公开(公告)号：US20210299447A1

公开(公告)日：2021-09-30

申请号：US17346971

申请日：2021-06-14

Applicant: MONASH UNIVERSITY

Inventor： Paul B FITZGERALD ,  Caley M. Sullivan ,  Richard H. THOMSON

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/369 ,  A61B5/375

Abstract: Closed-loop transcranial stimulation and monitoring is disclosed that includes generating a stimulation signal having a set of first oscillation parameters; applying the stimulation signal transcranially to a patient; monitoring the stimulation signal as applied to the patient; receiving a brain activity signal from the patient; generating a feedback signal based on the monitored stimulation signal as applied to the patient; and generating a modified activity signal by subtracting the feedback signal from the brain activity signal; determining one or more second oscillation parameters of the modified activity signal; and adjusting the set of first oscillation parameters of the stimulation signal based on the one or more second oscillation parameters of the modified activity signal. Closed-loop transcranial stimulation and monitoring is also disclosed in which the patient is engaged in a cognitive task.

公开(公告)号：US20220118247A1

公开(公告)日：2022-04-21

申请号：US17288125

申请日：2019-10-25

Applicant: MONASH UNIVERSITY

Inventor： Richard H. THOMSON ,  Paul B. FITZGERALD ,  Caley SULLIVAN ,  Mark HARRISON

IPC: A61N1/08 ,  A61N1/20 ,  A61N1/05

Abstract: An apparatus for performing bioelectric stimulation, the apparatus comprising: a stimulation unit; a measurement unit comprising an amplifier; first and second stimulation electrodes operable to apply electrical signals to tissue of a patient; first and second measurement electrodes operable to receive first and second measurement signals from the tissue of the patient; wherein the stimulation unit is configured to deliver a first stimulation signal to the first stimulation electrode and a second stimulation signal to the second stimulation electrode; wherein the first signal and the second signal are mirrored about a biasing voltage, the biasing voltage set in dependence of the dynamic range of the amplifier.

公开(公告)号：US20190134395A1

公开(公告)日：2019-05-09

申请号：US16092989

申请日：2017-04-10

Applicant: MONASH UNIVERSITY

Inventor： Paul B FITZGERALD ,  Caley LIVAN ,  Richard H. THOMSON

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/0482

Abstract: Closed-loop transcranial stimulation and monitoring is disclosed that includes generating a stimulation signal having a set of first oscillation parameters; applying the stimulation signal transcranially to a patient; monitoring the stimulation signal as applied to the patient; receiving a brain activity signal from the patient; generating a feedback signal based on the monitored stimulation signal as applied to the patient; and generating a modified activity signal by subtracting the feedback signal from the brain activity signal; determining one or more second oscillation parameters of the modified activity signal; and adjusting the set of first oscillation parameters of the stimulation signal based on the one or more second oscillation parameters of the modified activity signal. Closed-loop transcranial stimulation and monitoring is also disclosed in which the patient is engaged in a cognitive task.