公开(公告)号：US20200246487A1

公开(公告)日：2020-08-06

申请号：US16622136

申请日：2018-06-08

Applicant: MONASH UNIVERSITY

Inventor： Colin William POUTON ,  Kha Tu Joan HO ,  Paul James WHITE ,  Catherine Thoa BUI ,  Nabila AKHTAR ,  Hareth Ali AL-WASSITI

IPC: A61K48/00 ,  A61K9/14 ,  C12N15/88 ,  A61K9/00

Abstract: Non-viral nucleic acid delivery agents and methods for the delivery or transfer of nucleic acid molecules to target cells are disclosed. The agents comprise a complex of a nucleic acid cargo for delivery, one or more lipopeptide compound, and one or more polymeric charge-neutralising agent, and the complex is in the form of a particle with substantially neutral or negative surface charge. The agents and methods may be useful in a variety of applications such as therapies (including gene therapies and nucleic acid vaccinations) for diseases and medical disorders.