公开(公告)号：CA2481299A1

公开(公告)日：2003-10-23

申请号：CA2481299

申请日：2003-04-02

Applicant: MDS INC DBA MDS SCIEX

Inventor： LONDRY FRANK ,  COLLINGS BRUCE A ,  STOTT WILLIAM R

IPC: H01J49/42

Abstract: In the field of mass spectrometry, a method and apparatus for fragmenting io ns with a relatively high degree of resolution. The technique includes trapping the ions in an ion trap, preferably a linear ion trap, in which the backgrou nd or neutral gas pressure is preferably on the order of 10-5 Torr. The trapped ions are resonantly excited for a relatively extended period of time, e.g., exceeding 50 ms, at relatively low excitation levels, e.g., less than 1V(0- pk). The technique allows selective dissociation of ions with a discriminati on of at least about 1 m/z at a practical fragmentation efficiencies. Apparatus and related methods are also disclosed for obtaining MS, MS2, MS3 and MSn spectrums at relatively high resolutions using the low pressure fragmentatio n technique.

公开(公告)号：CA2483542A1

公开(公告)日：2003-12-11

申请号：CA2483542

申请日：2003-04-02

Applicant: MDS INC DBA MDS SCIEX

Inventor： LONDRY FRANK ,  COLLINGS BRUCE A ,  HAGER JAMES ,  STOTT WILLIAM R

IPC: G01N27/62 ,  H01J49/42

Abstract: An improved method of operating a mass spectrometer having a linear ion trap wherein ions are axially ejected from the trap to a detector or subsequent mass analysis stage. The DC barrier field produced at the exit lens of the trap is scanned in conjunction with the scanning of other fields used to energize ions of select mass-to-charge ratios past the barrier field/exit lens. The technique can maximize the resolution obtainable from axial ejecti on over a wide mass range.

公开(公告)号：AU2003229212A8

公开(公告)日：2003-12-19

申请号：AU2003229212

申请日：2003-05-29

Applicant: MDS INC DBA MDS SCIEX

Inventor： COLLINGS BRUCE A ,  STOTT WILLIAM R ,  LONDRY FRANK ,  HAGER JAMES

IPC: G01N27/62 ,  H01J49/42

Abstract: The invention solves the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rods. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. The third approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.

公开(公告)号：CA2483542C

公开(公告)日：2012-10-16

申请号：CA2483542

申请日：2003-04-02

Applicant: MDS INC DBA MDS SCIEX

Inventor： COLLINGS BRUCE A ,  HAGER JAMES ,  LONDRY FRANK ,  STOTT WILLIAM R

IPC: G01N27/62 ,  H01J49/42

Abstract: An improved method of operating a mass spectrometer having a linear ion trap wherein ions are axially ejected from the trap to a detector or subsequent mass analysis stage. The DC barrier field produced at the exit lens of the trap is scanned in conjunction with the scanning of other fields used to energize ions of select mass-to-charge ratios past the barrier field/exit lens. The technique can maximize the resolution obtainable from axial ejection over a wide mass range.

公开(公告)号：AT345578T

公开(公告)日：2006-12-15

申请号：AT03724745

申请日：2003-05-29

Applicant: MDS INC DBA MDS SCIEX

Inventor： LONDRY FRANK ,  STOTT WILLIAM R ,  COLLINGS BRUCE A ,  HAGER JAMES

IPC: G01N27/62 ,  H01J49/42

Abstract: The invention solves the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rods. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. The third approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.

公开(公告)号：CA2485894C

公开(公告)日：2012-10-30

申请号：CA2485894

申请日：2003-05-29

Applicant: MDS INC DBA MDS SCIEX

Inventor： LONDRY FRANK ,  STOTT WILLIAM R ,  COLLINGS BRUCE A ,  HAGER JAMES W

IPC: G01N27/62 ,  H01J49/42

Abstract: The invention addresses the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rods. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. Another approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.

公开(公告)号：AU2003229212A1

公开(公告)日：2003-12-19

申请号：AU2003229212

申请日：2003-05-29

Applicant: MDS INC DBA MDS SCIEX

Inventor： STOTT WILLIAM R ,  COLLINGS BRUCE A ,  HAGER JAMES ,  LONDRY FRANK

IPC: G01N27/62 ,  H01J49/42

Abstract: The invention solves the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rods. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. The third approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.

公开(公告)号：AU2003213944A1

公开(公告)日：2003-12-19

申请号：AU2003213944

申请日：2003-04-02

Applicant: MDS INC DBA MDS SCIEX

Inventor： LONDRY FRANK ,  HAGER JAMES ,  STOTT WILLIAM R ,  COLLINGS BRUCE A

IPC: G01N27/62 ,  H01J49/42

公开(公告)号：CA2485894A1

公开(公告)日：2003-12-11

申请号：CA2485894

申请日：2003-05-29

Applicant: MDS INC DBA MDS SCIEX

Inventor： STOTT WILLIAM R ,  LONDRY FRANK ,  HAGER JAMES W ,  COLLINGS BRUCE A

IPC: G01N27/62 ,  H01J49/42

Abstract: The invention addresses the problem of artifact ghost peaks which can sometimes arise in mass spectrometers that employ a quadrupole rod set for both trapping and mass analyzing the trapped ions. The problem arises as a result of randomly distributed voltage gradients along the length of the rod s. Three solutions are presented. The first approach involves improving the conduction characteristics of the rod sets. The second approach involves the application of at least one continuous axial DC field to the trapping quadrupole rod set in order to urge ions towards a pre-determined region of the trap, thereby avoiding voltage gradients. Another approach involves the application of one or more discrete axial fields to create one or more potential barriers along the axial dimension of the trap (in addition to the barriers used to initially trap the ions). These barriers prevent ions of differing voltage gradients from equilibrating with one another.