公开(公告)号：EP1196167A4

公开(公告)日：2003-05-02

申请号：EP00948576

申请日：2000-06-30

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: C07D401/04 ,  A61K31/00 ,  A61K31/424 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/00 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P27/06 ,  A61P39/02 ,  A61P43/00 ,  C07D401/14 ,  C07D413/04 ,  C07D471/04 ,  C07D513/04 ,  A61K31/40 ,  A61K31/415

CPC classification number: A61K31/506 ,  A61K31/00 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545

Abstract: The invention relates to a method of reducing neuronal injury or apoptosis including administering to a patient in need thereof an effective amount of a p38 mitogen-activated protein kinase (MAPK) inhibitor. Methods of treating an HIV-mediated dementia, glaucoma, or other neurodegenerative disorders are also disclosed.

Abstract translation: 本发明涉及一种减少神经元损伤或凋亡的方法，包括向有需要的患者施用有效量的p38丝裂原活化蛋白激酶（MAPK）抑制剂。 还公开了治疗HIV介导的痴呆，青光眼或其它神经变性疾病的方法。

公开(公告)号：CA2373883A1

公开(公告)日：2001-01-11

申请号：CA2373883

申请日：2000-06-30

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: C07D401/04 ,  A61K31/00 ,  A61K31/424 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/00 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P27/06 ,  A61P39/02 ,  A61P43/00 ,  C07D401/14 ,  C07D413/04 ,  C07D471/04 ,  C07D513/04 ,  A61K31/40 ,  A61K31/415 ,  A61K31/44

Abstract: The invention relates to a method of reducing neuronal injury or apoptosis including administering to a patient in need thereof an effective amount of a p38 mitogen-activated protein kinase (MAPK) inhibitor. Methods of treating a n HIV-mediated dementia, glaucoma, or other neurodegenerative disorders are al so disclosed.

公开(公告)号：ES3015758T3

公开(公告)日：2025-05-07

申请号：ES18841846

申请日：2018-07-31

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: A61K31/135 ,  A61K31/165 ,  A61K45/06 ,  A61P25/00 ,  G01N33/50 ,  G01N33/53 ,  H04R25/00

公开(公告)号：AU2018309710A1

公开(公告)日：2020-02-27

申请号：AU2018309710

申请日：2018-07-31

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: A61K31/135 ,  A61K31/165 ,  A61K45/06 ,  G01N33/50 ,  G01N33/53 ,  H04R25/00

Abstract: Disclosed herein are methods for treating juvenile onset neurological conditions, such as autism (ASD), intellectual disability, or epilepsy, with an inhibitor of N-methyl-D-aspartate receptor (NMDAR). The inhibitor may be NitroSynapsin or a derivative thereof.

公开(公告)号：DE60027431D1

公开(公告)日：2006-05-24

申请号：DE60027431

申请日：2000-06-30

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: A61K31/40 ,  C07D401/04 ,  A61K31/00 ,  A61K31/415 ,  A61K31/424 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/00 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P27/06 ,  A61P39/02 ,  A61P43/00 ,  C07D401/14 ,  C07D413/04 ,  C07D471/04 ,  C07D513/04

Abstract: The invention relates to a method of reducing neuronal injury or apoptosis including administering to a patient in need thereof an effective amount of a p38 mitogen-activated protein kinase (MAPK) inhibitor. Methods of treating an HIV-mediated dementia, glaucoma, or other neurodegenerative disorders are also disclosed.

公开(公告)号：AT323482T

公开(公告)日：2006-05-15

申请号：AT00948576

申请日：2000-06-30

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: C07D401/04 ,  A61K31/00 ,  A61K31/424 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/00 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P27/06 ,  A61P39/02 ,  A61P43/00 ,  C07D401/14 ,  C07D413/04 ,  C07D471/04 ,  C07D513/04 ,  A61K31/40 ,  A61K31/415

Abstract: The invention relates to a method of reducing neuronal injury or apoptosis including administering to a patient in need thereof an effective amount of a p38 mitogen-activated protein kinase (MAPK) inhibitor. Methods of treating an HIV-mediated dementia, glaucoma, or other neurodegenerative disorders are also disclosed.

公开(公告)号：AU777275B2

公开(公告)日：2004-10-07

申请号：AU6205200

申请日：2000-06-30

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: C07D401/04 ,  A61K31/00 ,  A61K31/424 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/00 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P27/06 ,  A61P39/02 ,  A61P43/00 ,  C07D401/14 ,  C07D413/04 ,  C07D471/04 ,  C07D513/04 ,  A61K31/40 ,  A61K31/415 ,  A61K31/44

Abstract: The invention relates to a method of reducing neuronal injury or apoptosis including administering to a patient in need thereof an effective amount of a p38 mitogen-activated protein kinase (MAPK) inhibitor. Methods of treating an HIV-mediated dementia, glaucoma, or other neurodegenerative disorders are also disclosed.

公开(公告)号：CA3071541A1

公开(公告)日：2019-02-07

申请号：CA3071541

申请日：2018-07-31

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: A61K31/135 ,  A61K31/165 ,  A61K45/06 ,  G01N33/50 ,  G01N33/53 ,  H04R25/00

Abstract: Disclosed herein are methods for treating juvenile onset neurological conditions, such as autism (ASD), intellectual disability, or epilepsy, with an inhibitor of N-methyl-D-aspartate receptor (NMDAR). The inhibitor may be NitroSynapsin or a derivative thereof.

公开(公告)号：DE60027431T2

公开(公告)日：2007-07-12

申请号：DE60027431

申请日：2000-06-30

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: A61K31/40 ,  C07D401/04 ,  A61K31/00 ,  A61K31/415 ,  A61K31/424 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K45/00 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P27/06 ,  A61P39/02 ,  A61P43/00 ,  C07D401/14 ,  C07D413/04 ,  C07D471/04 ,  C07D513/04

Abstract: The invention relates to a method of reducing neuronal injury or apoptosis including administering to a patient in need thereof an effective amount of a p38 mitogen-activated protein kinase (MAPK) inhibitor. Methods of treating an HIV-mediated dementia, glaucoma, or other neurodegenerative disorders are also disclosed.

公开(公告)号：ES2260033T3

公开(公告)日：2006-11-01

申请号：ES00948576

申请日：2000-06-30

Applicant: LIPTON STUART A

Inventor： LIPTON STUART A

IPC: A61K31/00 ,  A61K31/424 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  C07D401/04 ,  A61K45/00 ,  A61P3/08 ,  A61P3/10 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P27/06 ,  A61P39/02 ,  A61P43/00 ,  C07D401/14 ,  C07D413/04 ,  C07D471/04 ,  C07D513/04 ,  A61K31/40 ,  A61K31/415

Abstract: El uso de un inhibidor de la proteína quinasa activada por mitógenos (MAPK) p38 en la fabricación de un medicamento para el tratamiento de pacientes que sufren glaucoma, neuropatía óptica, neuritis óptica, isquemia retinal, lesiones ópticas inducidas por láser, o vitreoretinopatía proliferativa inducida por cirugía o trauma; un paciente que sufre lesión neuronal o apoptosis que implique las células ganglionares de la retina; o un paciente que sufra un estado médico que provoque estrés nitrosativo u oxidativo a las células ganglionares de la retina por la activación excesiva de receptores aminoácidos excitatorios o la generación de radicales libres.