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    PROCESS FOR THE PREPARATION OF BINARY INDOLE ALKALOIDS
    4.
    发明专利
    PROCESS FOR THE PREPARATION OF BINARY INDOLE ALKALOIDS 未知

    公开(公告)号：CA2011389A1

    公开(公告)日：1990-09-04

    申请号：CA2011389

    申请日：1990-03-02

    Applicant: MITSUI PETROCHEMICAL IND

    Inventor： SAKAMOTO NAOYA ,  TAN HIROAKI ,  HATA EIICHIROU ,  KIHARA NORIAKI

    IPC: C07D519/04

    Abstract: The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

    PROCESS FOR PRODUCING BINARY INDOLEALKALOIDS
    7.
    发明专利
    PROCESS FOR PRODUCING BINARY INDOLEALKALOIDS 未知

    公开(公告)号：HUT54167A

    公开(公告)日：1991-01-28

    申请号：HU127390

    申请日：1990-03-02

    Applicant: MITSUI PETROCHEMICAL IND

    Inventor： SAKAMOTO NAOYA ,  TAN HIROAKI ,  HATA EIICHIROU ,  KIHARA NORIAKI

    IPC: C07D519/04

    Abstract: The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

    METHOD FOR PRODUCTION OF DIMERIC ALKALOIDS
    9.
    发明专利
    METHOD FOR PRODUCTION OF DIMERIC ALKALOIDS 未知

    公开(公告)号：CA1334588C

    公开(公告)日：1995-02-28

    申请号：CA607984

    申请日：1989-08-10

    Applicant: MITSUI PETROCHEMICAL IND

    Inventor： TAN HIROAKI ,  SAKAMOTO NAOYA ,  HATA EIICHIROU ,  ISHITOKU TAKESHI ,  KIHARA NORIAKI

    IPC: C07D519/04

    Abstract: This invention concerns a method for the production of dimeric alkaloid, characterized by a procedure which comprises causing reaction of catharanthine with vindoline in the presence of Fe3+ and (1) removing or inactivating the Fe3+ and allowing the reaction product to react with a reducing agent or (2) allowing presence of oxygen and a dicarboxylic acid or a derivative thereof in the reaction system and allowing the reaction product to react with a hydride source. In accordance with this invention, such dimeric alkaloid as vinblastine, leurocidin, and 3',4'-anhydrovin-blastine which are useful as antineoplastic drugs can be produced in high yields.

    10.
    发明专利
    未知

    公开(公告)号：DE69002489D1

    公开(公告)日：1993-09-09

    申请号：DE69002489

    申请日：1990-03-05

    Applicant: MITSUI PETROCHEMICAL IND

    Inventor： SAKAMOTO NAOYA ,  TAN HIROAKI ,  HATA EIICHIROU ,  KIHARA NORIAKI

    IPC: C07D519/04

    Abstract: The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

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