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    HIGH-SPEED LIQUID DEPOSITION DEVICE FOR BIOLOGICAL MOLECULE ARRAY FORMATION
    1.
    发明申请
    HIGH-SPEED LIQUID DEPOSITION DEVICE FOR BIOLOGICAL MOLECULE ARRAY FORMATION 审中-公开
    用于生物分子阵列形成的高速液体沉积装置

    公开(公告)号：WO1997046319A1

    公开(公告)日：1997-12-11

    申请号：PCT/US1997009649

    申请日：1997-06-03

    Applicant: MOLECULAR DYNAMICS, INC.

    Inventor： MOLECULAR DYNAMICS, INC. ,  ROACH, David, J. ,  JOHNSTON, Richard, F.

    IPC: B01L03/02

    CPC classification number: B01L3/0262 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00639 ,  B01J2219/00659 ,  B01J2219/0072 ,  B01L3/0248 ,  B01L3/0255 ,  B01L2300/0838 ,  C40B60/14 ,  G01N2035/1037 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: A microspot deposition system (12) featuring a hollow cylindrical wall (26) extending from a closed end (28), terminating in an open end (30) and including a longitudinal gap (34) extending from the open end (30) toward the closed end (28) to allow the rapid exhaustion of the atmosphere and efficient cleaning within the cylindrical wall (26). The cylindrical wall (26) defines a lumen (32) with both the lumen (32) and the gap (34) adapted to facilitate capillary action of liquid in fluid communication therewith to form a meniscus (46) proximate to the open end (30). To facilitate deposition of liquid contained within the lumen (32), the gap (34) may be tapered so that it is narrowest proximate to the open end (30). The narrowed portion of the gap (34) results in a meniscus (46) having a reduced area to ensure preferential fluid flow toward the open end (30), which facilitates deposition via capillary action between the liquid in the lumen (32) and a working surface (52).

    Abstract translation: 一种微孔沉积系统（12），其具有从封闭端（28）延伸的中空圆柱形壁（26），终止于开口端（30），并且包括从开口端（30）延伸的纵向间隙（34） 闭合端（28）以允许气氛的快速耗尽并且在圆柱形壁（26）内进行有效的清洁。 圆柱形壁（26）限定内腔（32），内腔（32）和间隙（34）都适于促进与其流体连通的液体的毛细作用，以形成靠近开口端（30）的弯月面（46） ）。 为了便于包含在内腔（32）内的液体的沉积，间隙（34）可以是锥形的，使得其在开口端（30）附近最窄。 间隙（34）的变窄的部分导致弯液面（46）具有减小的面积，以确保朝向开口端（30）的优先流体流动，这有利于通过管腔（32）中的液体和 工作面（52）。

    ROBOTIC MICROCHANNEL BIOANALYTICAL INSTRUMENT
    4.
    发明公开
    ROBOTIC MICROCHANNEL BIOANALYTICAL INSTRUMENT 审中-公开
    机器人微通道生物分析仪器

    公开(公告)号：EP1092146A1

    公开(公告)日：2001-04-18

    申请号：EP99914994.1

    申请日：1999-03-23

    Applicant: MOLECULAR DYNAMICS

    Inventor： ROACH, David, J. ,  LODER, Robert, T., Jr. ,  ARMSTRONG, Thomas, M. ,  HARRIS, Dennis, W. ,  JOVANOVICH, Stevan, B. ,  JOHNSTON, Richard, F.

    IPC: G01N27/26 ,  G01N35/10

    CPC classification number: G01N27/44704 ,  B01L3/5027 ,  B01L99/00 ,  G01N27/44743 ,  G01N27/44782 ,  G01N27/44791 ,  G01N35/0099 ,  G01N35/1074 ,  G01N2035/00059 ,  G01N2035/00158 ,  G01N2035/0437 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: A substrate (15) with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate (15), and prepare for a new run. The other objects include a gripper (11) for engaging and moving the substrate, an electrode array of fine wires (78) suitable for fitting into the microchannels for electromigration, and a scanning detector for reading migration results. A sequence of automatic operations is established so that one substrate after another may be moved into position, loaded with sample, stimulated for molecular migration, read with a beam, and then removed and replaced with a fresh substrate.

    Abstract translation: 具有多个微通道的基板（15）与其他可移动物体可移动地展开，这些可移动物体将样品装载到微通道中，刺激分子迁移，读取迁移的结果，移除和替换基板（15），并准备新的 跑。 其他目的包括用于接合和移动基板的夹持器（11），适合于装配到用于电迁移的微通道中的细线（78）的电极阵列以及用于读取迁移结果的扫描检测器。 建立一系列的自动操作，使一个接一个的基板可以移动到位，装载样品，受到分子迁移的刺激，用光束读取，然后取出并用新鲜的基材代替。

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