公开(公告)号：JP2006138860A

公开(公告)日：2006-06-01

申请号：JP2005345332

申请日：2005-11-30

Applicant: Medispectra Inc ,  メディスペクトラ・インコーポレーテッドMedispectra,Inc.

Inventor： MODELL MARK ,  DEBARYSHE GREGORY ,  HED A ZE EV

IPC: G01N21/27 ,  G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  G01N21/47

CPC classification number: A61B5/0084 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  G01N21/4795

Abstract: PROBLEM TO BE SOLVED: To provide a method and a device for analyzing samples by spatially limiting responses observed in a small volume element. SOLUTION: This device includes: a radiating section 12 for generating radiation; a 1st light-limiting section 14; and a directivity (objective) optical system 16 (these are collectively referred to as "irradiation optical systems"), where the beam that has passed through the light-limiting section and formed will be irradiated on a sample 18. A collecting optical system 20 collects and detects radiation from the irradiated sample 18, which will pass through the 2nd light-limiting section 22. The device also includes a limiting section 26, connected to the irradiation and collecting optical system or its part, to adjust the position where the radiation has been directed, and collecting responses from selected volume elements. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供用于通过空间限制在小体积元件中观察到的响应来分析样品的方法和装置。 解决方案：该装置包括：用于产生辐射的辐射部分12; 第一限光部分14; 以及定向性（物镜）光学系统16（这些统称为“照射光学系统”），其中已经通过限定部分并形成的光束将照射在样本18上。收集光学系统20 收集和检测来自被照射的样品18的辐射，其将通过第二限光部分22.该装置还包括限制部分26，其连接到照射和收集光学系统或其部分，以调节放射线 已被引导，并收集所选卷元素的响应。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：ES2192320T3

公开(公告)日：2003-10-01

申请号：ES98903435

申请日：1998-01-09

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B10/00 ,  G01N21/27 ,  G01N21/47

Abstract: A method for compiling data characteristic of a sample of material, comprising the steps of: sequentially illuminating, with an optical assembly, a plurality of volume elements in said sample by directing electromagnetic radiation into said sample; sequentially collecting, with said optical assembly, electromagnetic radiation emanating from each of said sequentially illuminated volume elements, said optical assembly comprising at least one array of field stops whose dimensions are large compared to a quotient of wavelength of said electromagnetic radiation divided by a working numerical aperture of said optical assembly, measured from said field stops; and detecting the collected electromagnetic radiation emanating from each of said sequentially illuminated volume elements to produce a response representative of said characteristic in each of said volume elements.

公开(公告)号：CA2277095C

公开(公告)日：2003-09-16

申请号：CA2277095

申请日：1998-01-09

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B10/00 ,  G01N21/27 ,  G01N21/47

Abstract: Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with th e sample. The apparatus includes a source of electromagnetic radiation, an optical assembly and a detector. The optical assembly sequentially illuminat es a plurality of volume elements in the sample with an intensity distribution in the sample that drops off substantially monotonically from a first region in a first optical path and collects electromagnetic radiation emanating from eac h of the volume elements. The optical assembly collects the electromagnetic radiation emanating from each of the volume elements with a collected distribution that drops off substantially monotonically from a second region in a second optical path. The first and second regions at least partially overlap in each of the volume elements. The detector detects the collected electromagnetic radiation emanating from each of the sequentially illuminate d volume elements to produce responses representative of the characteristic in each of the volume elements.

