公开(公告)号：KR840000496B1

公开(公告)日：1984-04-16

申请号：KR800003051

申请日：1980-07-31

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATO TOSHIO ,  YAMAGUCHI AKIHIRO ,  HIGUCHI CHOJIRO

IPC: C07C253/30 ,  C07C121/43

公开(公告)号：KR870000546B1

公开(公告)日：1987-03-18

申请号：KR830003553

申请日：1983-07-29

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MIDA RYUICHI ,  KATO TOSHIO ,  HIGUCHI JOJIRO ,  YAMAGUCHI AKIHIRO ,  OHOKA MASAHARAU

IPC: C07C323/58 ,  C07C67/00 ,  C07C313/00 ,  C30B29/54 ,  C07C149/247

公开(公告)号：KR870000368B1

公开(公告)日：1987-03-06

申请号：KR850002413

申请日：1985-04-10

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATO TOSHIO ,  HIKUCHI CHOJIRO ,  YAMAKUCHI AKIHIRO

IPC: C07C231/10 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C233/46 ,  C07C233/47 ,  C07C233/82 ,  C07C233/83 ,  C07C103/46

公开(公告)号：KR860001900B1

公开(公告)日：1986-10-24

申请号：KR820002154

申请日：1982-05-18

Applicant: MITSUI TOATSU CHEMICALS

Inventor： OOOKA MASAHARU ,  KATO TOSHIO ,  MITA RYUICHI ,  KAWASHIMA NOBUYUKI

IPC: C07C227/14 ,  C07C101/10

Abstract: Beta-chloroalanine was prepd. from aziridine-2-carbonate and HCl. Thus, 236 g of 32% aq. soln. of Na aziridine-2-carbonate was added to 168 g of 35% HCl, reacted 1 h at 40-45≦̸C, and chilled to -16≦̸C for 2h to yield beta-chloroalanine, which was filtered and washed with iso- Pro. The filtrate was reacted with 388 g of 10% NaOH soln. at 45≦̸C for 4 h to yield 105 g of 32% Na aziridine-2carbonate, which was reacted with 85 g of 35% HCl to give betachloroalanine. The total yield was 64% based on the initial aziridine-2-carbonate-Na salt.

公开(公告)号：KR860001891B1

公开(公告)日：1986-10-24

申请号：KR820002428

申请日：1982-05-31

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  HIKUCHI CHOJIRO ,  OOOKA MASAHARU ,  KATO TOSHIO

IPC: C07C319/02 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C323/58 ,  C07C325/00 ,  C07C329/00 ,  C07C149/247 ,  C07C148/00

Abstract: DL-cystein is prepd. industrially by reacting beta halo alanine with trithiocarbfonate and decomposing the resultant trithiocarbonate acid mono(aminocarboxylethyl)ester with acid. DL-cystein is useful as a medical supply and cosmetic. The trithio carbonate is pref. an alkali metal, alkali earth metal or ammonium salt, the amount thereof per 1mol., beta halo-alanine is 1-10 mol. pref. 1-5 mol. and these materials are reacted at from -20≦̸C to 100≦̸C, pref, 0 - 80≦̸C for 1-30 hrs., pref. 2-20 hrs.. Acidolysis can be effected e.g. by directly adding sulphuric aicd to the reaction system or blowing in hydrogen chloride gas and heating at 0-80≦̸C for 0.5-50 hrs.

公开(公告)号：KR840000418B1

公开(公告)日：1984-04-02

申请号：KR800004809

申请日：1980-12-17

Applicant: MITSUI TOATSU CHEMICALS

Inventor： NAGAI SHOSUKE ,  HIGUCHI CHOJIRO ,  MITA RYUICHI ,  KATO TOSHIO ,  KAWASHIMA NOBUYUKI ,  YAMAGUCHI AKIHIRO

IPC: C07C253/14 ,  C07C120/00 ,  C07C121/16

公开(公告)号：KR840000280B1

公开(公告)日：1984-03-13

申请号：KR800004690

申请日：1980-12-10

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATO TOSHIO ,  YAMAGUCHI AKIHIRO ,  HIGUCHI CHOJIRO ,  KAWASHIMA NOBUYUKI

IPC: C07C227/14 ,  C07C101/30 ,  C07C99/00

公开(公告)号：MX7073E

公开(公告)日：1987-05-06

申请号：MX10181780

申请日：1980-12-09

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA AYUICHI ,  HIGUCHI CHOJIRO ,  KATO TOSHIO ,  KAWASHIMA NOBUYUKI ,  YAMAGUCHI AKIHIRO ,  NAGAI SHOSUKE ,  TAKANO TAKAO

IPC: A61K31/195 ,  C07K1/04

公开(公告)号：MX6502E

公开(公告)日：1985-06-21

申请号：MX10155580

申请日：1980-12-11

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  HIGUCHI CHOJIRO ,  KATO TOSHIO ,  KABASHIMA NOBUYUKI ,  YAMAGUCHI AKIHIRO ,  NAGAI SHOSUKE ,  TAKANO TAKAO

IPC: C07D203/18

公开(公告)号：DE3070355D1

公开(公告)日：1985-04-25

申请号：DE3070355

申请日：1980-12-17

Applicant: MITSUI TOATSU CHEMICALS

Inventor： KAWASHIMA NOBUYUKI ,  HIGUCHI CHOJIRO ,  KATO TOSHIO ,  MITA RYUICHI ,  YAMAGUCHI AKIHIRO ,  NAGAI SHOSUKE ,  TAKANO TAKAO

IPC: C07D203/02 ,  C07D203/08