公开(公告)号：EP0288582A4

公开(公告)日：1989-06-21

申请号：EP87907350

申请日：1987-11-10

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TANIGUCHI KATSUO ,  TANAKA MICHIO ,  TAKAHATA KAZUNORI ,  SAKAMOTO NAOYA ,  TAKAI TOSHIHIRO ,  KURANO YOSHITO ,  ISHIBASHI MASAYASU

IPC: B01J29/18 ,  B01J29/00 ,  C07B61/00 ,  C07C1/00 ,  C07C2/66 ,  C07C2/86 ,  C07C15/00 ,  C07C15/02 ,  C07C15/14 ,  C07C15/16 ,  C07C15/24 ,  C07C37/08 ,  C07C39/15 ,  C07C43/263 ,  C07C67/00 ,  C07C67/08

CPC classification number: C07C39/15 ,  C07C2/66 ,  C07C2/861 ,  C07C2/864 ,  C07C2529/18 ,  C07C15/00

Abstract: A process for producing alkyl group-substituted aromatic hydrocarbons, which comprises reacting an aromatic hydrocarbon (i) with an alkylating agent (ii) selected from the group consisting of an olefin, an aliphatic lower alcohol, and a alkyl halide in the presence of a mordenite zeolite catalyst treated with a fluorine-containing compound. This process enables raising the conversion of the aromatic compound and introducing a specific number of alkyl groups into specific positions of the aromatic compound. When biphenyl and propylene are used as the aromatic hydrocarbon and the alkylating agent, respectively, p,p'-diisopropylbiphenyl can be obtained in a high yield and a high selectivity.

公开(公告)号：DE68927649D1

公开(公告)日：1997-02-20

申请号：DE68927649

申请日：1989-08-09

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAN HIROAKI ,  SAKAMOTO NAOYA ,  HATA EIICHIROU ,  ISHITOKU TAKESHI ,  KIHARA NORIAKI

IPC: C07D519/04 ,  A61K31/395

Abstract: A method for producing 3',4'-anhydrovinblastine, which comprises reacting catharanthine with vindoline in the presence of Fe , removing or inactivating the Fe , and reacting the reaction product with a reducing agent. 3',4'-Anhydrovinblastine is useful as an antineoplastic drug.

公开(公告)号：AT147390T

公开(公告)日：1997-01-15

申请号：AT93108543

申请日：1989-08-09

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAN HIROAKI ,  SAKAMOTO NAOYA ,  HATA EIICHIROU ,  ISHITOKU TAKESHI ,  KIHARA NORIAKI

IPC: C07D519/04 ,  A61K31/395

Abstract: A method for producing 3',4'-anhydrovinblastine, which comprises reacting catharanthine with vindoline in the presence of Fe , removing or inactivating the Fe , and reacting the reaction product with a reducing agent. 3',4'-Anhydrovinblastine is useful as an antineoplastic drug.

公开(公告)号：AT92494T

公开(公告)日：1993-08-15

申请号：AT90302298

申请日：1990-03-05

Applicant: MITSUI PETROCHEMICAL IND

Inventor： SAKAMOTO NAOYA ,  CHOME WAKI-CHO ,  TAN HIROAKI ,  HATA EIICHIROU ,  KIHARA NORIAKI

IPC: C07D519/04

公开(公告)号：CA2011389A1

公开(公告)日：1990-09-04

申请号：CA2011389

申请日：1990-03-02

Applicant: MITSUI PETROCHEMICAL IND

Inventor： SAKAMOTO NAOYA ,  TAN HIROAKI ,  HATA EIICHIROU ,  KIHARA NORIAKI

IPC: C07D519/04

Abstract: The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

公开(公告)号：DE3781547D1

公开(公告)日：1992-10-08

申请号：DE3781547

申请日：1987-11-10

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TANIGUCHI KATSUO ,  TANAKA MICHIO ,  TAKAHATA KAZUNORI ,  SAKAMOTO NAOYA ,  TAKAI TOSHIHIRO ,  KURANO YOSHITO ,  ISHIBASHI MASAYASU

IPC: B01J29/18 ,  B01J29/00 ,  C07B61/00 ,  C07C1/00 ,  C07C2/66 ,  C07C2/86 ,  C07C15/00 ,  C07C15/02 ,  C07C15/14 ,  C07C15/16 ,  C07C15/24 ,  C07C37/08 ,  C07C39/15 ,  C07C43/263 ,  C07C67/00 ,  C07C67/08

