公开(公告)号：KR840000496B1

公开(公告)日：1984-04-16

申请号：KR800003051

申请日：1980-07-31

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATO TOSHIO ,  YAMAGUCHI AKIHIRO ,  HIGUCHI CHOJIRO

IPC: C07C253/30 ,  C07C121/43

公开(公告)号：KR870000368B1

公开(公告)日：1987-03-06

申请号：KR850002413

申请日：1985-04-10

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATO TOSHIO ,  HIKUCHI CHOJIRO ,  YAMAKUCHI AKIHIRO

IPC: C07C231/10 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C233/46 ,  C07C233/47 ,  C07C233/82 ,  C07C233/83 ,  C07C103/46

公开(公告)号：KR860001900B1

公开(公告)日：1986-10-24

申请号：KR820002154

申请日：1982-05-18

Applicant: MITSUI TOATSU CHEMICALS

Inventor： OOOKA MASAHARU ,  KATO TOSHIO ,  MITA RYUICHI ,  KAWASHIMA NOBUYUKI

IPC: C07C227/14 ,  C07C101/10

Abstract: Beta-chloroalanine was prepd. from aziridine-2-carbonate and HCl. Thus, 236 g of 32% aq. soln. of Na aziridine-2-carbonate was added to 168 g of 35% HCl, reacted 1 h at 40-45≦̸C, and chilled to -16≦̸C for 2h to yield beta-chloroalanine, which was filtered and washed with iso- Pro. The filtrate was reacted with 388 g of 10% NaOH soln. at 45≦̸C for 4 h to yield 105 g of 32% Na aziridine-2carbonate, which was reacted with 85 g of 35% HCl to give betachloroalanine. The total yield was 64% based on the initial aziridine-2-carbonate-Na salt.

公开(公告)号：KR860001885B1

公开(公告)日：1986-10-24

申请号：KR820002182

申请日：1982-05-19

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  HIKUCHI CHOJIRO ,  GAWASHIMA NOBUYUKI ,  KAWASHIMA NOBUHIRO

IPC: C07C227/14 ,  C07C101/30

Abstract: Compds. of the formula (I) [R1,R2=H, CH3, (un)substd. Ph. or pyridyl! were prepd. Thus, 160 ml of aq. soln. of 12.9 g 3-methylaziridine-2- carbonylethylester were subjected over cationexchange resin, Lewatit S-100(H-type) (Bayer Co.), washed with 60 ml distd. H2O and absorbed on the resin. The resin was heated 7 h at 80-85 ≦̸C in 100 ml of flask, packed on column, and eluted was concd. and dried to yield 11.4 g threonine(Yield 88.6%, Purity 92.5%).

公开(公告)号：KR860001891B1

公开(公告)日：1986-10-24

申请号：KR820002428

申请日：1982-05-31

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  HIKUCHI CHOJIRO ,  OOOKA MASAHARU ,  KATO TOSHIO

IPC: C07C319/02 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C323/58 ,  C07C325/00 ,  C07C329/00 ,  C07C149/247 ,  C07C148/00

Abstract: DL-cystein is prepd. industrially by reacting beta halo alanine with trithiocarbfonate and decomposing the resultant trithiocarbonate acid mono(aminocarboxylethyl)ester with acid. DL-cystein is useful as a medical supply and cosmetic. The trithio carbonate is pref. an alkali metal, alkali earth metal or ammonium salt, the amount thereof per 1mol., beta halo-alanine is 1-10 mol. pref. 1-5 mol. and these materials are reacted at from -20≦̸C to 100≦̸C, pref, 0 - 80≦̸C for 1-30 hrs., pref. 2-20 hrs.. Acidolysis can be effected e.g. by directly adding sulphuric aicd to the reaction system or blowing in hydrogen chloride gas and heating at 0-80≦̸C for 0.5-50 hrs.

公开(公告)号：KR840000418B1

公开(公告)日：1984-04-02

申请号：KR800004809

申请日：1980-12-17

Applicant: MITSUI TOATSU CHEMICALS

Inventor： NAGAI SHOSUKE ,  HIGUCHI CHOJIRO ,  MITA RYUICHI ,  KATO TOSHIO ,  KAWASHIMA NOBUYUKI ,  YAMAGUCHI AKIHIRO

IPC: C07C253/14 ,  C07C120/00 ,  C07C121/16

公开(公告)号：KR840000280B1

公开(公告)日：1984-03-13

申请号：KR800004690

申请日：1980-12-10

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATO TOSHIO ,  YAMAGUCHI AKIHIRO ,  HIGUCHI CHOJIRO ,  KAWASHIMA NOBUYUKI

IPC: C07C227/14 ,  C07C101/30 ,  C07C99/00

公开(公告)号：DE69205076D1

公开(公告)日：1995-11-02

申请号：DE69205076

申请日：1992-06-26

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  SHIMUTA NOBUO ,  UEDA MAMORU ,  NAGATAKE YOSIRO ,  TAJIRI TOYOHIRO

IPC: C07C17/42 ,  C07C25/08

Abstract: A triethylene glycol derivative is added to p-dichlorobenzene so as to prevent consolidation and improve flowability of p-dichlorobenzene.

公开(公告)号：DE3888781T2

公开(公告)日：1994-10-27

申请号：DE3888781

申请日：1988-10-11

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  OURA TAKESHI ,  KATOH TOSHIO ,  HIGUCHI CHOJIRO ,  YAMAGUCHI AKIHIRO ,  AJIOKA MASANOBU

IPC: C07K5/072 ,  C07K5/075 ,  C07K1/14 ,  C07K5/06

Abstract: A method for preparing alpha -L-aspartyl-L-phenylalanine methyl ester having improved solubilization by the isolation thereof from an aqueous medium containing at least one additive selected from the group consisting of sodium alginate, sodium salt of carboxymethylcellulose, sodium starch glycolate and sodium polyacrylate.

公开(公告)号：CA1298682C

公开(公告)日：1992-04-07

申请号：CA553487

申请日：1987-12-03

Applicant: MITSUI TOATSU CHEMICALS

Inventor： MITA RYUICHI ,  KATOH TOSHIO ,  HIGUCHI CHOJIRO ,  OURA TAKESHI ,  YAMAGUCHI AKIHIRO

IPC: A23L27/30 ,  C07K1/02 ,  C07K5/06 ,  C07K5/075

Abstract: a-L-aspartyl-L-phenylalanine methyl ester or the hydrohalide thereof is prepared by esterifying a-L-aspartyl-L-phenylalanine or a-L-aspartyl-L-phenylalanine which has been formed in situ by treating an N-protected-a-L-aspartyl- L-phenylalanine in an aqueous solution of sulfuric acid or a methanol-containing aqueous solution of sulfuric acid in the presence of an alkali metal halide or alkaline earth metal halide in a medium composed of sulfuric acid, water and methanol, thereby to allow the resulting a-L-aspartyl-L-phenyl-alanine methyl ester to precipitate as its corresponding hydrohalide, and then isolating the hydrohalide; and when the preparation of the methyl ester is desired, neutralizing the hydrohalide.