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    Optical microprobe and spectral analysis method of material
    1.
    发明专利
    Optical microprobe and spectral analysis method of material 审中-公开
    光学微波和光谱分析方法

    公开(公告)号：JP2006138860A

    公开(公告)日：2006-06-01

    申请号：JP2005345332

    申请日：2005-11-30

    Applicant: Medispectra Inc ,  メディスペクトラ・インコーポレーテッドMedispectra,Inc.

    Inventor： MODELL MARK ,  DEBARYSHE GREGORY ,  HED A ZE EV

    IPC: G01N21/27 ,  G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/47

    CPC classification number: A61B5/0084 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  G01N21/4795

    Abstract: PROBLEM TO BE SOLVED: To provide a method and a device for analyzing samples by spatially limiting responses observed in a small volume element. SOLUTION: This device includes: a radiating section 12 for generating radiation; a 1st light-limiting section 14; and a directivity (objective) optical system 16 (these are collectively referred to as "irradiation optical systems"), where the beam that has passed through the light-limiting section and formed will be irradiated on a sample 18. A collecting optical system 20 collects and detects radiation from the irradiated sample 18, which will pass through the 2nd light-limiting section 22. The device also includes a limiting section 26, connected to the irradiation and collecting optical system or its part, to adjust the position where the radiation has been directed, and collecting responses from selected volume elements. COPYRIGHT: (C)2006,JPO&NCIPI

    Abstract translation: 要解决的问题：提供用于通过空间限制在小体积元件中观察到的响应来分析样品的方法和装置。 解决方案：该装置包括：用于产生辐射的辐射部分12; 第一限光部分14; 以及定向性（物镜）光学系统16（这些统称为“照射光学系统”），其中已经通过限定部分并形成的光束将照射在样本18上。收集光学系统20 收集和检测来自被照射的样品18的辐射，其将通过第二限光部分22.该装置还包括限制部分26，其连接到照射和收集光学系统或其部分，以调节放射线 已被引导，并收集所选卷元素的响应。 版权所有（C）2006，JPO＆NCIPI

    SPATIALLY RESOLVED OPTICAL MEASUREMENTS
    4.
    发明专利
    SPATIALLY RESOLVED OPTICAL MEASUREMENTS 未知

    公开(公告)号：CA2277095C

    公开(公告)日：2003-09-16

    申请号：CA2277095

    申请日：1998-01-09

    Applicant: MEDISPECTRA INC

    Inventor： MODELL MARK ,  HED A ZE EV

    IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B10/00 ,  G01N21/27 ,  G01N21/47

    Abstract: Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with th e sample. The apparatus includes a source of electromagnetic radiation, an optical assembly and a detector. The optical assembly sequentially illuminat es a plurality of volume elements in the sample with an intensity distribution in the sample that drops off substantially monotonically from a first region in a first optical path and collects electromagnetic radiation emanating from eac h of the volume elements. The optical assembly collects the electromagnetic radiation emanating from each of the volume elements with a collected distribution that drops off substantially monotonically from a second region in a second optical path. The first and second regions at least partially overlap in each of the volume elements. The detector detects the collected electromagnetic radiation emanating from each of the sequentially illuminate d volume elements to produce responses representative of the characteristic in each of the volume elements.

    Optical methods and systems for cervical screening
    5.
    发明专利
    Optical methods and systems for cervical screening 未知

    公开(公告)号：AU760402B2

    公开(公告)日：2003-05-15

    申请号：AU2959600

    申请日：1999-12-23

    Applicant: MEDISPECTRA INC

    Inventor： NORDSTROM ROBERT ,  MODELL MARK

    IPC: G01N21/64 ,  A61B5/00 ,  A61B10/00 ,  G01N21/27 ,  G01N21/35

    Abstract: A method and a system is provided for discriminating between healthy cervical tissue and pathologic cervical tissue based on the fluorescence response of the tissue to laser excitation (LIF) and the backscatter response to illumination by white light (in the spectral range of 360 to 750 nm). Combining LIF and white light responses, as well as evaluating a spatial correlation between proximate cervical tissue sites in conjunction with a statistically significant "distance" algorithm, such as the Mahalanobis distance between data sets, can improve the discrimination between normal and abnormal tissue. The results may be displayed in the form of a map of the cervix representing the suspected pathology.

    6.
    发明专利
    未知

    公开(公告)号：ES2192320T3

    公开(公告)日：2003-10-01

    申请号：ES98903435

    申请日：1998-01-09

    Applicant: MEDISPECTRA INC

    Inventor： MODELL MARK ,  HED A ZE EV

    IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B10/00 ,  G01N21/27 ,  G01N21/47

    Abstract: A method for compiling data characteristic of a sample of material, comprising the steps of: sequentially illuminating, with an optical assembly, a plurality of volume elements in said sample by directing electromagnetic radiation into said sample; sequentially collecting, with said optical assembly, electromagnetic radiation emanating from each of said sequentially illuminated volume elements, said optical assembly comprising at least one array of field stops whose dimensions are large compared to a quotient of wavelength of said electromagnetic radiation divided by a working numerical aperture of said optical assembly, measured from said field stops; and detecting the collected electromagnetic radiation emanating from each of said sequentially illuminated volume elements to produce a response representative of said characteristic in each of said volume elements.

    Optical methods and systems for cervical screening
    9.
    发明专利
    Optical methods and systems for cervical screening 未知

    公开(公告)号：AU2959600A

    公开(公告)日：2000-07-12

    申请号：AU2959600

    申请日：1999-12-23

    Applicant: MEDISPECTRA INC

    Inventor： NORDSTROM ROBERT ,  MODELL MARK

    IPC: G01N21/64 ,  A61B5/00 ,  A61B10/00 ,  G01N21/27 ,  G01N21/35

    Abstract: A method and a system is provided for discriminating between healthy cervical tissue and pathologic cervical tissue based on the fluorescence response of the tissue to laser excitation (LIF) and the backscatter response to illumination by white light (in the spectral range of 360 to 750 nm). Combining LIF and white light responses, as well as evaluating a spatial correlation between proximate cervical tissue sites in conjunction with a statistically significant "distance" algorithm, such as the Mahalanobis distance between data sets, can improve the discrimination between normal and abnormal tissue. The results may be displayed in the form of a map of the cervix representing the suspected pathology.

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