Abstract: This improved process for producing alkyl group-substd. aromatic hydrocarbons comprises reacting an aromatic hydrocarbon (1) with an alkylating agent (2) in the presence of a mordenite zeolite catalyst treated with a fluorine-contg. cpd. The alkylating agent (2) is selected from olefins, aliphatic lower alcohols, and alkyl halides (pref. propylene). The pref. aromatic hydrocarbon (1) is biphenyl, dibiphenyl or naphthalene. The typical product is p,p'-diisopropylbiphenyl. The fluorine-contg. cpds. can be hydrogen fluoride, ammonium fluoride, CF3Cl, SF6. As an example, 4,4'-dihydroxybiphenyl is produced by the acid-decomposition of 4,4'-diisopropyl biphenyldihydroperoxide which is obtd. by oxidising 4,4'-diisopropylbiphenyl with oxygen molecules. The above 4,4'-diisopropylbiphenyl is reacted with acylising agent to obtain 4,4'-diacyloxybiphenyl.

公开(公告)号：DE68927649T2

公开(公告)日：1997-06-19

申请号：DE68927649

申请日：1989-08-09

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAN HIROAKI ,  SAKAMOTO NAOYA ,  HATA EIICHIROU ,  ISHITOKU TAKESHI ,  KIHARA NORIAKI

IPC: C07D519/04 ,  A61K31/395

Abstract: A method for producing 3',4'-anhydrovinblastine, which comprises reacting catharanthine with vindoline in the presence of Fe , removing or inactivating the Fe , and reacting the reaction product with a reducing agent. 3',4'-Anhydrovinblastine is useful as an antineoplastic drug.

公开(公告)号：CA1334588C

公开(公告)日：1995-02-28

申请号：CA607984

申请日：1989-08-10

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAN HIROAKI ,  SAKAMOTO NAOYA ,  HATA EIICHIROU ,  ISHITOKU TAKESHI ,  KIHARA NORIAKI

IPC: C07D519/04

Abstract: This invention concerns a method for the production of dimeric alkaloid, characterized by a procedure which comprises causing reaction of catharanthine with vindoline in the presence of Fe3+ and (1) removing or inactivating the Fe3+ and allowing the reaction product to react with a reducing agent or (2) allowing presence of oxygen and a dicarboxylic acid or a derivative thereof in the reaction system and allowing the reaction product to react with a hydride source. In accordance with this invention, such dimeric alkaloid as vinblastine, leurocidin, and 3',4'-anhydrovin-blastine which are useful as antineoplastic drugs can be produced in high yields.

公开(公告)号：DE69002489D1

公开(公告)日：1993-09-09

申请号：DE69002489

申请日：1990-03-05

Applicant: MITSUI PETROCHEMICAL IND

Inventor： SAKAMOTO NAOYA ,  TAN HIROAKI ,  HATA EIICHIROU ,  KIHARA NORIAKI

IPC: C07D519/04

Abstract: The present invention relates to a process for the preparation, from e.g. anhydrovinblastine, of binary indole alkaloids effective as an anti-cancer drug, such as vinblastine, leurosidine, etc., wherein a trivalent iron source and hydride source are added in the presence of oxygen, thereby increasing a yield of an object compound. The yield of an object compound is improved still more by further addition, to the reaction system, of an oxalic acid ion source, malonic acid ion source, inorganic anion source, amino acid, etc.

公开(公告)号：CA2066976A1

公开(公告)日：1992-10-26

申请号：CA2066976

申请日：1992-04-24

Applicant: MITSUI PETROCHEMICAL IND

Inventor： KONDO MASAHIRO ,  TANAKA MICHIO ,  SAKAMOTO NAOYA ,  OOYOSHI HAJIME

IPC: C07C227/42 ,  C07C227/02 ,  C07C227/10 ,  C07C229/52 ,  C07C227/18

Abstract: An improvement in a method of producing a keto acid having the general formula of (see formula I) wherein R1 and R2 independently represent an alkyl of 1-6 carbons or a cycloalkyl of 4-8 carbons, in an organic solvent, which comprises reacting a m-aminophenol having the general formula of (see formula II) wherein R1 and R2 are the same as above, with phthalic anhydride, the improvement comprising depositing the resultant keto acid in the solvent while effecting the reaction in a slurry.