公开(公告)号：CA2481299A1

公开(公告)日：2003-10-23

申请号：CA2481299

申请日：2003-04-02

Applicant: MDS INC DBA MDS SCIEX

Inventor： LONDRY FRANK ,  COLLINGS BRUCE A ,  STOTT WILLIAM R

IPC: H01J49/42

Abstract: In the field of mass spectrometry, a method and apparatus for fragmenting io ns with a relatively high degree of resolution. The technique includes trapping the ions in an ion trap, preferably a linear ion trap, in which the backgrou nd or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1V(0- pk). The technique allows selective dissociation of ions with a discriminati on of at least about 1 m/z at a practical fragmentation efficiencies. Apparatus and related methods are also disclosed for obtaining MS, MS2, MS3 and MSn spectrums at relatively high resolutions using the low pressure fragmentatio n technique.

公开(公告)号：CA2483542C

公开(公告)日：2012-10-16

申请号：CA2483542

申请日：2003-04-02

Applicant: MDS INC DBA MDS SCIEX

Inventor： COLLINGS BRUCE A ,  HAGER JAMES ,  LONDRY FRANK ,  STOTT WILLIAM R

IPC: G01N27/62 ,  H01J49/42

Abstract: An improved method of operating a mass spectrometer having a linear ion trap wherein ions are axially ejected from the trap to a detector or subsequent mass analysis stage. The DC barrier field produced at the exit lens of the trap is scanned in conjunction with the scanning of other fields used to energize ions of select mass-to-charge ratios past the barrier field/exit lens. The technique can maximize the resolution obtainable from axial ejection over a wide mass range.

公开(公告)号：CA2481081C

公开(公告)日：2012-01-10

申请号：CA2481081

申请日：2003-04-02

Applicant: MDS INC DBA MDS SCIEX ,  APPLERA CORP

Inventor： LONDRY FRANK ,  COLLINGS BRUCE A ,  STOTT WILIAM R

IPC: G01N27/62 ,  H01J49/42 ,  H01J49/00

Abstract: In the field of mass spectrometry, a method and apparatus for fragmenting ions with a relatively high degree of resolution and efficiency. The technique includes trapping the ions in a linear ion trap, in which the background or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1 Volt (0-pk). The technique allows selective dissociation of ions with a high discrimination. High fragmentation efficiency may be achieved by superimposing a higher order multipole field onto the quadrupolar RF field used to trap the ions. The multipole field, preferably an octopole field, dampens the radial oscillatory motion of resonantly excited ions at the periphery of the trap. This reduces the probability that ions will eject radially from the trap thus increasing the probability of collision induced dissociation.

公开(公告)号：AT345578T

公开(公告)日：2006-12-15

申请号：AT03724745

申请日：2003-05-29

Applicant: MDS INC DBA MDS SCIEX

Inventor： LONDRY FRANK ,  STOTT WILLIAM R ,  COLLINGS BRUCE A ,  HAGER JAMES

IPC: G01N27/62 ,  H01J49/42

Abstract: The invention solves the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rods. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. The third approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.

公开(公告)号：CA2539221A1

公开(公告)日：2005-03-31

申请号：CA2539221

申请日：2004-09-01

Applicant: MDS INC DBA MDS SCIEX

Inventor： DING CHUAN-FAN ,  DOUGLAS DONALD J ,  LONDRY FRANK

IPC: H01J49/42 ,  G21K1/08 ,  H01J3/26 ,  H01J49/00

Abstract: A method and apparatus for manipulating ions using a two~ dimensional substantially quadrupole field, and a method of manufacturing and operating an apparatus for manipulating ions using a two-dimensional substantially quadrupole field are described. The field has a quadrupole harmonic with amplitude A2 and a hexapole harmonic with amplitude A3. The amplitude A3 of the hexapole component of the field is selected to improve the performance o f the field with respect to ion selection and ion fragmentation.

公开(公告)号：AU2003229212A8

公开(公告)日：2003-12-19

申请号：AU2003229212

申请日：2003-05-29

Applicant: MDS INC DBA MDS SCIEX

Inventor： COLLINGS BRUCE A ,  STOTT WILLIAM R ,  LONDRY FRANK ,  HAGER JAMES

IPC: G01N27/62 ,  H01J49/42

Abstract: The invention solves the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rods. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. The third approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.

公开(公告)号：CA2483542A1

公开(公告)日：2003-12-11

申请号：CA2483542

申请日：2003-04-02

Applicant: MDS INC DBA MDS SCIEX

Inventor： LONDRY FRANK ,  COLLINGS BRUCE A ,  HAGER JAMES ,  STOTT WILLIAM R

IPC: G01N27/62 ,  H01J49/42

Abstract: An improved method of operating a mass spectrometer having a linear ion trap wherein ions are axially ejected from the trap to a detector or subsequent mass analysis stage. The DC barrier field produced at the exit lens of the trap is scanned in conjunction with the scanning of other fields used to energize ions of select mass-to-charge ratios past the barrier field/exit lens. The technique can maximize the resolution obtainable from axial ejecti on over a wide mass range.

公开(公告)号：CA2485894C

公开(公告)日：2012-10-30

申请号：CA2485894

申请日：2003-05-29

Applicant: MDS INC DBA MDS SCIEX

Inventor： LONDRY FRANK ,  STOTT WILLIAM R ,  COLLINGS BRUCE A ,  HAGER JAMES W

IPC: G01N27/62 ,  H01J49/42

Abstract: The invention addresses the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rods. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. Another approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.

公开(公告)号：CA2608972A1

公开(公告)日：2006-11-23

申请号：CA2608972

申请日：2006-05-17

Applicant: APPLERA CORP ,  MDS INC DBA MDS SCIEX

Inventor： JOLLIFFE CHARLES L ,  LOBODA ALEXANDRE V ,  LONDRY FRANK

IPC: H01J49/42

Abstract: A mass spectrometer system and a method of operating a mass spectrometer are provided. An RF field is produced between the plurality of rods to radially confine the ions in the rod set. The RF field has a resolving DC component field. The resolving DC component field is varied along at least a portion of a length of the rod set to provide a DC axial force acting on the ions.

公开(公告)号：AU2003229212A1

公开(公告)日：2003-12-19

申请号：AU2003229212

申请日：2003-05-29

Applicant: MDS INC DBA MDS SCIEX

Inventor： STOTT WILLIAM R ,  COLLINGS BRUCE A ,  HAGER JAMES ,  LONDRY FRANK

IPC: G01N27/62 ,  H01J49/42

Abstract: The invention solves the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rods. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. The third approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.