公开(公告)号：JPS6345561A

公开(公告)日：1988-02-26

申请号：JP18021687

申请日：1987-07-21

Applicant: MILES LAB

Inventor： ALBARELLA JAMES P ,  BUCKLER ROBERT T

IPC: C12Q1/00 ,  C12Q1/34 ,  C12Q1/68 ,  G01N33/535

公开(公告)号：FI871450A

公开(公告)日：1987-10-05

申请号：FI871450

申请日：1987-04-02

Applicant: MILES LAB

Inventor： ALBARELLA JAMES P ,  CHARLTON STEVEN C ,  REINSCH JAMES W ,  WARCHAL MARY ELLEN

IPC: C12Q1/00 ,  C12Q1/26 ,  C12Q1/54 ,  G01N31/22 ,  G01N33/52 ,  G01N33/66 ,  C12Q

公开(公告)号：DK171087A

公开(公告)日：1987-10-05

申请号：DK171087

申请日：1987-04-03

Applicant: MILES LAB

Inventor： ALBARELLA JAMES P ,  CHARLTON STEVEN C ,  REINSCH JAMES W ,  WARCHAL MARY ELLEN

IPC: C12Q1/00 ,  C12Q1/26 ,  C12Q1/54 ,  G01N31/22 ,  G01N33/52 ,  G01N33/66

公开(公告)号：DK171687D0

公开(公告)日：1987-04-03

申请号：DK171687

申请日：1987-04-03

Applicant: MILES LAB

Inventor： ALBARELLA JAMES P ,  CHARLTON STEVEN C ,  REINSCH JAMES W ,  WARCHAL MARY ELLEN

IPC: C12Q1/00 ,  C12Q1/54 ,  G01N31/22 ,  G01N33/52 ,  G01N33/66

Abstract: Test compositions and test devices are provided which are capable of generating different hues at different analyte concentrations. Visual results for clinically important analytes, such as glucose and cholesterol, are provided by use of compositions containing two independent catalytic systems which are reactive with a common substrate generated from the analyte of interest, to produce visual endpoints of different hues for different concentrations of analyte. Preferred formulations provide a RAINBOW of hues, the particular final hue produced depending on the concentration of the analyte.

公开(公告)号：DK591984A

公开(公告)日：1985-06-13

申请号：DK591984

申请日：1984-12-11

Applicant: MILES LAB

Inventor： ALBARELLA JAMES P ,  ANDERSON LESLIE H ,  CARRICO ROBERT J

IPC: C07K16/18 ,  C12Q1/68 ,  C12Q1/70 ,  G01N ,  C12Q

公开(公告)号：DK591484A

公开(公告)日：1985-06-13

申请号：DK591484

申请日：1984-12-11

Applicant: MILES LAB

Inventor： ALBARELLA JAMES P ,  ANDERSON LESLIE H ,  CARRICO ROBERT J

IPC: C07K16/18 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/542 ,  C12Q ,  G01N

公开(公告)号：FI844867A0

公开(公告)日：1984-12-10

申请号：FI844867

申请日：1984-12-10

Applicant: MILES LAB

Inventor： ALBARELLA JAMES P ,  ANDERSON LESLIE H ,  CARRICO ROBERT J

IPC: C07K16/18 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/542 ,  C12N

公开(公告)号：CA1293441C

公开(公告)日：1991-12-24

申请号：CA535409

申请日：1987-04-23

Applicant: MILES LAB

Inventor： ALBARELLA JAMES P ,  BUCKLER ROBERT T

IPC: C12Q1/00 ,  C12Q1/34 ,  C12Q1/68 ,  G01N33/535 ,  G01N33/53 ,  G01N33/563

Abstract: Enzyme-labeled antibody reagents wherein the enzyme and an antibody reagent, e.g., whole polyclonal or monoclonal antibody or a fragment thereof, are covalently linked through a bis-maleimidopolyalkyleneglycol bridge group. The reagents are useful in immunoassay and other methods for detecting an antigen or hapten that can be bound by the antibody reagent. The conjugates are highly stable and water soluble, and are characterized by a high degree of immunoreactivity and enzyme activity.

公开(公告)号：AU7103487A

公开(公告)日：1987-10-08

申请号：AU7103487

申请日：1987-04-03

Applicant: MILES LAB

Inventor： ALBARELLA JAMES P ,  CHARLTON STEVEN C ,  REINSCH JAMES W ,  WARCHAL MARY ELLEN

IPC: C12Q1/00 ,  C12Q1/54 ,  G01N31/22 ,  G01N33/52 ,  G01N33/66

Abstract: Test compositions and test devices are provided which are capable of generating different hues at different analyte concentrations. Visual results for clinically important analytes, such as glucose and cholesterol, are provided by use of compositions containing two independent catalytic systems which are reactive with a common substrate generated from the analyte of interest, to produce visual endpoints of different hues for different concentrations of analyte. Preferred formulations provide a RAINBOW of hues, the particular final hue produced depending on the concentration of the analyte.

公开(公告)号：FI871449A

公开(公告)日：1987-10-05

申请号：FI871449

申请日：1987-04-02

Applicant: MILES LAB

Inventor： ALBARELLA JAMES P ,  CHARLTON STEVEN C ,  REINSCH JAMES W ,  WARCHAL MARY ELLEN

IPC: C12Q1/00 ,  C12Q1/54 ,  G01N31/22 ,  G01N33/52 ,  G01N33/66 ,  C12Q

Abstract: Test compositions and test devices are provided which are capable of generating different hues at different analyte concentrations. Visual results for clinically important analytes, such as glucose and cholesterol, are provided by use of compositions containing two independent catalytic systems which are reactive with a common substrate generated from the analyte of interest, to produce visual endpoints of different hues for different concentrations of analyte. Preferred formulations provide a RAINBOW of hues, the particular final hue produced depending on the concentration of the analyte.