公开(公告)号：WO2002063274A1

公开(公告)日：2002-08-15

申请号：PCT/US2001/050226

申请日：2001-12-20

Applicant: MOLECULAR DYNAMICS, INC. ,  ARMSTRONG, Thomas, M. ,  LYTLE, John ,  BASHKIN, John, S.

Inventor： ARMSTRONG, Thomas, M. ,  LYTLE, John ,  BASHKIN, John, S.

IPC: G01N1/10

CPC classification number: G01N27/44721

Abstract: A tube or chamber (30) comprising an optically tubular body (32) having an exterior surface (34) and an interior surface (36). The body wall (32) includes a first portion, through which incident radiation passes, having a non-uniform thickness about the sample passageway.

Abstract translation: 包括具有外表面（34）和内表面（36）的光学管状体（32）的管或室（30）。 主体壁（32）包括入射辐射通过的第一部分，在样品通道周围具有不均匀的厚度。

公开(公告)号：EP1092146A1

公开(公告)日：2001-04-18

申请号：EP99914994.1

申请日：1999-03-23

Applicant: MOLECULAR DYNAMICS

Inventor： ROACH, David, J. ,  LODER, Robert, T., Jr. ,  ARMSTRONG, Thomas, M. ,  HARRIS, Dennis, W. ,  JOVANOVICH, Stevan, B. ,  JOHNSTON, Richard, F.

IPC: G01N27/26 ,  G01N35/10

CPC classification number: G01N27/44704 ,  B01L3/5027 ,  B01L99/00 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N35/0099 ,  G01N35/1074 ,  G01N2035/00059 ,  G01N2035/00158 ,  G01N2035/0437 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A substrate (15) with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate (15), and prepare for a new run. The other objects include a gripper (11) for engaging and moving the substrate, an electrode array of fine wires (78) suitable for fitting into the microchannels for electromigration, and a scanning detector for reading migration results. A sequence of automatic operations is established so that one substrate after another may be moved into position, loaded with sample, stimulated for molecular migration, read with a beam, and then removed and replaced with a fresh substrate.

Abstract translation: 具有多个微通道的基板（15）与其他可移动物体可移动地展开，这些可移动物体将样品装载到微通道中，刺激分子迁移，读取迁移的结果，移除和替换基板（15），并准备新的 跑。 其他目的包括用于接合和移动基板的夹持器（11），适合于装配到用于电迁移的微通道中的细线（78）的电极阵列以及用于读取迁移结果的扫描检测器。 建立一系列的自动操作，使一个接一个的基板可以移动到位，装载样品，受到分子迁移的刺激，用光束读取，然后取出并用新鲜的基材代替。