态的新型关联，以及使用它们的试剂盒，探针和方法。
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公开(公告)号：WO2014144121A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028404
申请日：2014-03-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： BANDLA, Santhoshi , ROSS, Douglas , SADIS, Seth , WYNGAARD, Peter
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/156
Abstract: The disclosure provides compositions, kits, and methods for detecting a plurality of genes and associated variants in a sample from a subject with lung cancer. The compositions, kits, and methods include a set of oligonucleotides, typically primers and/or probes that can hybridize to identify a gene variant. The methods disclosed herein provide for a mutation status of a tumor to be determined and subsequently associated with an actionable treatment recommendation.
Abstract translation: 本公开提供了用于检测来自肺癌受试者的样品中的多个基因和相关变体的组合物，试剂盒和方法。 组合物，试剂盒和方法包括一组寡核苷酸，通常可以杂交以鉴定基因变体的引物和/或探针。 本文公开的方法提供待确定的肿瘤的突变状态并随后与可行动的治疗推荐相关联。
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5.发明公开GENE FUSIONS AND GENE VARIANTS ASSOCIATED WITH CANCER 有权GENFUSIONEN UND GENVARIANTEN IM ZUSAMMENHANG MIT KREBS
公开(公告)号：EP2986736A2
公开(公告)日：2016-02-24
申请号：EP14721666.7
申请日：2014-03-14
Applicant: Life Technologies Corporation
Inventor： RHODES, Daniel , SADIS, Seth , WYNGAARD, Peter , KHAZANOV, Nikolay , BANDLA, Santhoshi , TOMILO, Mark , EDDY, Sean , BOWDEN, Emma
Abstract: The disclosure provides gene fusions, gene variants, and novel associations with disease states, as well as kits, probes, and methods of using the same.
Abstract translation: 本公开提供了基因融合，基因变体和与疾病状态的新型关联，以及试剂盒，探针及其使用方法。
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Patent Agency Ranking
公开(公告)号：EP3434788A1
公开(公告)日：2019-01-30
申请号：EP18194185.7
申请日：2014-03-14
Applicant: Life Technologies Corporation
Inventor： BANDLA, Santhoshi , ROSS, Douglas , SADIS, Seth , WYNGAARD, Peter
IPC: C12Q1/68
Abstract: The disclosure provides compositions, kits, and methods for detecting a plurality of genes and associated variants in a sample from a subject with lung cancer. The compositions, kits, and methods include a set of oligonucleotides, typically primers and/or probes that can hybridize to identify a gene variant. The methods disclosed herein provide for a mutation status of a tumor to be determined and subsequently associated with an actionable treatment recommendation.
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公开(公告)号：EP3122901B1
公开(公告)日：2018-08-15
申请号：EP15716320.5
申请日：2015-03-27
Applicant: Life Technologies Corporation
Inventor： RHODES, Daniel , SADIS, Seth , WYNGAARD, Peter , KHAZANOV, Nikolay , BANDLA, Santhoshi , TOMILO, Mark , EDDY, Sean , BOWDEN, Emma , LI, Jia
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/156
Abstract: The disclosure provides gene fusions, gene variants, and novel associations with disease states, as well as kits, probes, and methods of using the same.
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公开(公告)号：EP2981621A2
公开(公告)日：2016-02-10
申请号：EP14722494.3
申请日：2014-04-03
Applicant: Life Technologies Corporation
Inventor： RHODES, Daniel , SADIS, Seth , WYNGAARD, Peter , BANKHEAD, Armand , CYANAM, Dinesh , KHAZANOV, Nikolay
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/156
Abstract: The disclosure provides gene fusion variants and novel associations with disease states, as well as kits, probes, and methods of using the same.
Abstract translation: 本公开提供了基因融合变体和与疾病状态的新型关联，以及试剂盒，探针和使用它们的方法。
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公开(公告)号：EP2981621B1
公开(公告)日：2019-05-22
申请号：EP14722494.3
申请日：2014-04-03
Applicant: Life Technologies Corporation
Inventor： RHODES, Daniel , SADIS, Seth , WYNGAARD, Peter , BANKHEAD, Armand , CYANAM, Dinesh , KHAZANOV, Nikolay
IPC: C12Q1/6886
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公开(公告)号：EP3438288A1
公开(公告)日：2019-02-06
申请号：EP18189042.7
申请日：2015-03-27
Applicant: Life Technologies Corporation
Inventor： RHODES, Daniel , SADIS, Seth , WYNGAARD, Peter , KHAZANOV, Nikolay , BANDLA, Santhoshi , TOMILO, Mark , EDDY, Sean , BOWDEN, Emma , LI, Jia
IPC: C12Q1/68
Abstract: The present invention relates generally to gene fusions and gene variants that are associated with cancer.
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