公开(公告)号：MX9800874A

公开(公告)日：1998-09-30

申请号：MX9800874

申请日：1998-01-30

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  DEBARYSHE GREGORY ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/47 ,  A61B05/00

Abstract: Una sonda optica recolecta luz que emana de un espécimen que representa en forma selectiva y preferencial un elemento de volumen localizado dentro de una muestra, con intensidad de iluminacion y eficacia de recoleccion que se retiran ambas del elemento de volumen localizado, para limitar la contribucion integrada desde fuera del elemento. Por ejemplo, los componentes opticos proporcionan alta iluminacion de pico y alta eficiencia de recoleccion, que ambas se traslapan en elementos de volumen de un tamaño limitado que corresponde a una estructura o proceso del espécimen. La señal recolectada resultante comprende uno o más segmentos espectrales se correlaciona altamente con características opticas tales como absorbencia, dispersion o características de fluorescencia del material en pequeños elementos de volumen. Un procesador puede aplicar una transformada de matriz o vector previamente derivado a las respuestas recolectadas, para producir una salida. Los espectros recolectados u otras respuestas tienen alta intensidad de señal y representan efectos opticos pequeños o de otra forma inaccesibles o enmascarados presentes en la muestra, de manera tal que se correlacionen fácilmente a condiciones de interés.

公开(公告)号：AT236388T

公开(公告)日：2003-04-15

申请号：AT98903435

申请日：1998-01-09

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B10/00 ,  G01N21/27 ,  G01N21/47

Abstract: A method for compiling data characteristic of a sample of material, comprising the steps of: sequentially illuminating, with an optical assembly, a plurality of volume elements in said sample by directing electromagnetic radiation into said sample; sequentially collecting, with said optical assembly, electromagnetic radiation emanating from each of said sequentially illuminated volume elements, said optical assembly comprising at least one array of field stops whose dimensions are large compared to a quotient of wavelength of said electromagnetic radiation divided by a working numerical aperture of said optical assembly, measured from said field stops; and detecting the collected electromagnetic radiation emanating from each of said sequentially illuminated volume elements to produce a response representative of said characteristic in each of said volume elements.

公开(公告)号：CA2277095A1

公开(公告)日：1998-07-16

申请号：CA2277095

申请日：1998-01-09

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B10/00 ,  G01N21/27 ,  G01N21/47

Abstract: Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes a source of electromagnetic radiation, an optical assembly and a detector. The optical assembly sequentially illuminates a plurality of volume elements in the sample with an intensity distribution in the sample that drops off substantially monotonically from a first region in a first optical path and collects electromagnetic radiation emanating from each of the volume elements. The optical assembly collects the electromagnetic radiation emanating from each of the volume elements with a collected distribution that drops off substantially monotonically from a second region in a second optical path. The first and second regions at least partially overlap in each of the volume elements. The detector detects the collected electromagnetic radiation emanating from each of the sequentially illuminated volume elements to produce responses representative of the characteristic in each of the volume elements.

公开(公告)号：AU6645796A

公开(公告)日：1997-02-26

申请号：AU6645796

申请日：1996-08-01

Applicant: MEDISPECTRA INC

Inventor： MODELL MARK ,  DEBARYSHE GREGORY ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/47

公开(公告)号：CA2228308A1

公开(公告)日：1997-02-13

申请号：CA2228308

申请日：1996-08-01

Applicant: MEDISPECTRA INC

Inventor： DEBARYSHE GREGORY ,  MODELL MARK ,  HED A ZE EV

IPC: G01N21/64 ,  A61B1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/47 ,  G01N21/00 ,  A61B10/00

Abstract: An optical probe collects light emanating from a specimen that selectively and preferentially represents a localized volume element within the sample, with illumination intensity and collection efficacy both dropping off away from the localized volume element to limit the integrated contribution from outside the element. For example, the optics provide high peak illumination and high collection efficiency which both overlap in volume elements of a limited size corresponding to a structure or process of the specimen. The resulting collected signal comprising one or more spectral segments is highly correlated with optical characteristics, such as absorbance, scattering or fluorescence characteristics of material in the small volume elements. A processor may apply a previously-derived vector or matrix transform to the collected responses to produce an output. The collected spectra or other responses have high signal strength and represent small or otherwise inaccessible or masked optical effects present in the sample, so that they are readily correlated to conditions of interest.